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Application of steroid compounds or plant extracts containing same in preventing and treating prostatoplasia diseases

A technology of compounds and steroids, applied in the field of application of steroids or plant extracts containing them in the prevention and treatment of benign prostatic hyperplasia, can solve the problems of inhibiting aromatase activity that have not been reported, and achieve the prevention and treatment of benign prostatic hyperplasia Disease, inhibition of aromatase activity, suitable for long-term use

Active Publication Date: 2011-09-28
SHANGHAI INST OF PHARMA IND CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report in the literature about the inhibition of aromatase activity by steroids

Method used

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  • Application of steroid compounds or plant extracts containing same in preventing and treating prostatoplasia diseases
  • Application of steroid compounds or plant extracts containing same in preventing and treating prostatoplasia diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] 1) Supercritical extraction: Take 1000g of broken rapeseed pollen, extract with supercritical carbon dioxide, collect supercritical extracted parts, and obtain effective parts. Ethanol, its consumption is 8% of the broken pollen weight.

[0018] 2) Column chromatography: perform silica gel column chromatography on the above-mentioned effective parts, the silica gel is 300 mesh, and the dosage is 3 times the mass of the effective parts; gradient elution is carried out with eluent petroleum ether-ethyl acetate, and the gradient is volume ratio : 100: 0, 100: 1, 100: 5, 100: 10, the amount of each gradient eluent is 3 times the column volume; it is detected by normal phase silica gel thin layer chromatography, and when the collecting solvent is chloroform, Rf = 0.3-0.6 eluate, evaporate the solvent to obtain a crude product.

[0019] 3) Purification: The crude product obtained in the above steps is subjected to silica gel column chromatography, the silica gel is 300 mesh,...

Embodiment 2

[0021] 1) Extraction: Take 1000 g of corn pollen after breaking the wall, pulverize it, heat and reflux 3 times with 95% (volume percentage) ethanol at a ratio of 10 ml / g corn pollen, filter, combine the filtrates, recover the solvent under reduced pressure, and obtain a liquid extract 80g, the relative density of the liquid extract is 1.5, suspended in 1000mL water, extracted with petroleum ether, chloroform and ethyl acetate respectively, each solvent is extracted 3 times, and the amount of each extraction solvent is equal to the volume of the aqueous solution, and the extracted ethyl acetate is collected. part, the solvent is recovered under reduced pressure to obtain the effective part.

[0022] 2) Column chromatography: perform silica gel column chromatography on the above-mentioned effective parts, the silica gel is 400 mesh, and the dosage is 20 times the mass of the crude product; gradient elution is carried out with petroleum ether-ethyl acetate, the gradient is volume...

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PUM

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Abstract

The invention discloses an application of steroid compounds or plant extracts containing same in preventing and treating prostatoplasia diseases, especially the application of the steroid compounds including 24-methylenecholesterol, or cycloeucalenol or pollinastanol or plant extracts containing the steroid compounds in preparing preparations to inhibit the activity of aromatizing enzyme and in preparing pharmaceutical compositions to prevent or treat prostatoplasia diseases. The application opens up a new application field for the compound and also provides a new way for preventing and treating diseases in the field.

Description

technical field [0001] The present invention relates to a new application of a class of compounds and plant extracts containing them, in particular to 24-methylene cholesterol, cycloeucalyptol or pollen sterol, or plant extracts containing them in the preparation of aromatase inhibiting Application in active preparations, pharmaceutical compositions for preventing or treating prostatic hyperplasia. Background technique [0002] Benign prostatic hyperplasia (BPH) is a common physiological lesion in elderly men. When the lesion causes a series of symptoms such as urinary obstruction, it is called benign prostatic hyperplasia. Autopsy reports of 1075 cases abroad showed that: at the age of 25 to 30, 10% of men could see early benign prostatic hyperplasia lesions under the microscope; as the age increases, the incidence of benign prostatic hyperplasia diagnosed by histology also increases accordingly; By the age of 51 to 60, the incidence rate increases to 75%; by the age of 85...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/575A61K36/31A61K36/899A61P13/08
Inventor 杨义芳李永辉李坤杨念云
Owner SHANGHAI INST OF PHARMA IND CO LTD
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