30 results about "Erythema multiforme" patented technology

The present invention provides a method of predicting the risk of a patient for developing adverse drug reactions, particularly SJS or TEN. It was discovered that an HLA-B allele, HLA-B* 1502, is associated with SJS / TEN that is induced by a variety of drugs. The correlation with HLA-B* 1502 is most significant for carbamazepine-induced SJS / TEN, wherein all the patients tested have the HLA-B* 1502 allele. In addition, another HLA-B allele, HLA-B*5801, is particularly associated with SJS / TEN induced by allopurinol. Milder cutaneous reactions, such as maculopapular rash, erythema multiforme (EM), urticaria, and fixed drug eruption, are particularly associated with a third allele, HLA-B *4601. For any of the alleles, genetic markers (e.g., HLA markers, microsatellite, or single nucleotide polymorphism markers) located between DRB1 and HLA-A region of the specific HLA-B haplotype can also be used for the test.

The present invention provides a method of predicting the risk of a patient for developing adverse drug reactions, particularly SJS or TEN. It was discovered that an HLA-B allele, HLA-B* 1502, is associated with SJS / TEN that is induced by a variety of drugs. The correlation with HLA-B* 1502 is most significant for carbamazepine-induced SJS / TEN, wherein all the patients tested have the HLA-B* 1502 allele. In addition, another HLA-B allele, HLA-B*5801, is particularly associated with SJS / TEN induced by allopurinol. Milder cutaneous reactions, such as maculopapular rash, erythema multiforme (EM), urticaria, and fixed drug eruption, are particularly associated with a third allele, HLA-B *4601. For any of the alleles, genetic markers (e.g., HLA markers, microsatellite, or single nucleotide polymorphism markers) located between DRB 1 and HLA-A region of the specific HLA-B haplotype can also be used for the test.

Disclosed are applications of a mussel adhesive protein or preparations thereof in suppression of skin inflammations. Specifically disclosed are applications of a mussel adhesive protein, preparations thereof and applications thereof in dermatitis, eczema, skin ulcer, technologies related to burns (comprising skin grafting), perniones, surgical incisions, herpes, abrasions, scars, psoriasis, erythema multiforme, skin damage after radiotherapy, skin cancers, folliculitis, urticaria and drug eruption, and applications in sunburn, polymorphous light eruption, pathological alopecia (comprising hair transplant), acne vulgaris, rosacea (that is, acne rosacea), and the like, and applications in the treatment of otitis externa.

The invention relates to a direct fluorescence labeling method for displaying a cryptocaryon irritans brown microtubule cytoskeleton structure, which comprises the following steps of: preparing a glass slide coated with polylysine; permeating cryptocaryon irritans brown cells through solution PHEM (Postherpetic Erythema Multiforme) containing saponin, and adding PHEM solution for immersion bath; fixing permeated cells through paraformaldehyde solution, and carrying out immersion bath through the PHEM solution, and transferring the fixed cells to the glass slide coated with the polylysine; dripping Triton X-100 water solution on the cells after removing extra fluid, carrying out immersion bath through the PHEM solution, and rinsing through 0.01mol / L of phosphate buffer; rinsing through 0.10mol / L of PBS (Phosphate Buffer Solution) after keeping from light, hatching through the PBS containing 1mu mol / L of fluorescence taxoid at room temperature, removing extra solution, and capping the glass slide; and finally, observing through a microscope and taking photos. The method is simple to operate, has high efficiency, is environmental-friendly and has no pollution.

The invention discloses an external medicine for treating autoimmune dermatosis and a preparation method and application thereof. The main ingredient of the external medicine is a NK cell stock solution, wherein the NK cell stock solution is obtained by performing multiplication culture on NK cells, the NK cell stock solution is mixed with different drug excipients, and an external liquid preparation or an external paste preparation can be prepared. Compared with the prior art, the external medicine contains anti-inflammatory and high-efficiency active factors, the active ingredients of the medicine can safely and effectively reach the lesions so as to eliminate the pathogenesis, and the effects of rapidly relieving pain and relieving symptoms can be achieved. After the medicine is used, a skin protection film can be formed, and injury repair is facilitated. The medicine has excellent effects on autoimmune dermatosis such as psoriasis, pityriasis rosea, erythema multiforme and the like, is convenient to use, does not have any toxic or side effect due to long-term use, and is also applicable to special crowds who are unsuitable to use other types of medicines and hormones, particularly people with skin allergy, infants, pregnant women and the like.

