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Porous polymeric resins

A technology of porous polymers and resins, applied in separation methods, chemical instruments and methods, solid adsorbent liquid separation, etc., can solve problems such as impure products and low capacity

Inactive Publication Date: 2014-07-30
3M INNOVATIVE PROPERTIES CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The hydrophobic backbone of styrene / divinylbenzene copolymers is prone to nonspecific interactions with a variety of substances, resulting in impure products
Although cross-linked agarose resins are generally not susceptible to nonspecific interactions, these materials tend to be very soft gels and have relatively low capacities for many biomolecules

Method used

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Examples

Experimental program
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Effect test

example

[0198] These examples are for illustrative purposes only and are not intended to limit the scope of the appended claims. Solvents and other reagents used were obtained from Sigma-Aldrich Chemical Company (Milwaukee, WI) unless otherwise noted.

[0199] testing method

[0200] Cation Exchange Capacity of Immunoglobulin G (IgG)

[0201] A 50% by volume slurry of cation-exchange polymer beads was prepared by mixing the polymer beads with deionized water, centrifuging at 3000 relative centrifugal force (rcf) for 20 min to form a bead-packed bead bed, and then conditioning for deionization Amount of water such that the total volume is twice the packed bead bed. The slurry was mixed well to suspend the polymer beads, then a 400 microliter sample of the slurry was pipetted into a 0.45 micron pore size 5 mL cellulose acetate centrifugal microfilter available from VWR (Eagan, MN) was obtained commercially. Water was removed by centrifugation at 3000 rcf for 5 minutes. The poly...

example 1

[0211] Polymeric beads were prepared by reverse phase suspension polymerization using a monomer mixture comprising AMPS and MBA in a weight ratio of 35:65. Add PETROLITE D110 as organic aggregates to the aqueous phase.

[0212] More specifically, the organic phase was prepared by adding Suspending Agent 1 (0.56 g) and heptane (536 mL) into a flask equipped with a mechanical stirrer (stirring speed of 450 rpm), nitrogen inlet, thermometer, belt temperature Controller heating jacket and condenser. The organic phase in the flask was heated to 35° C. with stirring and sparged with nitrogen for 15 minutes.

[0213] Prepare the aqueous phase by combining: MBA (18.2 g), AMPS (19.6 g 50 wt% aqueous solution), IPA (85 mL), PETROLITE D110 (5 mL), deionized water (27.2 mL), PEG 6000 (10 g 50 wt % aqueous solution) and ethylene glycol (20 mL). The aqueous phase is stirred and heated at a temperature in the range of 30 to 35°C to dissolve the MBA. Stir again and add sodium persulfate (...

example 2-5

[0223] Polymeric beads were prepared by reverse phase suspension polymerization using a monomer mixture comprising AMPS and MBA in a weight ratio of 35:65. Various aqueous dispersions of organic aggregates were added to the aqueous phase. Example 2 contained UNITHOX D-100. Example 3 contained UNITHOX D-300. Example 4 contained PETROLITE D-800. Example 5 contained PETROLITE D-900.

[0224] More specifically, the organic phase was prepared by adding Suspending Agent 1 (0.56 g) and heptane (536 mL) into a flask equipped with a mechanical stirrer (stirring speed of 450 rpm), nitrogen inlet, thermometer, belt temperature Controller heating jacket and condenser. The organic phase in the flask was heated to 35° C. with stirring and sparged with nitrogen for 15 minutes.

[0225] An aqueous phase was prepared containing the following: MBA (18.2 g), AMPS (19.6 g of a 50 wt. ), PEG 6000 (10 grams of a 50% by weight aqueous solution) and ethylene glycol (20 mL). The aqueous solutio...

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Abstract

The present invention describes porous polymeric resins, reaction mixtures and methods useful for preparing the porous polymeric resins, and uses of the porous polymeric resins. More specifically, the polymeric resins typically have a hierarchical porous structure and reactive groups available to react or interact with a variety of different target compounds. The reactive groups may be selected from acid groups or salts thereof, amino groups or salts thereof, hydroxyl groups, azlactone groups, glycidyl groups or combinations thereof.

Description

technical field [0001] The present invention describes porous polymeric resins, methods and reaction mixtures for preparing the porous polymeric resins, and various uses of the porous polymeric resins. Background technique [0002] Polymeric resins are widely used in the isolation and purification of a wide variety of target compounds. For example, polymeric resins can be used to purify or isolate target compounds based on the presence or absence of ionic groups, the particle size of the target compound, hydrophobic interactions, affinity interactions, or the formation of covalent bonds. [0003] In the biotechnology industry, large-scale separation and / or purification of various biomolecules such as proteins, enzymes, vaccines, DNA, RNA is of great interest. The vast majority of polymer resins used for the isolation and purification of biomolecules are based on styrene / divinylbenzene copolymers or cross-linked agarose. The hydrophobic backbone of styrene / divinylbenzene co...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J9/26
CPCB01J20/261C08F226/06C08F228/02B01D15/00B01J20/26B01D15/08B01J20/267C08J2201/0462C08J2333/24C08J9/26B01J20/285C08F224/00C08J2333/04B01J20/28092
Inventor 彼得·D·维克特西蒙·K·香农凯南·塞沙德里杰拉尔德·K·拉斯穆森詹姆斯·I·亨布里小罗伯特·T·菲茨西蒙斯
Owner 3M INNOVATIVE PROPERTIES CO
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