Unlock instant, AI-driven research and patent intelligence for your innovation.
Medicament coating composition with masked taste
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A coating composition and drug coating technology, which is applied in drug delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problems of slow decrease in membrane permeability and decrease in drug bioavailability
Inactive Publication Date: 2013-06-12
钟术光
View PDF6 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
When the two different polymers have good compatibility, these micropores will slowly heal themselves during storage, which will gradually reduce the permeability of the coating film and reduce the bioavailability of the drug.
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0179] Coating (A) Paracetamol (APAP) made of 40% cellulose acetate, 20% Eudragit E 100 and 40% zinc phosphate particles (38~74μm particle size, or 200~400 mesh) Granules (14-24 meshes, the acetaminophen granules are prepared by dry granulation, and the composition is as follows: acetaminophen (APAP) 50%, microcrystalline cellulose 30%, cross-linked carboxymethyl Sodium cellulose 17%, sodium lauryl sulfate 1%, silicon dioxide 0.5%, sodium stearyl fumarate 1.5%) for coating, after the coating process, the coating accounted for 23.08% of the entire coated granules % (weight ratio) (ie 30% increase in particle weight). Then, the coated drug granules and other ingredients are mixed in the following proportions: coated granules 40.63%, mannitol 49.37%, microcrystalline cellulose 7.5%, stearic acid 1%, silica colloid 0.5%, fragrance 1%. The final blend was then compressed into tablets having a final tablet weight of 960 mg, such tablets having a diameter of 10.5 mm, a hardness of a...
Embodiment 2
[0206] Consists of 24% ethyl cellulose, 26% diethylaminomethyl cellulose, 49.5% L-cystine particles (23-38 μm in particle size, or 400-600 mesh) and 0.5% triacetin The prepared coating (B) is applied to pipemidic acid granules (12 to 20 meshes in diameter), and the pipemidic acid granules are prepared by dry granulation, and the content of the components is as follows: Microcrystalline cellulose 34%, low-substituted hydroxypropyl cellulose 18%, fructose 8%, lactose 8%, silicon dioxide 0.5%, sodium stearyl fumarate 1.5%. After the coating process was completed, the coating accounted for 23.08% by weight of the entire coated granules (ie, 30% granule weight gain). Then, the coated drug particles and other ingredients are mixed in the following proportions: 63.73% of coated particles, 26.27% of mannitol, 7.5% of microcrystalline cellulose, 1% of stearic acid, 0.5% of silica colloid, and 1% of fragrance. The final blend was then compressed into tablets having a final tablet weigh...
Embodiment 3
[0217] Consists of 38.56% KOLLIDONE SR, 20.0% vinyldiethylamine-vinyl acetate copolymer, 11.44% EASTMAN 9-45 (acetated monoglycerides), 25% potassium hydrogen tartrate particles (particle size The coating (A) made of 38-74 μm, or 200-400 mesh) and 5% talc is applied to drug caffeine particles (40-80 mesh in particle diameter).
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
PUM
Property
Measurement
Unit
particle size
aaaaa
aaaaa
solubility (mass)
aaaaa
aaaaa
solubility (mass)
aaaaa
aaaaa
Login to View More
Abstract
The invention discloses a medicament coating composition with improved comprehensive performance and masked taste hardly detected by a user. The medicament coating composition comprises: an outer coating, and a medicament core, wherein the outer coating contains a polymer which is not dissolved or hardly dissolved in water under any pH value, a polymer which is dissolved in an acidic medium but is not dissolved or hardly dissolved in a neutral or alkaline pH medium and a particulate matter which does not contain unpleasant odor, is not dissolved or hardly dissolved in water but can be dissolved in acidic medium and alkaline medium, and the medicament core is coated by the coating and contains unpleasant odor. The coating composition can stimulate the medicament to be released in the stomach and stimulate the medicament which is unreleased or incompletely released to enter the intestines to be released in the intestines so that the coating composition conveys the medicament contents tothe body system for more complete circulation and has higher medicament bioavailability.
Description
technical field [0001] The present invention relates to a pharmaceutical coating composition with peculiar smell not easily detected by users. Specifically, the present invention relates to a drug coating composition with improved comprehensive properties, which is difficult to be detected by the user, and the coating composition can not only promote the release of the drug in the stomach, but also promote the unreleased or unreleased drug in the stomach. The release in the intestine of the drug that enters the intestine without complete release allows the coated composition to deliver the drug component to the systemic circulation more completely, and the bioavailability of the drug is higher. technical background [0002] Many active ingredients, such as antibiotics, have strong unpleasant tastes such as bitter, spicy, astringent, etc. in terms of taste, and odor in terms of smell. Such unpleasant odors often have multiple adverse effects, for example, the unpleasant tast...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to View More