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Nose temperature-sensitive type hydrogel spray

A temperature-sensitive, hydrogel technology, used in allergic diseases, aerosol delivery, medical preparations with inactive ingredients, etc. Extended residence time, less irritating, easy-to-obtain results

Inactive Publication Date: 2014-04-09
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, considering that the cilia movement of the nasal mucosa is a protective barrier of the body itself, the gel formed should not be too strong, otherwise it will not only cause a foreign body sensation in the nasal cavity, but also may hinder the recovery of nasal cilia movement and cause new diseases. disease

Method used

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  • Nose temperature-sensitive type hydrogel spray
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  • Nose temperature-sensitive type hydrogel spray

Examples

Experimental program
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Effect test

Embodiment 1

[0029] Example 1 Phenylephrine Hydrochloride Nasal Thermosensitive Gel Spray I

[0030] Weigh 1.0% phenylephrine hydrochloride and 0.5% polylysine, add to the prescribed amount of water while stirring, dissolve and cool at 4°C. Weigh 0.5% poloxamer 188 and 17% poloxamer 407, and add them into the above cooled solution while stirring. After stirring well, keep it at 4°C until a clear solution without bubbles is formed. Wherein each component weight percent is as follows:

[0031]

Embodiment 2

[0032] Example 2 Phenylephrine Hydrochloride Nasal Thermosensitive Gel Spray II

[0033] Weigh 1.0% phenylephrine hydrochloride, 0.5% sodium hyaluronate (MW: 11000Da), 0.5% methylparaben, add to the prescribed amount of water while stirring, dissolve and cool at 4°C. Weigh 0.8% poloxamer 188 and 17% poloxamer 407, add to the above cooled solution while stirring, after stirring thoroughly, keep it at 4°C until a clear solution without bubbles is formed. Wherein each component weight percent is as follows:

[0034]

Embodiment 3

[0035] Embodiment 3 xylometazoline hydrochloride nasal temperature-sensitive gel spray

[0036] Weigh 0.1% xylometazoline hydrochloride and 1.5% sodium hyaluronate (MW: 11000Da), add to the prescribed amount of water while stirring, dissolve and cool at 4°C. Weigh 1.5% poloxamer 188 and 18% poloxamer 407, add to the above cooled solution while stirring, after stirring thoroughly, keep it at 4°C until a clear solution without bubbles is formed. Wherein each component weight percent is as follows:

[0037]

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Abstract

The invention belongs to the field of medicinal preparations and relates to a nose temperature-sensitive type hydrogel spray which is prepared by dissolving a nasal decongestant, an anti-allergic rhinitis drug, a temperature-sensitive type material of poloxamer and a low viscosity bioadhesive material without mucosal toxicity into water. A gel preparation is prepared from gel temperature, the viscosity of the preparation in use is considered simultaneously, the temperature sensibility and sprayable performance of the preparation are ensured, then the preparation doses in a liquid spray manner at the room temperature (25 DEG C), the preparation is translated into semisolid gel with suitable intensity after being contacted with nasal mucosa surface, and the preparation is delayed on the nasal mucosa surface for a long time with the mucosa adhesion action of the bioadhesive. By utilizing the nose temperature-sensitive type hydrogel spray, patient medication is convenient. Compared with a common nasal cavity spray, by utilizing the nose temperature-sensitive type hydrogel spray, the residence time of the drug in a nose cavity can be prolonged so as to increase local absorption of the drug and prolong the pesticide effect.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a temperature-sensitive hydrogel preparation with nasal spray as the final administration form and a preparation method thereof. Background technique [0002] The nose is the most important olfactory organ of the human body. While sensing the outside world, it is also more vulnerable to foreign harmful substances or sensitizing substances, which can cause common diseases such as nasal congestion and allergic rhinitis. Due to its special physiological structure, the nasal cavity will affect the normal work of other organs. For example, nasal congestion may cause ear discomfort, interfere with hearing, and affect pronunciation. Severe nasal congestion may cause insomnia and even sleep apnea. The preparations for the treatment of nasal congestion and allergic rhinitis that have been marketed mainly include oral (such as tablets) and nasal administration (such as nasal drops,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K45/00A61K47/34A61K47/36A61P11/02A61P37/08
Inventor 涂家生徐晓枫
Owner CHINA PHARM UNIV
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