Novel nerve protective agent

A neuroprotective agent and dosage technology, which is applied in cardiovascular system diseases, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of inseparable signal pathways, side effects of normal physiological functions, etc., achieve strong protective effects, reduce Cerebral infarct volume and effect of reducing neurological damage
CN101797386BInactive Publication Date: 2013-09-04张东才
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
张东才
Publication Date
2013-09-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a novel nerve protective agent, which belongs to the technical field of nerve protective medicine. The novel nerve protective agent comprises one kind or two kinds or three kinds of the following ingredients and contents: (1) antioxidants (with the dosage between 2.0 and 200 mg / kg); and (2) calcium ion antagonists (with the dosage between 1.0 and 400 mg / kg); and (3) adenosine diphosphate RNA polymerase inhibitors (with the dosage between 2.0 and 300 mg / kg). The invention carries out multi-blockage on the neurotrosis induced by free radicals in an acute phase of hypoxic-ischemic brain damage. Particularly, when three kinds of anti-oxygen free radicals-anti-inter-cell calcium ion overloading-PARP inhibitors are in combined use, the invention provides the protective effect on the acute phase damage of the ishemic stroke from multiple levels and multiple target points. Compared with a single protective agent, the compounded protective agent has stronger protective effect on both the in-vivo oxidative stress damage and the in-vitro oxidative stress damage of the ishemic stroke, and has good treatment effect on the hemorrhagic stroke.
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Description

Technical field

[0001] The invention belongs to the technical field of neuroprotective drugs, and particularly relates to a novel compound neuroprotective agent against ischemic stroke injury. Background technique

[0002] With the increase in average life expectancy and changes in lifestyle, the incidence of stroke has shown an upward trend in recent years, especially ischemic stroke; at present, ischemic stroke is one of the most fatal diseases in China. Among them, 80% of strokes are caused by embolism or thrombus obstruction of cerebral blood vessels, resulting in temporary or permanent reduction of cerebral blood flow, which in turn leads to the formation of cerebral infarction. Among the survivors, 30% of patients have severe sequelae due to cerebral infarction, such as vascular dementia and corresponding limb disorders.

[0003] Studies have found that in the acute phase of cerebral ischemia (within 72 hours), effective intervention in the pathological process of cerebral i...

Claims

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