Joint synergy of ferulic acid and matrine alkaloid and medical application thereof

A technology of synergy and matrine, applied in the direction of drug combination, medical preparations containing active ingredients, pharmaceutical formulas, etc.

Inactive Publication Date: 2010-03-17
QINGDAO QIYUAN BIO TECH CO LTD
View PDF0 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This new discovery has no simi

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Joint synergy of ferulic acid and matrine alkaloid and medical application thereof
  • Joint synergy of ferulic acid and matrine alkaloid and medical application thereof
  • Joint synergy of ferulic acid and matrine alkaloid and medical application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Example 1 Observation of curative effect of ferulic acid matrine gel on ankle sprain

[0011] The composition of ferulic acid and matrine is made into a gel according to the requirements of pharmacy, and each 20g contains 60mg of ferulic acid and 140mg of matrine. 30 pairs of acute ankle sprains were divided into experimental treatment group and control group. There were 30 cases in each group, and the test group used the method of smearing Voltaren externally, 4-6 times a day, and the course of treatment was 3 days. The control group adopted the method of external application of ferulic acid matrine gel, 4-6 times a day, and the course of treatment was 3 days.

[0012] Efficacy observation: the swelling and pain basically disappeared, it was markedly effective; the mild swelling and pain basically disappeared, it was effective; the swelling and pain did not get better, it was ineffective.

[0013] Results: In the test group, 12 cases were markedly effective, 16 cases...

Embodiment 2

[0015] Example 2. Observation of analgesic effect of ferulic acid matrine composition

[0016] Matrine ferulic acid is mixed in a certain proportion, heated and sterilized at 121°C, and then made into an injection.

[0017] Select healthy mice and randomly divide them into 6 groups, matrine 50mg / kg, matrine 10mg / kg, matrine 10mg / kg+ ferulic acid 2.5mg / kg, matrine 10+ ferulic acid 5mg / kg, matrine 10mg / kg+ ferulic acid 10mg / kg, and blank control group. 10 in each group. Each group was injected intraperitoneally for 3 consecutive days. 30 minutes after the last administration, 0.6% acetic acid 10ml / kg was injected intraperitoneally, and the number of writhing reactions in mice within 15 minutes was recorded. Calculate the percentage of drug analgesia.

[0018] Percentage of drug analgesia (%) = (number of times of writhing in the control group and number of times of writhing in the treatment group) / number of times of writhing in the control group × 100%

[0019] Results: Mat...

Embodiment 3

[0022] Example 3: Observation of anti-inflammatory effect of ferulic acid matrine composition.

[0023] Ferulic acid and matrine are mixed in a molar ratio of 1:1 and then heated to make an oral preparation.

[0024] Select mice and randomly divide them into 5 groups, matrine 25mg / kg, matrine 50mg / kg, matrine 25mg / kg + ferulic acid 10mg / kg, matrine 12.5mg / kg + ferulic acid 5mg / kg and blank control group, 10 in each group. After weighing and marking, the right ear of the mouse was touched with a xylene cotton ball for 5 minutes, and the left ear was used as a control. After 10 minutes of inflammation, a drug concentration of 1% of the test drug was applied to the inflamed ear shells respectively. , the blank control group was given normal saline, and the mice were killed by dislocation after 30 minutes, and the same area of ​​the left (self-control) and right ears (treated with xylene) were taken from the same part of the ear with a 6mm diameter puncher and weighed to calcula...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to joint synergy of ferulic acid and matrine alkaloid and a medical application thereof. A compound comprising ferulic acid and matrine alkaloid can obviously improve the pharmaceutical effect of the ferulic acid and/or the matrine alkaloid, can exist in a compound mode of sophora and angelica and/or hemlock parsley and asafetida extractive or can be a compound formed by monomeric compounds of the ferulic acid and/or the matrine alkaloid. The invention has anti-organ fibrosis action, hemorheology improvement, antiviral action, inflammatory action, cholinesterase inhibitory action, analgesic and antipruritic action, antithrombotic action, anti-platelet aggregation action, antibacterial action, antitumor action, oxidation-resistant action, hypolipemic action, immunity enhancement, sperm activity and motion stimulation, antihypertensive action, and the like which are obviously better than the single action of the ferulic acid or the matrine alkaloid.

Description

Technical field: [0001] Combined synergistic effect of ferulic acid and matrine alkaloids and their medical applications. Background technique [0002] The chemical name of ferulic acid is 4-hydroxy-3-methoxycinnamic acid. It is a kind of phenolic acid ubiquitous in the plant kingdom. It is one of the active ingredients of traditional Chinese medicines such as angelica, Chuanxiong, ferulicum, and widely exists in many kinds of plants. It can be obtained by extraction or synthesis. It has a wide range of pharmacological effects, such as anti-inflammatory, antibacterial, anti-oxidation, immune enhancement, anti-tumor, anti-cardiovascular disease, anti-fibrosis, anti-senile dementia, etc. have been reported. Sophora flavescens is one of the commonly used traditional Chinese medicine. It contains a variety of alkaloids, mainly matrine (matrine) and oxymatrine (oxyma-trine), followed by l-sophocarpine (l-sophocarpine), sophoridine (sophoridine), N-oxide Base (N-oxysophocarpine...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/4375A61K31/192A61K36/489A61K36/232A61P29/00A61P31/00A61P39/06A61P35/00A61P9/00A61P25/28
Inventor 宋健彭康康马维富
Owner QINGDAO QIYUAN BIO TECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap