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Bone-knitting qili compound and preparation method thereof

A composition and drynaria technology, applied in drug combination, active ingredients of boron compounds, bone diseases, etc., can solve the problems that single ingredients cannot guarantee the curative effect of drugs, and cannot fully represent the efficacy of prescriptions, etc.

Active Publication Date: 2010-09-29
湖南金沙药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, domestic compound preparations of traditional Chinese medicine generally only control a single index in the single medicinal material that is easy to measure in the preparation, and there is no scientific research on the contribution of the medicinal effect to the index that should be controlled in the prescription, and a single index component cannot It fully represents the efficacy of the prescription, and the efficacy of the drug cannot be guaranteed by controlling individual ingredients

Method used

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  • Bone-knitting qili compound and preparation method thereof
  • Bone-knitting qili compound and preparation method thereof
  • Bone-knitting qili compound and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] Experiment on the Effects of Quaint Jiegu Qili Composition on Promoting Fracture Healing

[0081] 1. Experimental materials:

[0082] 1.1. Tested drug: 10 kinds of taste-less bone-bone seven-percent composition.

[0083] The whole composition of medicinal materials

[0084] Frankincense (fried) 10g, myrrh (fried) 10g, angelica 15g, wood beetle 25g, drynaria drynaria 15g, borax 10g, dragon's blood 15g, natural copper (calcined) 10g, rhubarb (wine fried) 10g, the whole recipe 120g in total.

[0085] Tasteless sample preparation

[0086] Steps for preparing the sample of Jiegu Qili lack of taste: ①Crush each medicinal material separately and pass through an 80-mesh sieve. ②Except for the lack of flavor medicinal materials, the remaining medicinal materials are weighed and mixed according to the amount of the whole prescription, and microcrystalline cellulose is added to make up 120g, combined and grinded until uniform.

[0087] Sample group 1 (lack of frankincense)

...

Embodiment 2

[0109] Effects of frankincense with different quality requirements on fracture healing effect of Jieguqili Composition

[0110] According to the main effects of Jieguqili preparation for promoting blood circulation, removing blood stasis and relieving pain, the relevant chemical components in frankincense were analyzed, and the quantitative index represented by 11-carbonyl-β-acetylboswellic acid was selected. as a grade indicator. The frankincense medicinal materials are divided into five grades: (1) TLC identification meets the requirements, and the content of 11-carbonyl-β-acetylboswellic acid is greater than 2.0%; (2) TLC identification meets the requirements, and the content of 11-carbonyl-β-acetylboswellic acid between 1.0% and 2.0%; (3) TLC identification meets the requirements, the content of 11-carbonyl-β-acetylboswellic acid is between 0.5% and 1.0%; (4) TLC identification meets the requirements, 11-carbonyl- The content of β-acetylboswellic acid is lower than 0.5%; ...

Embodiment 3

[0124] Effect of myrrha with different quality requirements on fracture healing effect of Jieguqili Composition

[0125] According to the main efficacy of the bone qili preparation, the relevant chemical components in myrrh were analyzed, and β-elemene was selected as a representative as a quantitative index. Divided into five grades: (1) The TLC identification meets the requirements, and the content of β-elemene is greater than 0.4%; (2) The TLC identification meets the requirements, and the β-elemene is between 0.2% and 0.4%; (3) The TLC identification meets the requirements, and the content of β-elemene is between 0.1% and 0.2%; (4) The TLC identification meets the requirements, and the content of β-elemene is less than 0.1%; (5) The TLC identification does not meet the requirements .

[0126] 1. Experimental materials:

[0127] 1.1. Tested drug: 5 groups of whole prescription bone seven cents composition

[0128] Frankincense (fried) 10g, myrrh (fried) 10g, angelica 15g...

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Abstract

The invention relates to a traditional Chinese medicine compound, in particular to a bone-knitting qili compound and a preparation method thereof. The bone-knitting qili compound provided by the invention comprises native copper, ground beetle, rhizome drynariae, resina draconis, frankincense, myrrh, angelica, rhubarb and borax. The invention compares the main efficacy of the bone-knitting qili compound without single medicinal material and the full prescription compound, i.e. catagmatic effectiveness, finds that six medicinal materials of frankincense, myrrh, rhizome drynariae, resina draconis and the like play an important role in compound efficacy. The invention also creatively selects the main controllable efficacy ingredients in the six medicinal materials, and the ingredients are taken as the basis for identifying quality. By using the medicinal materials with different standard limits to prepare the bone-knitting qili compound to carry out efficacy comparison, the result shows that the bone-knitting qili compound prepared from any one single or multiple medicinal material(s) which satisfies (satisfy) a certain standard limit has obvious better efficacy than the compound which does not meet the requirement.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a composition and a preparation method thereof. Background technique [0002] Acute soft tissue sprains and fractures are common clinical diseases in orthopedics and traumatology. With the increasing number of work-related injuries and traffic accidents, the incidence rate is increasing year by year. There is an urgent need for safe and effective internal and external drugs. The treatment of this type of disease mainly adopts traditional Chinese medicine (Chinese patent medicine) or surgical therapy. At present, there are many Chinese patent medicines for the treatment of this type of disease in China, but there are few varieties with quick effect, definite curative effect and short course of treatment. The bone bone Qili preparation described in the present invention is a traditional Chinese medicine protection variety Jiegu Qili tablet exclusively produced by Hunan ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61K9/14A61K9/20A61K9/48A61P19/08G01N30/02A61K35/64A61K33/26A61K33/22
Inventor 周应军徐瑾陈正收
Owner 湖南金沙药业有限责任公司
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