Application of total flavonoids aglycon extract of baical skullcap root in preparation of medicament for preventing and treating pulmonary fibrosis
A technology of total flavonoid aglycone and pulmonary fibrosis, applied in the field of medicine, can solve the problems of pulmonary fibrosis that have not yet been seen, and achieve the effect of reducing fibroblast proliferation, reducing lung coefficient, and reducing the degree of pulmonary fibrosis
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[0036] Example 1
[0037] 1.1 Experimental purpose: To observe the effect of the total flavonoid aglycone extract of Scutellaria baicalensis Georgi on the body weight and lung coefficient of BLM-induced pulmonary fibrosis mice
[0038] 1.2 Experimental materials
[0039] Experimental animals: 90 Kunming mice, both ♀ and ♂, weighing 18-22 grams, clean grade, provided by the Animal Experiment Center of Soochow University. Laboratory animal license number: SYXK (Su) 2007-0035. Laboratory animal production license number: SCXK (Su) 2007-0007.
[0040] Experimental drug: Scutellaria baicalensis total flavonoid aglycone extract (total flavonoid aglycone content ≥50%), batch number: 090424, brown powder, extracted by the plant chemical laboratory of our institute according to existing technology, stored in a refrigerator at 4°C, and used before use 5% sodium carboxymethyl cellulose (CMC-Na) dissolved; bleomycin A5 (BLM A5), white freeze-dried powder, 15mg / piece, manufactured by Nippon Kaya...
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[0055] Example 2
[0056] 2.1 Experimental purpose: To observe the effect of the total flavonoid aglycone extract of Scutellaria baicalensis Georgi on the serum SOD activity, MDA content and the ability to inhibit ·OH in mice with BLM-induced pulmonary fibrosis
[0057] 1.2 Experimental materials
[0058] Experimental animals: 90 Kunming mice, both ♀ and ♂, weighing 18-22 grams, clean grade, provided by the Animal Experiment Center of Soochow University. Laboratory animal license number: SYXK (Su) 2007-0035. Laboratory animal production license number: SCXK (Su) 2007-0007.
[0059] Experimental drug: Scutellaria baicalensis total flavonoid aglycone extract (total flavonoid aglycone content ≥50%), batch number: 090424, brown powder, extracted by the plant chemical laboratory of our institute according to existing technology, stored in a refrigerator at 4°C, and used before use 5% sodium carboxymethyl cellulose (CMC-Na) dissolved; bleomycin A5 (BLM A5), white freeze-dried powder, 15mg...
Example Embodiment
[0076] Example three
[0077] 3.1 Experimental purpose: To observe the effects of the total flavonoid aglycone extract of Scutellaria baicalensis Georgi on SOD activity, MDA content and T-AOC in lung tissue of BLM-induced pulmonary fibrosis mice
[0078] 3.2 Experimental materials
[0079] Experimental animals: 90 Kunming mice, both ♀ and ♂, weighing 18-22 grams, clean grade, provided by the Animal Experiment Center of Soochow University. Laboratory animal license number: SYXK (Su) 2007-0035. Laboratory animal production license number: SCXK (Su) 2007-0007.
[0080] Experimental drug: Scutellaria baicalensis total flavonoid aglycone extract (total flavonoid aglycone content ≥50%), batch number: 090424, brown powder, extracted by the plant chemical laboratory of our institute according to existing technology, stored in a refrigerator at 4°C, and used before use 5% sodium carboxymethyl cellulose (CMC-Na) dissolved; bleomycin A5 (BLM A5), white freeze-dried powder, 15mg / piece, manufact...
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