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Dibenzocyclooctadiene lignan, preparation method and use thereof

A technology of biphenyl cyclooctene and lignans, which is applied in the fields of active ingredients of heterocyclic compounds, antipyretics, organic chemistry, etc., can solve the problems of unreported medicinal research of chemical composition, and achieve good anti-inflammatory effect , easy to operate, simple preparation method

Inactive Publication Date: 2009-10-14
SUZHOU UNIV
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Problems solved by technology

However, black tiger has always been used as a national medicine, and the medicinal research on the chemical composition of its root and stem extracts has not been reported.

Method used

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  • Dibenzocyclooctadiene lignan, preparation method and use thereof
  • Dibenzocyclooctadiene lignan, preparation method and use thereof
  • Dibenzocyclooctadiene lignan, preparation method and use thereof

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Embodiment 1

[0017] A preparation method of biphenyl cyclooctene lignans, comprising the steps of: taking the roots and stems of the black tiger Kadsuracoccinea (Lem.) A C. as raw materials, extracting 3 Once, each time for 24 hours, the extracts were combined and concentrated to obtain the extract, which was then extracted with cyclohexane, chloroform, ethyl acetate and n-butanol in sequence, and the chloroform layer part was subjected to column chromatography with a silica gel column to obtain the obtained Biphenyl cyclooctene lignans. The solvent system of the column chromatography is a mixed solvent of chloroform-methanol, and the ratio of chloroform:methanol is 100:0-0:100 by volume for gradient elution.

[0018] The above-mentioned biphenyl cyclooctene lignans have a structural formula of:

[0019]

[0020] where: R 1 for

[0021] Application of the above-mentioned biphenyl cyclooctene lignans in the preparation of anti-inflammatory drugs.

[0022] The present invention has ...

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Abstract

The invention discloses a dibenzocyclooctadiene lignan and a preparation method thereof. The preparation method comprises the following steps of taking roots and stems of Kadsura coccinea (Lem.) A C. as raw materials, smashing the raw materials, then using acetone water solution with the volume concentration of 50-95 percent for extracting for 1-10 times with each time lasting 5-50 hours, mergingextract liquid, concentrating, obtaining a liquid extract, then sequentially using cyclohexane, chloroform, ethyl acetate and n-butanol for extracting, and carrying out column chromatography on the part of a chloroform layer by using a silica gel column, thereby obtaining the dibenzocyclooctadiene lignan. The lignan has good anti-inflammation effect and good application prospect in the preprationof anti-inflammation drugs, thereby having significant and positive significance.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a biphenyl cyclooctene lignan, a preparation method and an application thereof. Background technique [0002] Black tiger Kadsura coccinea (Lem.) A C., also known as Lengfantuan, Guoshanlongteng, etc., belongs to Schisandraceae. Its root bark is dry, slightly rough on the outside, brittle, brown in color, reddish brown on the inside, and fragrant. The taste is slightly bitter and astringent, mainly distributed in Hubei, Guangdong, Guangxi, Sichuan, Yunnan, Guizhou and other places; it is mainly used to treat rheumatic bone pain, sprains, women's dysmenorrhea, chronic gastritis and other diseases. The root extract has certain sedative and anti-inflammatory effects . However, black tiger has always been used as a national medicine, and the medicinal research on the chemical composition of its root and stem extracts has not been reported. Contents...

Claims

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Application Information

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IPC IPC(8): C07D317/70A61K31/36A61P29/00
Inventor 李贺然季改
Owner SUZHOU UNIV
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