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Application of total flavonoids aglycon extract of baical skullcap root in preparation of medicament for preventing and treating pulmonary fibrosis

A technology of total flavonoid aglycone and pulmonary fibrosis, applied in the field of medicine, can solve the problems of pulmonary fibrosis that have not yet been seen, and achieve the effect of reducing fibroblast proliferation, reducing lung coefficient, and reducing the degree of pulmonary fibrosis

Inactive Publication Date: 2010-06-16
苏州中药研究所有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

"(Zhang Yongyi et al.: A preparation method and application of total flavonoid aglycone extract of Scutellaria baicalensis, application number: 200810204811.8, June 17, 2009 AD), but so far, no total flavonoid aglycone extract of Scutellaria baicalensis has been used in Literature Report on Prevention and Treatment of Pulmonary Fibrosis

Method used

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  • Application of total flavonoids aglycon extract of baical skullcap root in preparation of medicament for preventing and treating pulmonary fibrosis
  • Application of total flavonoids aglycon extract of baical skullcap root in preparation of medicament for preventing and treating pulmonary fibrosis
  • Application of total flavonoids aglycon extract of baical skullcap root in preparation of medicament for preventing and treating pulmonary fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] 1.1 Purpose of the experiment: To observe the effect of the total flavonoid aglycone extract of Scutellaria baicalensis on the body weight and lung coefficient of mice with pulmonary fibrosis induced by BLM

[0038] 1.2 Experimental materials

[0039] Experimental animals: 90 Kunming mice, both ♀ and ♂, weighing 18-22 grams, clean grade, provided by the Animal Experiment Center of Soochow University. Experimental animal use license number: SYXK (Su) 2007-0035. Experimental animal production license number: SCXK (Su) 2007-0007.

[0040] Experimental drug: Scutellaria baicalensis total flavonoid aglycone extract (total flavonoid aglycone content ≥ 50%), batch number: 090424, brownish yellow powder, extracted by the phytochemical laboratory of this research institute according to the existing technology, stored in a refrigerator at 4°C, and used before use Dissolved in 5% carboxymethylcellulose sodium (CMC-Na); bleomycin A5 (BLM A5), white freeze-dried powder, 15mg / bottl...

Embodiment 2

[0056] 2.1 Purpose of the experiment: To observe the effect of the total flavonoid aglycone extract of Scutellaria baicalensis on the SOD activity, MDA content and the ability to inhibit OH in the serum of mice with pulmonary fibrosis induced by BLM

[0057] 1.2 Experimental materials

[0058] Experimental animals: 90 Kunming mice, both ♀ and ♂, weighing 18-22 grams, clean grade, provided by the Animal Experiment Center of Soochow University. Experimental animal use license number: SYXK (Su) 2007-0035. Experimental animal production license number: SCXK (Su) 2007-0007.

[0059] Experimental drug: Scutellaria baicalensis total flavonoid aglycone extract (total flavonoid aglycone content ≥ 50%), batch number: 090424, brownish yellow powder, extracted by the phytochemical laboratory of this research institute according to the existing technology, stored in a refrigerator at 4°C, and used before use Dissolved in 5% carboxymethylcellulose sodium (CMC-Na); bleomycin A5 (BLM A5), w...

Embodiment 3

[0077] 3.1 Purpose of the experiment: To observe the effect of Scutellaria baicalensis total flavonoid aglycone extract on SOD activity, MDA content and T-AOC in lung tissue of mice with pulmonary fibrosis induced by BLM

[0078] 3.2 Experimental materials

[0079] Experimental animals: 90 Kunming mice, both ♀ and ♂, weighing 18-22 grams, clean grade, provided by the Animal Experiment Center of Soochow University. Experimental animal use license number: SYXK (Su) 2007-0035. Experimental animal production license number: SCXK (Su) 2007-0007.

[0080] Experimental drug: Scutellaria baicalensis total flavonoid aglycone extract (total flavonoid aglycone content ≥ 50%), batch number: 090424, brownish yellow powder, extracted by the phytochemical laboratory of this research institute according to the existing technology, stored in a refrigerator at 4°C, and used before use Dissolved in 5% carboxymethylcellulose sodium (CMC-Na); bleomycin A5 (BLM A5), white freeze-dried powder, 15m...

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Abstract

The invention discloses application of a total flavonoids aglycon extract of baical skullcap root in the preparation of a medicament for preventing and treating pulmonary fibrosis. The invention adopts a technical scheme that: by internally instilling bleomycin AS (BLM A5) in the weasand, a mouse pulmonary fibrosis animal model is copied; the total flavonoids aglycon extract (the content of total flavonoids aglycon is more than or equal to 50 percent) of the baical skullcap root is selected as the treatment medicament for the first time; the interference effect of the total flavonoids aglycon extract of the baical skullcap root on biochemical indexes associated with the serum and the lung tissue of the pulmonary fibrosis animal model and the influence of the total flavonoids aglycon extract of the baical skullcap root on the pathomorphism of the lung tissue are observed to provide an experiment evidence for the treatment of pulmonary fibrosis diseases by the total flavonoids aglycon extract of the baical skullcap root. The medicament is a medicament prepared by combining a therapeutically effective amount of the total flavonoids aglycon extract of the baical skullcap root and a pharmaceutically acceptable vector.

Description

technical field [0001] The present invention relates to the application of an extract of the effective part of a traditional Chinese medicine in the preparation of a drug for preventing and treating pulmonary fibrosis, in particular to the application of the effective part of the traditional Chinese medicine Scutellaria baicalensis, the total flavonoid aglycone extract of Scutellaria baicalensis, in the preparation of a drug for preventing and treating pulmonary fibrosis , belonging to the field of medical technology. Background technique [0002] Pulmonary (interstitial) fibrosis (Pulmonary fibrosis, PF), also known as interstitial lung disease (Interstitiallung disease, ILD), is a common outcome of acute and chronic lung diseases caused by various causes. The etiology is complex, and it is now believed that it may be related to genetic susceptibility, viral infection, abnormal immune function, environmental pollution, drugs and chemicals, and radiation. About 50% of ILD i...

Claims

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Application Information

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IPC IPC(8): A61K36/539A61P11/00
Inventor 顾振纶蒋小岗郅玲然郭次仪周忠继
Owner 苏州中药研究所有限公司
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