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Preparation method and medical application of cynoglossum zeylanicum total phenolic acid

A technology of glabra grass and total phenolic acid, which can be applied in pharmaceutical formulations, medical preparations containing active ingredients, and drug combinations, etc., can solve the problems of total phenolic acids in glabra grass, which are not seen, and achieve a sufficient source of raw materials and low cost. Effect

Active Publication Date: 2010-01-06
SICHUAN GOODDOCTOR PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Among the existing drugs for the treatment of cardiovascular and cerebrovascular diseases, phenolic acids are widely used. Commonly used are salvianolic acid and hawthorn total phenolic acid.

Method used

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  • Preparation method and medical application of cynoglossum zeylanicum total phenolic acid
  • Preparation method and medical application of cynoglossum zeylanicum total phenolic acid
  • Preparation method and medical application of cynoglossum zeylanicum total phenolic acid

Examples

Experimental program
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Effect test

Embodiment 1

[0024] The preparation of embodiment 1 tablet

[0025] Weigh 5kg of glass herb medicinal material, cut into slices, soak and extract 3 times in water at 60°C, the amount of water used each time is 8 times the amount of medicinal material, each extraction is 1h, the extracts are combined, filtered, the filtrate is adjusted to PH=5, stirred evenly, Let it stand for 2 hours, centrifuge, and the supernatant passes through the pretreated HPD-100 macroporous adsorption resin column, washes with water until the reducing sugar reaction of the effluent is negative, and then washes with 60% ethanol (eluent) until the effluent is close to Colorless, collect the eluent, adjust the pH to neutral, concentrate under reduced pressure to form a fluid extract, dry under reduced pressure at 70°C to obtain 0.15kg of dry extract, which is the total phenolic acid of Glacis, crushed, and passed through a No. 6 sieve , add 0.19kg of soluble starch and 7g of sodium carboxymethyl starch, mix and granul...

Embodiment 2

[0027] The preparation of embodiment 2 capsules

[0028] Weigh 5kg of glass herbal medicine, cut into slices, immerse and extract 3 times in 70°C water, the amount of water used each time is 10 times the amount of medicinal materials, each extraction is 1.5h, combine the extracts, filter, adjust the filtrate to PH=4, and stir evenly , let it stand for 2 hours, centrifuge, the supernatant is passed through the pretreated D101 macroporous adsorption resin column, washed with water until the reducing sugar reaction of the effluent is negative, and then washed with 70% ethanol until the effluent is nearly colorless, collected and eluted liquid, adjust the pH to neutral, concentrate under reduced pressure until there is no alcohol smell, add ethanol until the alcohol content reaches 85%, store in cold storage for 12 hours, filter, concentrate the filtrate under reduced pressure to form a fluid extract, and dry it under reduced pressure at 70°C. Obtain 0.13kg of dry extract, which i...

Embodiment 3

[0030] The preparation of embodiment 3 granules

[0031] Weigh 5kg of glass herb medicinal material, slice it, extract 3 times with 60% ethanol under reflux, the dosage of 60% ethanol is 6 times the amount of medicinal material each time, extract for 2 hours each time, combine the extracts, filter, and recover the filtrate under reduced pressure until it has no alcohol smell , adjust the pH to 3, stir evenly, let stand for 3 hours, centrifuge, and the supernatant is passed through the pretreated AB-8 macroporous adsorption resin column, washed with water until the reducing sugar reaction of the effluent is negative, and then washed with 60% ethanol When the effluent is nearly colorless, collect the eluent, adjust the pH to neutral, concentrate under reduced pressure until there is no alcohol smell, add ethanol until the alcohol content reaches 75%, store in cold storage for 12 hours, filter, and concentrate the filtrate under reduced pressure to obtain a liquid The extract was...

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Abstract

The invention discloses a method for preparing cynoglossum zeylanicum total phenolic acid. The cynoglossum zeylanicum total phenolic acid is extracted from cynoglossum zeylanicum roots or the cynoglossum zeylanicum, and through a component analysis, the cynoglossum zeylanicum total phenolic acid contains phenolic acid compounds such as salvanolic acid A, salvanolic acid B, and the like. Proved by a drug effect research, the cynoglossum zeylanicum total phenolic acid has better effect on treating prostate diseases and heart cerebrovascular diseases so as to provide a new medicine selection for clinically treating the prostate diseases and the heart cerebrovascular diseases.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine extract and its medical application, in particular to a preparation method of glaucola total phenolic acid and its medical application. Background technique [0002] Glass grass is a plant of the genus Cynoglossum of the family Boraginaceae. There are about 60 species in the world, which are widely distributed in the world. There are 10 species and 2 varieties in my country, which are distributed in all provinces and regions of the country. The southwest region is its distribution center. It is mainly produced in Yunnan, Sichuan, Tibet. Most of the plants in this genus have medicinal effects. The roots and whole herbs are used as medicine. According to the records of "Chinese Materia Medica", it is cold in nature and slightly bitter. In clinical use, it is taken internally to treat acute nephritis, periodontitis, hepatitis, irregular menstruation, abnormal leucorrhea, edema...

Claims

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Application Information

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IPC IPC(8): A61K36/30A61P9/00A61P13/08
Inventor 吴桃清王存林耿福能刘彬张杨李华菊
Owner SICHUAN GOODDOCTOR PHARMA GRP
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