Temperature responsive bio-adhesive in situ gel sustained-release preparation for vagina

A technology of bioadhesion and in-situ gel, which is applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, diseases, etc., to achieve less irritation of the ingredients, longer duration, and better safety Effect

Active Publication Date: 2012-10-24
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there is no report about the temperature-sensitive vaginal in situ gel based on the combination of poloxamer and carrageenan and its preparation method

Method used

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  • Temperature responsive bio-adhesive in situ gel sustained-release preparation for vagina
  • Temperature responsive bio-adhesive in situ gel sustained-release preparation for vagina
  • Temperature responsive bio-adhesive in situ gel sustained-release preparation for vagina

Examples

Experimental program
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Effect test

Embodiment 1

[0035] The following examples are used to illustrate the present invention, and should not be considered as limiting the present invention in any way. The preparation of embodiment 1 blank gel I

[0036] Weigh an appropriate amount of κ-carrageenan and dissolve it in pure water at 70-80° C., stir to fully dissolve it, and cool to room temperature to obtain a carrageenan stock solution (0.25%, w / w). Add 1 part of Poloxamer 407 to 4 parts (by weight) of 0.25% carrageenan stock solution, let it stand at 4°C until the solid components are dissolved, and stir evenly to obtain a uniform mixture, which is Blank Gel I. The gelation temperature of this embodiment is about 22-23°C. Wherein each component weight percent is as follows:

[0037] Reagent weight percentage (%)

[0038] κ-carrageenan 0.2

[0039] Poloxamer 407 20

Embodiment 2

[0040] The preparation of embodiment 2 blank gel II

[0041] The compounding method of carrageenan stock solution is the same as embodiment 1. Add 1 part of Poloxamer407 and an appropriate amount of Carbopol934P-NF to 4 parts (weight ratio) of 0.25% carrageenan stock solution, let it stand at 4°C until the solid components are dissolved, and stir evenly to obtain a uniform mixture, which is Blank Gel II. The gelation temperature of this embodiment is about 23-24°C. Wherein each component weight percent is as follows:

[0042] Reagent weight percentage (%)

[0043] κ-carrageenan 0.2

[0044]Poloxamer 407 20

[0045] Carbopol934P-NF0.2

Embodiment 3

[0046] The preparation of embodiment 3 blank gel III

[0047] The experimental procedure was the same as in Example 1. However, while adding Poloxamer407 and Carbopol934 to the carrageenan stock solution, an appropriate amount of methyl p-hydroxybenzoate was added. The resulting gel is Blank Gel III. The gelation temperature of this embodiment is about 22-23°C. Wherein each component weight percent is as follows:

[0048] Reagent weight percentage (%)

[0049] κ-carrageenan 0.2

[0050] Pol oxamer407 20

[0051] Carbopol934P-NF0.2

[0052] Methylparaben 0.1

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PUM

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Abstract

The invention belongs to the field of medicinal preparation, relating to a temperature responsive bio-adhesive in situ gel sustained-release preparation for vagina drug administration. The preparation is composed of poloxamer, carrageenan, at least one optional gel substrate material, such as polyacrylic acid and the like and at least one drug with effective treating amount. The preparation combines the reversed-phase gelation properties of poloxamer and the bio-adhesive property and antiviral activity of carrageenan, and can obviously improve the sustained-release effect of the gel and can maintain effective drug concentration for above 12 hours in the vagina in vivio. The preparation has the advantages of convenient drug administration and favourable sustained release and is suitable for treating diseases of female reproductive system, in particular to sexually transmitted sex microorganism infection.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a bioadhesive in-situ gel slow-release preparation for vaginal administration and a preparation method thereof. Background technique [0002] Inflammation of the female reproductive system is a common disease in gynecology. The infection can occur in the lower reproductive tract, such as vulvitis, vaginitis, and cervicitis; it can also invade the upper reproductive tract, that is, the internal genitalia, causing pelvic inflammatory disease. According to relevant statistics, 70% of adult women in my country have gynecological inflammation in varying degrees. At present, it is worth noting that reproductive tract viral infections and sexually transmitted diseases are on the rise, which not only threaten the health of women themselves but also harm their offspring. Pathogens can cause intrauterine infections through the placenta, birth canal infections during childbirth, and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K47/32A61K47/34A61P15/00A61K31/522A61K31/4164A61K31/4375A61K31/085A61K47/10
Inventor 刘瑜陆伟跃魏刚
Owner FUDAN UNIV
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