The invention discloses decoction medicine for treating erythema multiforme and a preparation method thereof. The medicine is prepared from, by mass, 1-3 parts of rehmanniae roots, 1-3 parts of peony tree root bark, 1-3 parts of lithospermum erythrorhizon, 1-3 parts of scutellaria baicalensis, 1-3 parts of Chinese parsnip roots, 1-3 parts of gentiana macrophylla, 1-3 parts of dittany bark, 1-3 parts of atractylodes macrocephala and 1-3 parts of poria; a pepartion method of the medicine comprises the steps of purchasing high-quality and clean first-grade rehmanniae roots, peony tree root bark, lithospermum erythrorhizon, scutellaria baicalensis, Chinese parsnip roots, gentiana macrophylla, dittany bark, atractylodes macrocephala and poria according to the mass ratio, picking out impurities and dust in all ingredients, placing the ingredients in a cloth bag, binding an opening of the bag, and leaving the ingredients for standby application; placing the wrapped medicine into cold cooled water for being immersed for a half hour, then placing the medicine which is immersed ready and clear liquor used for immersing the medicine into a drug-decocting machine together, inputting cold boiled water which is 35 mm higher than the medicine level, conducting decoction of the first time for 40 minutes, after liquid medicine is filtered and picked, inputting tepor boiled water which is 32 mm higher than the medicine level, conducting decoction of the second time for 35 minutes, mixing and concentrating the mixture into 1140 milliliters of liquid traditional Chinese medicine with the concentration being 50%, packaging and sealing the decoction medicine in bags, and placing the decoction medicine in a refrigerator for standby application.

The invention discloses traditional Chinese medicine effective part composition for treating the erythema multiforme. The traditional Chinese medicine composition comprises raw materials such as pyrola, caulis sinomenii, elecampane, muskroot-like semiaquilegia roots, rhizoma kaempferiae and golden larch bark in certain parts by weight. The traditional Chinese medicine effective part composition has effects of heat clearing, dampness drying, blood circulation promoting, stasis removing, warming the meridian to dissipate cold, ollateral vessels freeing, itching relieving, qi tonifying and blood activating, blood cooling and nutrient regulating and is effective in treatment of the erythema multiforme, free from side effects and high in safety.

The invention relates to a group of medicines for treating erythema multiforme, belongs to the technical field of medicines and aims at solving the problems of complex illness state and easy reoccurrence of the erythema multiforme. By analyzing the erythema multiforme from the angle of traditional Chinese medicine, the erythema multiforme is caused by spleen and lung weakness, entrance of wind toxicity in blood and stagnation of dampness and heat, occurs on skins and is treated by using combined traditional Chinese medicines capable of invigorating spleen, removing dampness, clearing heat, removing toxicity, dispelling wind and cooling blood as treatment medicines which comprise the following components in parts by weight: 15 parts of mung bean meal, 15 parts of unprocessed rehmannia root, 10 parts of honeysuckle bud and flower, 15 parts of scorpion, 10 parts of tree peony root bark, 15 parts of Chinese honeylocust spine, 10 parts of unprocessed malt, 10 parts of chrysanthemum flower, 10 parts of mustard seed, 15 parts of baical skullcap root, 10 parts of crystal pearl, 10 parts of barbary wolfberry fruit, 15 parts of weeping forsythia capsule, 15 parts of mulberry leaf and 10 parts of liquorice root. The curative effect of the group of medicines for treating erythema multiforme is remarkable, and the reoccurrence rate is low.

A pharmaceutical composition for prevention or treatment of a disease or disorder characterized by chronic inflammation, with associated angiogenesis and fibrosis, wherein the disease or disorder is selected from the group consisting of rosacea, psoriasis, erythema multiforme, bullous pemphigoid, hereditary hemorrhagic telangiectasia, rheumatoid arthritis, atopic dermatitis, and dermal wound healing. The pharmaceutical composition includes at least one multi-kinase inhibitor selected from the group consisting of axitinib, nintedanib, and lenvatinib.

