Compound lidocaine emulsifiable paste and preparation method thereof

A lidocaine and cream technology, applied in ointment delivery, pharmaceutical formula, emulsion delivery, etc., can solve problems such as unstable product quality, long production cycle, and low production efficiency, so as to save equipment investment and enhance safety sexual effect

Active Publication Date: 2010-09-01
北京中泰邦医药科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0012] The purpose of this invention is to provide a kind of compound lidocaine emulsifiable paste and preparation method thereof, to solve the high energy consumption in the production process of existing compound recipe lidocaine emulsifiable paste, long production cycle, low production efficiency, unstable product quality and Technical Issues of Safety in Clinical Application

Method used

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  • Compound lidocaine emulsifiable paste and preparation method thereof
  • Compound lidocaine emulsifiable paste and preparation method thereof
  • Compound lidocaine emulsifiable paste and preparation method thereof

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Embodiment Construction

[0098] A compound lidocaine cream: every 10 kg contains the following components by weight:

[0099] Lidocaine 50g~1000g;

[0100] Prilocaine 50g~1000g;

[0101] Polyoxyethylene hydrogenated castor oil 10g~500g;

[0102] Carbomer 10g~300g;

[0103] Sodium hydroxide 40g~200g;

[0104] Purified water was added to 10kg.

[0105] The best embodiment of compound lidocaine cream: 10 kg contains the following components by weight:

[0106] Lidocaine 250g;

[0107] Prilocaine 250g;

[0108] Polyoxyethylene hydrogenated castor oil 190g;

[0109] Carbomer 934NF 100g;

[0110] Sodium hydroxide 40g;

[0111] Add purified water to 10kg;

[0112] For the working process of the present invention, see figure 1 Shown: A preparation method of compound lidocaine cream, the steps are as follows:

[0113] Step 1. Pre-soak Carbomer 934 with purified water for at least 10 hours;

[0114] Step 2: Put the base lidocaine and the base prilocaine into a stirring vessel at a weight ratio of 1:1, and stir and mix at room tem...

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Abstract

The invention discloses a compound lidocaine emulsifiable paste and a preparation method thereof. Each 10kg of the compound lidocaine emulsifiable paste comprises the following components according to the weight: 50-1000g of base lidocaine, 50-1000g of base prilocainum, 10-500g of polyoxyethylene hydrogenated castor oil, 10-300g of Carbomer, 40-200g of sodium hydroxide and the balance of pure water. The invention increases clinical use security through releasing lidocaine and prilocainum in base modes to the subcutaneous layer with the depth of 5mm without containing a penetrating agent or a surface active agent component, which is particularly suitable for children patients and patients for face beauty. Through improvement on production process steps, the invention enables the production operation to become easy and feasible, is easy to control the product quality and increases the product stability. The whole production cycle is only half day, and the production efficiency is improved by more than 3 times, thereby the raw materials are saved and the production cost is reduced.

Description

technical field [0001] The invention relates to a medical cream and a preparation method thereof. Background technique [0002] The traditional compound lidocaine cream needs to add penetrants, such as: azone and surfactants such as: Tween 80, etc. Its purpose is to destroy the epidermal tissue of the skin to increase the subcutaneous penetration effect. But it is harmful to the skin like this, and the purpose of safe medication cannot be achieved. Tween 80 has a strong effect of breaking cell membranes and causing irritation. The medical community has confirmed that Tween 80 can cause allergic reactions, including shock, dyspnea, hypotension, angioedema, and urticaria and other allergic-like reaction symptoms. These adverse reactions can be very serious in human clinical trials, with deaths reported. Therefore, there are strict restrictions on the use of Tween 80. It is a potentially unsafe auxiliary material, and improper use will have a great impact on human health. T...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/167A61P31/04A61K9/06
Inventor 鲍亚华
Owner 北京中泰邦医药科技有限公司
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