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Method for improving hemostatic effect of external-use zeolite hemostat by calcium ion modification

A technology of calcium ion and hemostatic agent, which is applied in the field of zeolite hemostatic agent for external use, can solve the problems of inconvenient treatment, high requirements for natural zeolite selection, and many preparation processes, and achieve good hemostatic effect, high hemostatic effect, and easy process steps Effect

Inactive Publication Date: 2010-05-12
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Zeolite hemostatic agent Quikclot can absorb water and release heat at a maximum temperature of about 100°C. Animal experiments have shown that it can cause significant thermal damage to the skin, muscles, nerves, blood vessels and adipose tissue around the trauma of experimental animals, so it is very inconvenient for further treatment after hemostasis
[0004] Chinese patent application number 200810063282.4 provides a preparation method of a modified natural zeolite emergency life-saving hemostatic agent, which requires the natural zeolite soaking, ammonization, ion exchange, heat treatment and other treatment processes. The improved material has a good hemostatic effect and heat release less, but this preparation method has many preparation process steps and has high requirements for the selection of natural zeolite

Method used

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  • Method for improving hemostatic effect of external-use zeolite hemostat by calcium ion modification

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Effect test

Embodiment 1

[0019] Select 5A zeolite, 4A zeolite, 3A zeolite, Y zeolite, synthetic mordenite, synthetic 13X zeolite, and synthetic beta-zeolite, and put a certain amount of zeolite into a traditional Chinese medicine grinder, and the crushing time is about 5 minutes. The diameter is between 1 micron and 1 mm, and the pulverized zeolite is dried in an oven at 100° C. for 1 h. Its hemostatic effect diagram is attached figure 1 and 2 .

Embodiment 2

[0021] Take a certain amount of pulverized 5A zeolite and calcium chloride solution, mix uniformly at room temperature according to the ratio of 1g: 10ml, the concentration of calcium ions in the calcium chloride solution is 5mol / L, react at 100°C for 6h for ion exchange, Then filter, dry and grind to obtain 5A zeolite hemostatic agent. After calcium ion exchange, the hemostatic performance of zeolite has been greatly improved, which is close to that of the commercial hemostatic agent Quikclot. The hemostatic effect after calcium ion exchange is shown in the appendix figure 1 .

Embodiment 3

[0023] According to the preparation method of Example 2, the difference is that the zeolite is selected as the synthetic 4A zeolite, the calcium ion-containing solution is a calcium chloride solution, and the concentration of calcium ions in the solution is 5mol / L to obtain a 4A zeolite hemostatic agent for external use. See the hemostatic effect diagram attached figure 1 .

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Abstract

The invention relates to a method for improving the hemostatic effect of external-use zeolite hemostat by calcium ion modification, comprising the steps of using 5A zeolite, 4A zeolite, 3A zeolite, combined Y zeolite, synthesized mercerizing zeolite, synthesized 13x zeolite and synthesized beta-zeolite as the materials, grinding the materials into particles with the grain diameter of 1 micro to 1 mm with a traditional Chinese medicine grinder, mixing the grinded zeolite and the calcium ion solution in which the concentration of the calcium ion is 0.1-10 mol / L in the solid-to-liquid ratio of 1 g:10 ml, reacting for 3-6 h at a temperature of 60-120 DEG C, washing till no calcium ion is available in the eluate, and then drying at a temperature of 60-200 DEG C to obtain the external-use zeolite hemostat with better hemostatic effect.

Description

technical field [0001] The invention relates to a zeolite hemostatic agent for external use, and relates to a method for improving the hemostatic effect of the zeolite hemostatic agent for external use by modifying calcium ions. Background technique [0002] Emergency life-saving hemostatic agent is an emerging research field in the world. Emergency life-saving hemostats are primarily developed for emergencies where bleeding does not stop in trauma. An emergency like aortic bleeding can be contained within a short period of time (3 minutes), gaining valuable time for further medical treatment. [0003] The Quikclot hemostatic material provided by Z-Medica is a composite zeolite hemostatic material based on 75% synthetic zeolite (type A zeolite, LTA structure) and 25% clay as a binder. Quikclot hemostatic material The effect is outstanding, but Quikclot has obvious side effects of water absorption and heat release. Zeolite hemostatic agent Quikclot can absorb water and rel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/06A61K33/00A61P7/04A61L15/44
Inventor 范杰李云龙肖丽萍邢瑜卿靳加彬
Owner ZHEJIANG UNIV
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