Disclosed are applications of a mussel adhesive protein or preparations thereof in suppression of skin inflammations. Specifically disclosed are applications of a mussel adhesive protein, preparations thereof and applications thereof in dermatitis, eczema, skin ulcer, technologies related to burns (comprising skin grafting), perniones, surgical incisions, herpes, abrasions, scars, psoriasis, erythema multiforme, skin damage after radiotherapy, skin cancers, folliculitis, urticaria and drug eruption, and applications in sunburn, polymorphous light eruption, pathological alopecia (comprising hair transplant), acne vulgaris, rosacea (that is, acne rosacea), and the like, and applications in the treatment of otitis externa.

The invention relates to a traditional Chinese medicine decoction for treating erythema multiforme. The decoction comprises following components by weight: 13-17 g of radix scrophulariae, 18-22 g of isatis root, 23-27 g of dandelion, 10-14 g of cortex moutan, 8-12 g of cicada slough, 6-10 g of paris polyphylla, 14-18 g of rhizoma phragmitis, 7-11 g of cortex magnoliae officinalis and 10-14 g of rhizoma alismatis.

The invention discloses a formula of skin beautifying cream for treating urticaria. The skin beautifying cream is prepared from the following raw materials: radix angelicae sinensis, ramulus cinnamomi, radix codonopsis, antler gum, rhizoma chuanxiong, pericarpium citri reticulatae, charred medicated leaven, rhizoma dioscoreae, herba artemisiae capillariae, fructus alpiniae oxyphyllae, fructus piperis alba, fructus psoraleae, fructus jujubae, white paeony root, radix rehmanniae preparata, tortoise-shell glue, radix bupleuri, stir-baked rhizoma polygonati with yellow rice wine, rhizoma zingiberis recens, fructus corni, fructus lycii, herba taxilli, semen allii tuberosi, herba asari, radix astragali seu hedysari, cortex cinnamomi, safflower, rhizoma atractylodis, cortex eucommiae, poria cocos, folium artemisiae argyi, semen cuscutae, fructus evodiae, rhizoma cyperi, yellow rice wine, arillus longan, brown sugar, semen sesami nigrum and semen juglandis. The skin beautifying cream is mainlyused for treating the blood deficiency and cold coagulation type urticaria; due to the correlation of physical constitution, the starting point of treatment starts from the physical constitution; theskin beautifying cream can also be used for treating multiple diseases such as refractory eczema, angiitis, postherpetic neuralgia, urticaria, allergic purpura, erythema multiforme, Raynaud's disease, rhagadia of hands and feet, chilblain, psoriasis vulgaris, parapsoriasis, arthromyodynia, dysmenorrhea, hysteromyoma and dysmenorrheal which belong to blood deficiency and cold coagulation type symptoms.

The invention relates to medicinal liquor for controlling cold-type erythema multiforme, which belongs to the technical field of a health care drink. The medicinal liquor is composed of 8 bulk drugs of peach kernels, rose flower, ginger, broom cypress fruit, and balloonflower root and the like, and the raw materials are prepared to obtain the medicinal liquor. The medicinal liquor has the functions of warming yang and dispelling cold, promoting blood circulation and removing blood stasis, and benefiting kidney and removing spot, and has good effect on preventing and treating cold-type erythemamultiforme. The medicinal liquor is convenient to take, and is safe and effective.

The invention discloses an oral liquid for treating wind-cold type erythema multiforme, and belongs to the technical field of traditional Chinese medicine preparations. Ten kinds of bulk drugs, such as medicinal evodia fruit, red peony root, dried ginger, fineleaf schizonepeta herb and Chinese dates, are mainly prepared into a liquid medicine for orally taking. The oral liquid has functions of warming yang for dispelling cold, activating blood circulation to dissipate blood stasis, tonifying kidney and removing spots and has good effects on treating wind-cold type erythema multiforme; and theoral liquid is convenient for taking, safe and effective.

The invention discloses a pill for treating wind-cold type erythema multiforme, and belongs to the technical field of traditional Chinese medicine preparations. The pill is mainly prepared from 11 kinds of raw materials such as red peony root, radix astragali, radix angelica sinensis, divaricate saposhnikovia root, poria cocos and fineleaf schizonepeta herb. The raw materials are prepared into thepill for taking. The pill has the functions of warming yang and dispelling cold, promoting blood circulation to remove blood stasis, tonifying kidney and removing freckles, and the effect of treatingwind-cold type erythema multiforme is good. The pill is convenient to take, safe and effective.

