Compound lidocaine emulsifiable paste and preparation method thereof

A technology for lidocaine and cream, applied in ointment delivery, pharmaceutical formula, emulsion delivery, etc., can solve the problems of long production cycle, unstable product quality, high energy consumption, etc., to enhance safety and save equipment investment Effect

Active Publication Date: 2011-06-29
北京中泰邦医药科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0012] The purpose of this invention is to provide a kind of compound lidocaine emulsifiable paste and preparation method thereof, to solve the high energy consumption in the production process of existing compound recipe lidocaine emulsifiable paste, long production cycle, low production efficiency, unstable product quality and Technical Issues of Safety in Clinical Application

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  • Compound lidocaine emulsifiable paste and preparation method thereof
  • Compound lidocaine emulsifiable paste and preparation method thereof
  • Compound lidocaine emulsifiable paste and preparation method thereof

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Embodiment Construction

[0096] A kind of compound lidocaine emulsifiable paste: contain following component by weight in every 10 kilograms:

[0097] Lidocaine 50g~1000g;

[0098] Prilocaine 50g~1000g;

[0099] Polyoxyethylene hydrogenated castor oil 10g~500g;

[0100] Carbomer 10g~300g;

[0101] Sodium hydroxide 40g~200g;

[0102] Purified water was added to 10kg.

[0103] The best embodiment of compound lidocaine cream: every 10 kilograms contains the following components calculated by weight:

[0104] Lidocaine 250g;

[0105] Prilocaine 250g;

[0106] Polyoxyethylene hydrogenated castor oil 190g;

[0107] Carbomer 934 NF 100g;

[0108] Sodium hydroxide 40g;

[0109] Add purified water to 10kg;

[0110] Working process of the present invention sees figure 1 Shown: a kind of preparation method of compound lidocaine cream, its steps are as follows:

[0111] Step 1, pre-soak Carbomer 934 with purified water for at least 10 hours;

[0112] Step 2, putting base lidocaine and base prilocaine ...

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Abstract

The invention discloses a compound lidocaine emulsifiable paste and a preparation method thereof. Each 10kg of the compound lidocaine emulsifiable paste comprises the following components according to the weight: 50-1000g of base lidocaine, 50-1000g of base prilocainum, 10-500g of polyoxyethylene hydrogenated castor oil, 10-300g of Carbomer, 40-200g of sodium hydroxide and the balance of pure water. The invention increases clinical use security through releasing lidocaine and prilocainum in base modes to the subcutaneous layer with the depth of 5mm without containing a penetrating agent or a surface active agent component, which is particularly suitable for children patients and patients for face beauty. Through improvement on production process steps, the invention enables the productionoperation to become easy and feasible, is easy to control the product quality and increases the product stability. The whole production cycle is only half day, and the production efficiency is improved by more than 3 times, thereby the raw materials are saved and the production cost is reduced.

Description

Technical field [0001] The invention involves a medical cream and its preparation methods. Background technique [0002] Traditional compound riberine cream needs to be added with osmotic agents, such as: nitrogen ketones and surfactants such as: Twen 80.The purpose is to destroy the skin epidermis tissue to increase the infiltration effect of the subcutaneous.However, this is damaged to the skin and cannot achieve the purpose of safe medication.Twen 80 has a strong function of rupture cell membranes and causes irritation. The medical community confirms that Twen 80 can cause allergic reactions, including allergic symptoms such as shock, dyspnea, hypertension, vascular edema, and rubella.These adverse reactions can be very serious in clinical experiments and reports.Therefore, the use of Twen 80 has strict restrictions. It is an auxiliary material with potential unsafe. Improper use will have a great impact on human health.The viral reaction generated by this will exceed the bene...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/167A61P31/04A61K9/06
Inventor 鲍亚华
Owner 北京中泰邦医药科技有限公司
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