Trandolapril-containing compound preparation for curing hypertension

A compound preparation, the technology of trandolapril, which is applied in the field of medicine, can solve the problems of non-optimized proportioning, poor patient compliance, and low rate of blood pressure control, and achieve the goals of reducing adverse reactions, quick results, and high blood pressure rate. Effect

Active Publication Date: 2011-04-13
YUANHE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when several drugs are taken at the same time, the patient's compliance is poor, and the dosage of several drugs is often not the optimal ratio due to the problem of the dosage of the preparation and the degree of recognition of the doctor.
In recent years, although there are many new antihypertensive drugs with good efficacy and few side effects, the rate of blood pressure control is relatively low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-4

[0010] Embodiment 1-4 list is as follows:

[0011] In the embodiment, the conventional method in the pharmaceutical industry is used, and the formula shown in the table below is prepared into tablets, and the pharmaceutically acceptable carrier-adjuvant used for making the tablet is a conventional adjuvant in the art. Wherein the proportioning of its main components is as follows:

[0012]

[0013] Simultaneously, use conventional method in the pharmaceutical industry in the embodiment, can also be prepared into capsule, soft capsule, granule, powder, sustained and controlled release agent or injection dosage form, pharmaceutically acceptable carrier--all adjuvants used are the original formulations of this dosage form Common excipients in the field.

Embodiment 5

[0014] Embodiment 5: The curative effect test of the compound preparation of the present invention for treating hypertension:

[0015] The following will illustrate the therapeutic effect of the pharmaceutical composition of the present invention on hypertension through human pharmacodynamic experiments.

[0016] 1. General information:

[0017] Among the 400 clinical cases of hypertensive patients, 150 cases were 40-50 years old; 150 cases were 51-60 years old, and 100 cases were 61-70 years old.

[0018] 2. Diagnostic criteria: According to the "Guidelines for the Prevention and Treatment of Hypertension in China", hypertension is defined as: systolic blood pressure ≥ 140mmHg and / or diastolic blood pressure ≥ 90mmHg without taking antihypertensive drugs.

[0019] 3. Therapeutic method: 400 hypertensive patients are randomly divided into 4 groups, and each group adopts the compound preparation medicine obtained in Examples 1-4 of the present invention respectively to make ta...

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PUM

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Abstract

The invention provides a trandolapril-containing compound preparation for curing hypertension. The compound preparation comprises the following components: Levamlodipine or Levamlodipine pharmaceutical salt, hydrochlorothiazide and trandolapril or trandolapril pharmaceutical salt which serve as main components, as well as a pharmaceutical carrier serving as an auxiliary material, wherein in each preparation unit, the weight of the Levamlodipine or Levamlodipine pharmaceutical salt is 2.5-10.0mg. According to the mechanism of using drugs jointly to give full play to complementary actions of the drugs, the compound preparation has the advantages that the curative effect is enhanced, the standard can be reached rapidly, the blood pressure compliance rate is up to 82%, adverse reactions related to a certain increased dosage can be reduced, and the duration of time is longer; and the compound preparation has the characteristics of quick response, high blood pressure compliance rate, less side effect and low cost.

Description

Technical field: [0001] The invention relates to a compound preparation containing trandolapril for treating hypertension, which belongs to the field of medicines. Background technique: [0002] With the rapid growth of my country's economy, drastic changes in people's lifestyles, and the acceleration of urbanization and aging, cardiovascular disease has become the first or second cause of death in urban and rural populations. Especially the patients with hypertension, whose incidence rate accounts for about 15% of the total population. With such a large disease population, it is more important to seek therapeutic drugs with significant curative effect and less side effects. [0003] At present, there are many drugs for the treatment of hypertension, such as calcium antagonists (CCBs), converting enzyme inhibitors (ACEI), angiotensin Ⅱ receptor blockers (ARBs), etc., but it is difficult to achieve the target for a single drug treatment of hypertension in the short term , m...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K38/05A61P9/12A61K31/4422A61K31/549
Inventor邬林祥邬林云
OwnerYUANHE PHARMA CO LTD