Ointment for treating cheek erythema

A technology for erythema and cheeks, applied to medical preparations containing active ingredients, plant raw materials, skin diseases, etc., can solve the problems of troublesome preparation, complicated ointment formula, and unsatisfactory curative effect, and achieve convenient portability and stable and reliable curative effect Effect

Active Publication Date: 2010-10-27
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CN1175451 discloses a lupus erythematosus ointment, but the ointment has complex formula, troublesome preparation, difficult preservation and unsatisfactory curative effect

Method used

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  • Ointment for treating cheek erythema
  • Ointment for treating cheek erythema
  • Ointment for treating cheek erythema

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] [embodiment 1] preparation of ointment of the present invention

[0030] 1) Weigh 25g of comfrey, 50g of lingxiaohua, 50g of Danpi, 50g of Sophora flavescens, 50g of Angelica dahurica, 50g of white poria cocos, and 50g of Baixianpi for later use;

[0031] 2) Add 6 times the amount of vegetable oil to comfrey, soak it at 60°C for more than 2 hours, and filter to get the oil solution;

[0032] 3) Reflux Lingxiaohua with 50% ethanol, each time for one hour, a total of 3 times, take the alcohol extract and concentrate it with alcohol;

[0033] 4) Add 6 times the amount of distilled water to the Danpi decoction pieces, soak them in a water bath at 40°C for 2 hours, then add absolute ethanol, distill and reflux with water vapor, take the reflux distillate, refrigerate overnight at 4°C, and collect crystals;

[0034] 5) Extract Sophora flavescens with water by water extraction and alcohol precipitation method, concentrate its extract, add appropriate ethanol or water to repea...

experiment example 1

[0041] [Experimental example 1] the influence of medicine of the present invention on rat foot plantar swelling

[0042] (1), materials and methods

[0043] 1. Experimental animal Male SD rat, (4-6 weeks old, body weight 100-200g, provided by Zhejiang Traditional Chinese Medicine Daxue Animal Experiment Center)

[0044] 2. Pharmaceutical reagents: ointment of the present invention, blank ointment; prepare inflammatory agent (10% egg white solution) with distilled water.

[0045] 3. Experimental instrument: YLS-7A foot and plantar volume measuring instrument

[0046] 4. Method:

[0047] Twelve male SD rats were randomly divided into 3 groups, drug group, blank group and control group.

[0048] Preparation of inflammation model: After measuring the volume of the normal paw of the hind right limb of each rat by the volumetric method, inject 10% egg white solution subcutaneously into the paw of each rat, with an injection volume of 0.1 ml / rat.

[0049] Control group: no treatm...

experiment example 2

[0077] [Experimental Example 2] Modeling of contact eczema in guinea pigs and the effects of medication

[0078] (1) Materials and methods:

[0079] 1. Experimental animals: guinea pigs, pure white short-haired, with an initial weight of 250g±20g, provided by the Animal Experiment Center of Zhejiang University of Traditional Chinese Medicine.

[0080] 2. Pharmaceutical reagents: ointment of the present invention, 5% dinitrochloropropiophenone solution

[0081] 3. Experimental method: According to the literature method, 12 guinea pigs were established as a contact eczema model. The nape of each guinea pig was clipped with a size of 2×2 cm, and 100 μl of 5% dinitrochloropropiophenone (DNCB) solution was used as an excitation, once a week for 4 consecutive times. After the third challenge, the skin of the right ear was slightly thickened with a little desquamation; after the fourth challenge, the skin of the right ear was obviously thickened, which was similar to the clinical m...

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Abstract

The invention relates to a medicament for treating cheek erythema and a preparation method thereof. The medicament which can be absorbed well and stored for a long term, has stable curative effect and can directly act on the skin and mucosa is prepared by purifying various active ingredients of different medicaments and mixing the active ingredients further by reasonable preparation technology. The medicament is used for treating the cheek erythema in lupus erythematosus. A large number of animal experiments prove that the medicament has the advantages of no toxic or side effect and reliable curative effect.

Description

technical field [0001] The invention relates to a medicine for treating buccal erythema and a preparation method thereof, belonging to the field of traditional Chinese medicines. Background technique [0002] Lupus erythematosus is an autoimmune disease with slow onset and insidious occurrence, and various and changing clinical manifestations. The disease can affect multiple systems and organs in the body, and a variety of autoantibodies can be found in the patient's blood and organs. Lupus erythematosus is divided into discoid lupus erythematosus (DLE), systemic lupus erythematosus (SLE), subacute cutaneous lupus erythematosus, deep lupus erythematosus and other types. In addition to the typical discoid erythema in discoid lupus erythematosus, patients with lupus also have butterfly erythema, erythema multiforme, annular erythema, bullous erythema, and some discoid erythema. More than 80% of the patients had skin lesions, erythema, and rashes in various types. In addition...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/75A61P37/02A61P17/00
Inventor 范永升
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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