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Li nation medicament extract and composition with bacteriostatic, anti-inflammatory and hemostasis effects and preparation method thereof

A technology for extracts and compositions is applied in the field of extracts, compositions and preparations of Viola chinensis, which can solve the problems of large dosage, poor controllability of quality standards, unacceptable, etc., and achieves concentrated active ingredients and methods The effect of scientific stability and simple process

Inactive Publication Date: 2010-11-24
海南省南药黎药研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are disadvantages such as large doses, unclear active ingredients, and poor controllability of quality standards, making it difficult to meet the requirements of "safe, effective, controllable, and stable" drugs
At present, although there are a variety of dosage forms that are convenient for patients to use, they are only simple dosage form conversions, and there is no substantial innovation in technology. Accepted by the international market

Method used

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  • Li nation medicament extract and composition with bacteriostatic, anti-inflammatory and hemostasis effects and preparation method thereof
  • Li nation medicament extract and composition with bacteriostatic, anti-inflammatory and hemostasis effects and preparation method thereof
  • Li nation medicament extract and composition with bacteriostatic, anti-inflammatory and hemostasis effects and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] The preparation example of embodiment 1 nude flower purple pearl extract

[0081] After pulverizing the leaves of Auranthus nudiflora, extract with solvent for 3 times, the amount of solvent added each time is 10-20 times of the amount of medicinal materials, and the extraction time is 3 hours each time. The extracts were combined and filtered, and the filtrate was concentrated under reduced pressure to obtain a crude extract; the crude extract was subjected to D101 adsorption resin column chromatography, and first eluted with 10 times the amount of water as the eluent to obtain the water-eluted part; then Use 15 times the amount of 10%-90% alcohol as the eluent to carry out gradient elution, collect the eluate from the alcohol washing part, concentrate under reduced pressure, and dry to obtain the alcohol eluate, which is the extract of Aurora nudica .

Embodiment 2

[0082] Example 2 A specific example of the preparation of the pharmaceutical composition tablet of the present invention.

[0083] Add 0.5-1 part of starch to 1 part of Li medicine extract obtained in Example 1, mix evenly, granulate, dry, granulate, add magnesium stearate, and compress into tablets to obtain tablets.

Embodiment 3

[0084] Embodiment 3 The preparation of pharmaceutical composition dispersible tablet of the present invention

[0085] With 1 part of Li medicine extract obtained in Example 1, add 0.5-1 part of starch as a diluent, add 0.5-1 part of microcrystalline cellulose as a disintegrant, and granulate the above mixture (over 20- 12 mesh), drying, adding an appropriate amount of magnesium stearate as a glidant, after mixing evenly, the powder is directly compressed into a tablet to obtain a dispersible tablet.

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PUM

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Abstract

The invention provides a Li nation medicament nakedflower beautyberry leaf extract with bacteriostatic, anti-inflammatory and hemostasis effects and a preparation method thereof, and a medicinal composition comprising the active extract. The extract and the medicinal composition comprising the extract are used for treating inflammation caused by bacterial infection, acute infectivity hepatitis, and bleeding of orifices such as the respiratory tract and the digestive tract, and do not have toxic or side effect. The extract can be prepared into any oral preparation for treating the inflammation caused by bacterial infection, the acute infectivity hepatitis, and the bleeding of orifices such as womb, vagina, the respiratory tract and the digestive tract.

Description

technical field [0001] The invention belongs to the field of ethnic medicines, and in particular relates to an extract, a composition, a preparation method and an application of the Li medicine Aurora nudiflora. Background technique [0002] Callicarpa nudiflora Hook.Et Arn. is a plant of the genus Callicarpa nudiflora Hook.Et Arn. in the family Verbenaceae. The leaves are used as medicine. It has the function of swelling and is a commonly used medicine for Li nationality compatriots in my country. [0003] At home and abroad, there are few reports on the chemical constituents of plants of the genus Auranthus genus, including Auranthus nudiflora. The chemical constituents mainly include flavonoids, terpenes, and volatile oils. The current technology is to decoct and extract the leaves of Auranthus nudiflora to obtain the extract, and then add auxiliary materials to make oral preparations such as tablets or capsules, which are used to treat inflammation caused by bacterial in...

Claims

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Application Information

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IPC IPC(8): A61K36/85A61P31/04A61P29/00A61P1/16A61P7/04A61K127/00
Inventor 刘明生董琳张俊清张鹏威
Owner 海南省南药黎药研究院
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