The invention relates to a slurry for prevention and treatment of wind-cold erythema multiforme, and belongs to the technical field of health care drinks. The slurry is mainly prepared from nine raw materials of ligusticum wallichii, radix aconiti carmichaeli, hematoxylon, a Chinese wild ginger root, folium artemisiae argyi, ginger and the like, and a syrup is made for taking. The slurry has the functions of warming yang and dispelling cold, promoting blood circulation and removing blood stasis and benefiting kidney and removing freckles, and has a good effect on the prevention and treatment of the wind-cold erythema multiforme. The slurry is convenient to take, safe and effective.

The invention provides an animal and plant tincture liquid for preventing and treating wind-cold type erythema multiforme and belongs to the technical field of health products. The tincture liquid ismainly prepared from 9 medicinal raw materials such as safflower carthamus, Chinese ephedra, schizonepeta, cicada slough and silkworm larva, and is externally used. The animal and plant tincture liquid has the functions of warming yang to dissipate coldness, promoting blood circulation to remove blood stasis, tonifying kidney and removing freckles, has the good effect of preventing and treating the wind-cold type erythema multiforme and is convenient to apply, safe and effective.

The invention provides a capsule for treating wind-cold type Erythema multiforme, belonging to the technical field of traditional Chinese medicine preparations. The capsule is mainly composed of ten bulk drugs consisting of spatholobus stems, cassia twigs, notopterygium roots, Radix Saposhnikoviae, dried orange peel, dried ginger and the like. The above ten bulk drugs are made into the capsule foradministration. The capsule has the functions of warming yang, dispelling cold, activating blood circulation to dissipate blood stasis, nourishing the kidney and removing spots, exerts good treatmenteffect on the wind-cold type Erythema multiforme, and is convenient, safe and effective to take.

The invention relates to an external use liquid medicine for preventing and treating cold-type erythema multiforme, which belongs to the technical filed of a health product. The external use liquid medicine is composed of radix aconiti carmichaeli, Radix Codonopsis, sappan wood, red sage root, Asarum Herb, and Artemisia argyi and the like, and the raw materials are prepared to the liquid medicinefor external use. The external use liquid medicine has the functions of warming yang and dispelling cold, promoting blood circulation and removing blood stasis, and benefiting kidney and removing spot, and has good effect on preventing and treating cold-type erythema multiforme. The external use liquid medicine is convenient to smear, and is safe and effective.

The invention relates to a spray liquid for preventing and treating erythema multiforme induced by cold and belongs to the technical field of healthcare products. The spray liquid is primarily prepared from the eight raw medicinal materials of flos sophorae, roses, periostracum cicada, fresh ginger, cortex moutan and the like which are prepared into the liquid medicine to be sprayed to the affected part. The spray liquid has the functions of warming yang for dispelling cold, promoting blood circulation to remove blood stasis and tonifying kidney and removing beverage, is good in effect of preventing and treating erythema multiforme induced by cold, and is convenient to spray and safe and effective.

The invention discloses a granular formula for treating wind-cold erythema multiforme, and belongs to the technical field of traditional Chinese medicine preparations. According to the formula, granules are mainly prepared from 11 active pharmaceutical ingredients such as radix codcnopsitis pilosulas, caulis spatholobi, ramulus cinnamomi, radix salviae miltiorrhizae, herba asari cum radice and rhizoma sinomeni cauliset, and the active pharmaceutical ingredients are prepared into the granules for being taken. The granules have the functions of warming yang for dispelling cold, promoting blood circulation to remove blood stasis, and tonifying the kidney to remove freckles, and have a good effect on treating wind-cold erythema multiforme. The granular composition is convenient to take, safe and effective.

