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Application of osthole in preparation of medicament for preventing and treating myocardial fibrosis

A technology of myocardial fibrosis and osthole, which is applied in the direction of drug combination, active ingredients of heterocyclic compounds, cardiovascular system diseases, etc., can solve problems such as no reports of osthole, and achieve strong effect and strong anti-myocardial fiber effect

Inactive Publication Date: 2010-07-21
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] But so far there is no report on the relationship between osthole and myocardial fibrosis

Method used

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  • Application of osthole in preparation of medicament for preventing and treating myocardial fibrosis
  • Application of osthole in preparation of medicament for preventing and treating myocardial fibrosis
  • Application of osthole in preparation of medicament for preventing and treating myocardial fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1. Test drug

[0026] Osthole, white powder, purity 95%, provided by Xi'an Lvquan Biotechnology Co., Ltd., batch number 061227. Before use, use 0.5% sodium carboxymethylcellulose solution to prepare drug concentrations of 0.4% and 0.8%, respectively.

[0027] 2. Experimental animals

[0028] Kunming mice, male, weighing 22-25 g, supplied by the Experimental Animal Center of Soochow University, clean grade, experimental animal production license: SCXK (Su) 2007-0007, experimental animal use license: SYXK (Su) 2007-0035. During the experiment, the temperature of the feeding room was 20±2°C.

[0029] 3. Experimental method

[0030] Take 50 male Kunming mice and randomly divide them into 5 groups, 10 in each group. They are the normal control group and the myocardial fibrosis model group respectively. Group. The administration group was intragastrically administered with different doses of 0.1ml / 10g body weight for 3 days in advance, and the normal control group and th...

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Abstract

The invention relates to the novel use of osthole, in particular to the application of the osthole in the preparation of a medicament for preventing and treating myocardial fibrosis, and in particular discloses a medicinal composition for preventing and treating the myocardial fibrosis. The medicament for preventing and treating the myocardial fibrosis takes the osthole as an active constituent, also comprises one or more universal medicinal auxiliary components and can be made into tablets, capsules, medicinal granules, drops, granules or injection by adding the universal medicinal auxiliary components into the over 95 mass percent osthole. In the invention, as the osthole is applied to the preparation of the medicament for preventing and treating the myocardial fibrosis, the medicament has relatively stronger myocardial fibrosis resisting effect.

Description

technical field [0001] The invention relates to a new application of osthole, in particular to the application of osthole in the preparation of drugs for preventing and treating myocardial fibrosis. Background technique [0002] Myocardial fibrosis is often induced by diseases such as rheumatic heart disease, hypertension, myocardial infarction, and heart failure, which can lead to a decrease in ventricular compliance and seriously affect the normal systolic and diastolic functions of the heart. Drugs used to treat myocardial fibrosis mainly include angiotensin-converting enzyme inhibitors, angiotensin receptor antagonists, endothelin receptor antagonists, aldosterone receptor antagonists, antioxidants, calcium antagonists, and β-receptor antagonists. Among these drugs, only angiotensin-converting enzyme inhibitors and angiotensin receptor antagonists have good curative effects, but they still cannot completely antagonize the occurrence of myocardial interstitial fibrosis. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/37A61P9/04
Inventor 谢梅林陈蓉薛洁
Owner SUZHOU UNIV
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