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Anesthetic anti-inflammatory pharmaceutical composition used for bronchofiberscope surgery of pneumonia child patient and anesthetic anti-inflammatory method

An anti-inflammatory drug and bronchoscopy technology, applied in the field of anesthesia, can solve the problems of injury and increase the difficulty of liver metabolism in children, and achieve the effects of simple drug ingredients, reducing the production of inflammatory factors in the lungs, and facilitating recovery

Pending Publication Date: 2020-12-25
CHANGZHOU CHILDRENS HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, excessive use of drugs increases the difficulty of liver metabolism in children, causing irreparable damage

Method used

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  • Anesthetic anti-inflammatory pharmaceutical composition used for bronchofiberscope surgery of pneumonia child patient and anesthetic anti-inflammatory method
  • Anesthetic anti-inflammatory pharmaceutical composition used for bronchofiberscope surgery of pneumonia child patient and anesthetic anti-inflammatory method
  • Anesthetic anti-inflammatory pharmaceutical composition used for bronchofiberscope surgery of pneumonia child patient and anesthetic anti-inflammatory method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] According to the child's weight, configure 2mg / kg propofol and lactated Ringer's solution to make intravenous injection, 1.5 μg / kg dexmedetomidine and normal saline to make intravenous drip according to body weight; The concentration of propofol in the intravenous infusion was 10 mg / mL; the concentration of dexmedetomidine in the intravenous infusion was 4 μg / mL.

[0019] The anesthesia and anti-inflammatory pharmaceutical composition is given by intravenous injection, and the drug active ingredient is administered at a speed of 0.6-2.5 μg / kg / 10 min 10 minutes before the intravenous injection, and the speed of administration after 10 minutes is 0.2-1.0μg / kg / h; the active ingredient in the first 10 minutes is to make the blood drug concentration in the child reach the loading dose, and the active ingredient is injected after 10 minutes to maintain the blood drug concentration in the child. The body weight is 10 kg, and the intravenous injection rate of the drug active in...

Embodiment 2

[0021] According to the weight of the child, configure 2mg / kg propofol and lactated Ringer's solution to make an intravenous injection, and 1 μg / kg dexmedetomidine and normal saline to make an infusion according to the body weight; The concentration of pophenol is 10 mg / mL; the concentration of dexmedetomidine in the intravenous infusion is 4 μg / mL.

[0022] The anesthetic and anti-inflammatory pharmaceutical composition is administered through intravenous injection.

Embodiment 3

[0024] According to the weight of the child, 2 μg / kg of fentanyl and lactated Ringer’s solution were configured according to the body weight to make an intravenous injection, and 1 μg / kg of dexmedetomidine and normal saline were used to make an infusion; The concentration of tanyl was 30 μg / mL; the concentration of dexmedetomidine in the intravenous infusion was 4 μg / mL.

[0025] The anesthetic and anti-inflammatory pharmaceutical composition is administered through intravenous injection.

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Abstract

The invention belongs to the technical field of anesthesia, and relates to an anesthetic anti-inflammatory pharmaceutical composition used for bronchofiberscope surgery of a pneumonia child patient and an anesthetic anti-inflammatory method. The composition consists of active pharmaceutical ingredients and a pharmaceutically acceptable carrier, and the active pharmaceutical ingredients include oneor more of 1.5-2.5mg / kg propofol, 1.5-2.5[mu]g / kg of fentanyl and 0.5-1.0 [mu]g / kg of remifentanyl and 0.5-2 [mu]g / kg dexmedetomidine. The anesthetic anti-inflammatory method is to administrate a therapeutically effective amount of an anesthetic anti-inflammatory pharmaceutical composition. The composition has simple pharmaceutical ingredients; the dexmedetomidine and the propofol have the anesthetic anti-inflammatory synergistic effect; and extra anti-inflammatory drugs do not need to be used in the bronchofiberscope surgery of the pneumonia child patient, thus facilitating recovery of the patient, and enhancing the medication safety.

Description

technical field [0001] The invention belongs to the technical field of anesthesia, and in particular relates to an anesthesia and anti-inflammation pharmaceutical composition and an anesthesia and anti-inflammation method for bronchoscopic surgery on children with pneumonia. Background technique [0002] Fiberoptic bronchoscopy is an endoscopic technique for diagnosing and treating respiratory diseases. It has little tissue trauma and can directly visualize endotracheal lesions. It has been widely used clinically. Refractory pneumonia and atelectasis in children are common respiratory diseases in clinical pediatrics. The disease is often protracted. The application of fiberoptic bronchoscope can directly look at the lesion to make the etiological diagnosis, and can reduce local inflammation and promote lung recruitment through lavage. . Due to the poor cooperation of infants and young children, in order to ensure the safety of the operation, most of the children in clinical...

Claims

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Application Information

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IPC IPC(8): A61K31/4468A61K31/05A61K31/4174A61P29/00A61P23/00A61P11/00
CPCA61K31/4468A61K31/05A61K31/4174A61K9/0019A61P29/00A61P23/00A61P11/00A61K2300/00
Inventor 匡荣郑爱斌江凯华易阳韩军吴家麟赵乐怿董芳芳
Owner CHANGZHOU CHILDRENS HOSPITAL
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