The invention relates to a medicine for treating erythema multiforme.The medicine is prepared from, by weight, 9 parts of hiraute shiny bugleweed herb, 6 parts of beautiful sweetgum fruits, 20 parts of all-grass of shiningfruit night-shade, 1 part of radix kansui, 15 parts of herb of diffuse dayflower, 10 parts of radix tripterygii hypoglauci and 10 parts of root bark of Zanthoxylum simulans Hance.In application of the medicine, the herba lycopi has the effects of promoting blood circulation for removing blood stasis, inducing diuresis for diminishing swelling, and removing toxicity for eliminating carbuncles; the beautiful sweetgum fruits have the effects of dispelling wind and eliminating dampness, soothing the liver and activating collaterals, and inducing diuresis; the all-grass of shiningfruit night-shade has the effects of clearing away heat and toxic materials, and inducing diuresis and reducing edema; the radix kansui has the effects of removing retained water and morbid fluid, and dispersing stagnation and relaxing the bowels; the herb of diffuse dayflower has the effects of clearing away heat and toxic materials, inducing diuresis and reducing edema, and stopping bleeding; the radix tripterygii hypoglauci has the effects of dispelling wind and eliminating dampness, promoting blood circulation and arresting bleeding, relaxing muscles and tendons and setting fractures, and achieving detoxication and destroying intestinal worms; the root bark of Zanthoxylum simulans Hance.has the effects of clearing away heat and drying dampness, dispelling wind and arresting itching, and achieving detoxication.All the medicinal materials are used in cooperation, and the effects of warming channels and expelling cold, dredging collaterals and dispersing blood stasis, clearing away heat and toxic materials, and cooling blood and harmonizing ying are achieved.Clinical experiments prove that the medicine can safely and effectively treat erythema multiforme.

The invention discloses washing water for preventing and treating wind-cold type erythema multiforme, and belongs to the technical field of health products. Eight kinds of bulk drugs, such as cockcombinflorescence, radix aconiti lateralis preparata, manchurian wildginger, fresh ginger and belvedere fruit, are mainly prepared into the washing water to wash affected parts. The washing water has functions of warming yang for dispelling cold, activating blood circulation to dissipate blood stasis, tonifying kidney and removing spots, and has good effects on preventing and treating wind-cold typeerythema multiforme; and the washing water is convenient for washing, safe and effective.

The invention belongs to the technical field of Chinese medicine, and relates to a folium artemisiae argyi-contained Chinese medicine composition for treating cold erythema multiforme and preparation method thereof.The Chinese medicine composition is prepared from, by weight, 18-22 parts of folium artemisiae argyi, 16-20 parts of longhairy antenoron herbs, 15-19 parts of radix aconiti carmichaeli, 16-20 parts of tribulus terrestris, 11-15 parts of angelica sinensis, 10-14 parts of white peony root, 11-15 parts of lalang grass rhizome, 9-13 parts of fructus kochiae, 8-12 parts of tree peony bark, 8-12 parts of fructus forsythiae, 9-13 parts of Chinese taxillus herb and 7-11 parts of liquorice root.The Chinese medicine composition has the functions of clearing away heat and toxic materials, removing swelling and eliminating stasis, promoting blood circulation to remove blood stasis and warming channels to remove coldness, and has a remarkable treatment on cold erythema multiforme.

The invention discloses combined ointment for preventing and treating wind-cold type erythema multiforme, and belongs to the technical field of health products. Nine kinds of bulk drugs, such as ephedra herb, medicinal evodia fruit, radix salviae miltiorrhizae, fineleaf schizonepeta herb and periostracum cicadae, are mainly prepared into the ointment for external use. The ointment has functions ofwarming yang for dispelling cold, activating blood circulation to dissipate blood stasis, tonifying kidney and removing spots, and has good effects on preventing and treating wind-cold type erythemamultiforme; and the ointment is easy to apply, safe and effective.

The invention discloses a spraying liquid for preventing and treating wind-cold type erythema multiforme, and belongs to the technical field of health products. Eight kinds of bulk drugs, such as pagoda tree flower, rose flower, periostracum cicadae, fresh ginger and cortex moutan, are mainly prepared into a liquid medicine for externally spraying on affected parts. The spraying liquid has functions of warming yang for dispelling cold, activating blood circulation to dissipate blood stasis, tonifying kidney and removing spots, and has good effects on preventing and treating wind-cold type erythema multiforme; and the spraying liquid is convenient for spraying, safe and effective.

The invention discloses a tablet for treating wind-cold type erythema multiforme, and belongs to the technical field of traditional Chinese medicine preparations. Eleven kinds of bulk drugs, such as radix astragali, suberect spatholobus stem, white peony root, Chinese angelica, radix salviae miltiorrhizae, dried ginger and liquorice root, are mainly prepared into the tablet for taking. The tablethas functions of warming yang for dispelling cold, activating blood circulation to dissipate blood stasis, tonifying kidney and removing spots and has good effects on treating wind-cold type erythemamultiforme; and the tablet is convenient for taking, safe and effective.