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Medicament for treating hyperprolactinemia and preparation method thereof

A technology for hyperprolactinemia and drugs, applied in drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve problems such as increased serum prolactin, achieve reasonable preparation methods, good social and economic benefits Effect

Active Publication Date: 2010-08-25
SHANDONG INST OF PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to solve and make up for the existing clinical premenstrual tension syndrome and infertility accompanied by increased serum prolactin, which belongs to the shortage of traditional Chinese medicines due to liver stagnation, heat, yin and blood deficiency, and only western medicine bromocriptine in clinical practice. questions that can be used

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The traditional Chinese medicine medicine provided by the invention is made up of the raw material of following weight ratio:

[0023] Bupleurum 200g White peony 500g Angelica 200g Cyperus cyperus 200g Moutan bark 300g Gardenia 300g

[0024] Rose 300g Malt 2000g Eclipta 200g Ligustrum 200g

[0025] Described dosage form is granule, and the processing step of preparation method is as follows:

[0026] Ten medicinal materials in the prescription, extract volatile oil from Rhizoma Cyperi and Angelica, extract paeonol from Cortex Moutan, and collect the distilled aqueous solution and dregs in a separate device; combine the volatile oil and paeonol extracted above, and encapsulate them with α-cyclodextrin ; Bupleurum and other seven flavors, add water to decoct twice, add 14 times the amount of water for the first time, and decoct for 2 hours; add the above medicinal residues for the second time, add 12 times the amount of water, decoct for 1 hour, combine the decoction, fi...

Embodiment 2

[0028] Bupleurum 200g White peony 500g Angelica 200g Cyperus cyperus 200g Moutan bark 300g Gardenia 300g

[0029] Rose 300g Malt 2000g Eclipta 200g Ligustrum 200g

[0030] Described dosage form is granule, and the processing step of preparation method is as follows:

[0031] Ten medicinal materials in the prescription, extract volatile oil from Rhizoma Cyperi and Angelica, extract paeonol from Moutan cortex, and collect the distilled aqueous solution and medicinal residues in a separate device; combine the above-mentioned extracted volatile oil and paeonol, and wrap them with β-cyclodextrin ; Bupleurum and other seven flavors, add water to decoct twice, add 14 times the amount of water for the first time, and decoct for 2 hours; add the above medicinal residues for the second time, add 12 times the amount of water, decoct for 1 hour, combine the decoction, filter . The filtrate is combined with the above aqueous solution, concentrated to a relative density of 1.08-1.20 (60°C...

Embodiment 3

[0033] Bupleurum 400g White peony 500g Angelica 400g Cyperus 400g Peony bark 300g Gardenia 300g

[0034] Rose 300g Malt 2000g Eclipta 400g Ligustrum 400g

[0035] Described dosage form is granule, and the processing step of preparation method is as follows:

[0036] Ten medicinal materials in the prescription, extract volatile oil from Rhizoma Cyperi and Angelica, extract paeonol from Cortex Moutan, and collect the distilled aqueous solution and dregs in a separate device; combine the volatile oil and paeonol extracted above, and encapsulate them with α-cyclodextrin ; Bupleurum and other seven flavors, add water to decoct twice, add 14 times the amount of water for the first time, and decoct for 2 hours; add the above medicinal residues for the second time, add 14 times the amount of water, decoct for 1 hour, combine the decoction, filter . The filtrate is combined with the above aqueous solution, concentrated to a relative density of 1.10-1.14 (60°C) clear paste; spray-dried ...

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Abstract

The invention relates to a Chinese medicament for treating hyperprolactinemia and a preparation method thereof. The medicament is prepared from ten Chinese medicinal materials, namely radix bupleuri, white peony roots, angelica, nutgrass galingale rhizome, cortex moutan radicis, gardenia, roses, malt, herba ecliptae and glossy privet fruits. The medicament has the efficacy in soothing liver, relieving upset, nourishing Yin and blood, clearing heat and relieving restlessness, and is used for premenstrual tension syndrome, infertility accompanied by serum prolactin increase, as well as people with liver depression, heat transformation, deficiency of yin-fluid and blood. Symptoms include irregular menstruation, amenorrhea, no impregnation long after marriage, painful chest and hypochondrium or mammary swelling pain, light headedness, vexation, irascibility, agrypnia, dreaminess, mouth-throat dryness, waist-knee lassitude, red tongue with thin yellow fur or thin white dry fur and string-like rapid pulse. Clinical verification results show that the medicament is safe, effective and free from toxic or side effects on human bodies.

Description

Technical field [0001] The invention belongs to the technical field of preparation of medicines, and relates to a medicine for treating hyperprolactinemia prepared from Chinese herbal medicines and a preparation method of the medicine. Background technique [0002] Due to the development of radioimmunoassay technology, the number of patients diagnosed with hyperprolactinemia (HPRL) has increased significantly. In gynecological diseases, such as galactorrhea and breast lobular hyperplasia, PRL is often accompanied by elevated PRL. It is also found that long-term use of contraceptives Can lead to increased PRL. In recent years, it has been reported that the positive rate of HPRL in early cervical cancer is 65.8%. HPRL has caused great suffering to women, affecting their work and health. At present, the only effective western medicine used to treat hyperprolactinemia at home and abroad is imported bromocriptine, which is expensive, has large side effects, and is difficult for...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8998A61P15/00A61P15/08A61P5/00
Inventor 王燕张兰英郭琪张岱州李秀珍
Owner SHANDONG INST OF PHARMA IND
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