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A magnetic sensor device for and a method of sensing magnetic particles

A magnetic sensor and magnetic particle technology, applied in the size/direction of the magnetic field, the measurement of magnetic bead-labeled molecules, and the measurement of magnetic variables, etc., can solve problems such as the problem of sufficient accuracy of measurement results

Inactive Publication Date: 2009-12-23
KONINKLIJKE PHILIPS ELECTRONICS NV
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  • Abstract
  • Description
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Problems solved by technology

[0010] However, sufficient accuracy of the measurement results may still be a problem in undesired situations

Method used

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  • A magnetic sensor device for and a method of sensing magnetic particles
  • A magnetic sensor device for and a method of sensing magnetic particles
  • A magnetic sensor device for and a method of sensing magnetic particles

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Embodiment Construction

[0048] The illustrations in the figures are schematic. In different figures, similar or identical elements bear the same reference signs.

[0049] In a first embodiment, the device according to the invention is a biosensor and will refer to figure 1 be described. The biosensor detects magnetic particles in samples such as fluids, liquids, gases, viscoelastic media, gels or tissue samples. These magnetic particles can be of small size. Nanoparticles refer to particles having at least one dimension ranging between 0.1 nm and 1000 nm. These magnetic particles can acquire a magnetic moment due to an applied magnetic field.

[0050] The device may comprise a substrate 10 and circuitry, such as an integrated circuit.

[0051] The measuring surface of the device consists of figure 1 The dotted line in indicates. The circuit may comprise a magnetoresistive sensor 11 as sensor element and a first magnetic field generator in the form of a conductor 12 . In the following, the ter...

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Abstract

A magnetic sensor device (1000) for sensing magnetic particles (15), the magnetic sensor device (1000) comprising a first magnetic field generator unit (12) excitable for generating a first magnetic field, a sensing unit (11) adapted for sensing a signal indicative of the presence of the magnetic particles (15) in the first magnetic field, a second magnetic field generator unit (1001) adapted for generating a second magnetic field affecting the sensing unit (11), and a processing circuitry (1002) adapted for processing the signal to form a digitized signal and adapted for feeding back the processed signal to the second magnetic field generator unit (1001).

Description

technical field [0001] The present invention relates to a magnetic sensor device for sensing magnetic particles. [0002] The invention also relates to methods of sensing magnetic particles. Background technique [0003] A biosensor may be a device for detecting an analyte that combines a biological component with a biochemical or physical detector component. [0004] Magnetic biosensors can use the giant magnetoresistance effect (GMR) in order to detect magnetic or magnetic bead-labeled biomolecules. [0005] Hereinafter, biosensors that can use the giant magnetoresistance effect will be explained. [0006] WO2005 / 010542 discloses the detection or determination of the presence of magnetic particles using integrated or on-chip magnetic sensor elements. The device can be used for magnetic detection of bound biomolecules on microarrays or biochips. In particular, WO2005 / 010542 discloses a magnetic sensor device for determining the presence of at least one magnetic particle...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/543G01R33/06
CPCG01R33/093G01R33/12G01R33/07G01R33/1269B82Y25/00
Inventor J·A·T·M·范登霍姆伯格J·J·A·托尔H·杜里克
Owner KONINKLIJKE PHILIPS ELECTRONICS NV
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