Organ preservation solution and preparation method thereof

A technology of organ preservation solution and water for injection, which is applied in the field of organ preservation solution and its preparation, can solve problems such as obstacles, and achieve the effects of high repeatability, stable production process, and low production cost

Active Publication Date: 2010-08-18
HUAREN PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the lack of a long-acting multi-organ preservation solution similar to or better than UW solution in my country, in a sense, it limits and hinders the development of other large

Method used

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  • Organ preservation solution and preparation method thereof
  • Organ preservation solution and preparation method thereof
  • Organ preservation solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

Table 1 for the formulation of each 1000ml organ preservation solution of the present invention:

Table 1

Because the organ preservation solution of the present invention is weakly alkaline, dextran-40 is unstable for long-term high-temperature sterilization in a weakly alkaline environment, and light and oxygen also affect acetylcysteine, so this product uses a double-chamber bag (first , Two-chamber) packaging, that is, Dextran-40 is in the first chamber, and the rest of the ingredients are in the second chamber. There is a weakly welded partition between the adjacent chambers. The product outsourcing is torn off during use, and the product is squeezed. The weak welding partition in the middle is opened, so that the liquid medicine in the first and second chambers are mixed evenly, and then it can be used.

The ratio in the first chamber:

500ml of A solution in the first chamber, of which dextran-4020g, the remainder is water for injection;

Proportion in the second chamber: ...

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Abstract

The invention provides an organ preservation solution and a preparation method thereof, which are characterized in that every 1000ml of organ preservation solution contains: 21 to 29mmol of potassium citrate, 6 to 10mmol of sodium dihydrogen phosphate, 30 to 45mmol of disodium hydrogen phosphate, 4 to 6mmol of magnesium sulfate, 1 to 3mmol of potassium chloride, 16 to 24g of dextran-40, 110 to 150mmol of mannitol, 4 to 6mmol of adenosine, 4 to 6mmol of acetylcysteine, 4 to 6mmol of sodium hydroxide, and the balance water for injection. The organ preservation solution is packaged by a dual-chamber bag, wherein the dextran-40 in the organ preservation solution is arranged in a first chamber and other components are arranged in a second chamber, and a weak welding separation belt is arranged between the adjacent chambers. The organ preservation solution has good stability and lower cost; and the organ preservation solution preparation method has simpler and more reasonable process, and is applicable to large-scale production.

Description

A kind of organ preservation solution and preparation method thereof technical field The invention belongs to the technical field of medical equipment and medical biology, and relates to a preservation solution of organ tissues or cells of a human body or an animal, specifically an organ preservation solution and a preparation method thereof. Background technique Human organ transplantation technology started in the early 20th century, after a hundred years of arduous exploration, it has become an effective and routine means to treat the end-stage of organ failure. In particular, organ transplantation technology in developed countries has become a new discipline in the medical field, and has achieved fruitful results and great progress. People's dependence on organ transplantation is increasing day by day. In the United States, every 16 minutes, one person joins the ranks of waiting for organ transplantation. In my country, there are 200,000 new uremia patients every year....

Claims

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Application Information

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IPC IPC(8): A01N1/02
Inventor 杜光张春强方建国孙怡贺国芳叶芳姜汉英王波马永贵宫念樵陈知水
Owner HUAREN PHARMACEUTICAL CO LTD
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