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Gynecological disease resisting gel for treating gynecological disease and preparation method thereof

A gel technology for gynecological diseases and inflammation, applied in the field of gels for the treatment of gynecological diseases, can solve the problems of first-pass effect gastrointestinal irritation, single dosage form, etc., to reduce individual differences, reduce dosing frequency, and avoid first-pass effect Effect

Inactive Publication Date: 2011-04-27
贵州远程制药有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] For the treatment of gynecological diseases, Chinese Patent Publication No. 02127988.8 on September 1, 2004 disclosed a Kangfuyan capsule for the treatment of gynecological diseases. Drug first-pass effect and gastrointestinal irritation

Method used

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  • Gynecological disease resisting gel for treating gynecological disease and preparation method thereof
  • Gynecological disease resisting gel for treating gynecological disease and preparation method thereof
  • Gynecological disease resisting gel for treating gynecological disease and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Weigh 250g of sophora flavescens, 250g of barbarum sinensis, 150g of cortex phellodendri, 50g of forsythia, 30g of motherwort, 30g of red bean, 30g of mugwort leaf, 30g of angelica, and 30g of black medicine. Take 160g of the total amount of Sophora flavescens, 90g of the total amount of Phellodendron Phellodendri, 15g of the total amount of Forsythia, and 15g of the total amount of red beans, and grind them into fine powder for later use. Boil twice, the first time for 2 hours, the second time for 1 hour, combine the decoction and filter to obtain the filtrate, concentrate the filtrate to a thick paste with a relative density of 1.31-1.35 (60°C-80°C), add the above fine powder, mix;

[0064] Take carbomer, add water to swell, and make 0.5% glue solution, take 25g, add 25g of drug thick ointment, and add glycerin 10g under stirring (add water to make 30% solution), stir well to obtain anti-gynecitis gel Glue.

Embodiment 2

[0066] Take 225g of Sophora flavescens, 225g of Panguigui, 135g of Cortex Phellodendri, 45g of Forsythia, 27g of Motherwort, 27g of Red Bean, 27g of Artemisia argyi, 27g of Angelica, 27g of Black Yam, add water and decoct twice, the first time for 2 hours, and the second time for 1 hour , combined and decocted once, concentrated to a thick paste with a relative density of 1.31-1.35 (60°C-80°C), and dried to obtain the medicinal material extract.

[0067] Take carbomer, add water to swell, and make about 0.1% glue, take 50g, add 50g of drug extract, and add 40g of glycerin under stirring (add water to make a 30% solution), stir evenly to obtain anti-gynecitis Gel.

Embodiment 3

[0069] Take 165g of Phellodendron Phellodendron and 33g of Motherwort and reflux extract with 75% ethanol three times, each time for 1 hour, combine the ethanol extract, filter, recover the ethanol and concentrate it into a clear paste with a relative density of 1.25-1.30 (50°C) to obtain the ethanol extract . Take 275g of Sophora flavescens, 275g of Bangui, 55g of Forsythia, 33g of Artemisia argyi, 33g of Red Bean, 33g of Angelica, and 33g of Black Yam, add water and decoct twice, the first time for 2 hours, the second time for 1 hour, combine the decoction, filter After filtration, the filtrate was concentrated to a relative density of 1.25-1.30 (50°C) clear paste, combined with the above alcohol and water extraction clear paste, and dried to obtain the medicinal material extract.

[0070] Take carbomer, add water to swell, and make about 0.3% glue solution, take 30g, add 30g of drug extract, and add 20g of glycerin under stirring (add water to make a 30% solution), stir eve...

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Abstract

The invention discloses a gynecological disease resisting gel for treating gynecological disease and a preparation method. The gynecological disease resisting gel comprises the following components in parts by weight: 225-275 parts of radix sophorae flavescentis, 225-275 parts of polygonum perfoliatum, 135-165 parts of amur corktree bark, 45-55 parts of fructus forsythiae, 27-33 parts of motherwort herb, 27-33 parts of red bean, 27-33 parts of folium artemisiae argyi, 27-33 parts of Chinese angelica, and 27-33 parts of combined spicebush root. The preparation method of the gynecological disease resisting gel is as follows: crushing 160 parts of the total amount of the radix sophorae flavescentis, 90 parts of the total amount of the amur corktree bark, 15 parts of the total amount of the fructus forsythiae and 15 parts of the total amount of the red bean into fine powder for later use; adding water into nine medicine materials such as the rest of radix sophorae flavescentis, polygonum perfoliatum and the like, decocting for two times with the first time for 2 hours and the second time for 1 hour; combining decocted liquid, filtering to obtain filtered liquid, concentrating the filtered liquid to thick paste with the relative density of 1.31-1.35 at the temperature of 60-80 DEG C, adding the fine powder, and mixing uniformly; taking a medium, adding water for swelling, and preparing into 0.1-0.5% glue solution; and adding 2.5-5 parts of medicinal thick paste into 2.5-5 parts of glue solution, adding water under stirring, preparing into 1-4 parts of 30% wetting agent solution, and stirring uniformly, thus obtaining the gynecological disease resisting gel. By utilizing the invention, the dosing frequency can be greatly reduced, the treatment cycle is short, and the efficiency is high.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a gel for treating gynecological diseases, and also to a preparation method thereof. Background technique [0002] At present, for cervicitis, cervical erosion, the treatment of vaginitis mainly adopts physical therapy and drug therapy, and the commonly used means of physical therapy include electric ironing, laser therapy and cryotherapy. The basic principle is to cause necrosis and shedding of inflammatory tissue through physical factors, and then re-grow squamous epithelial tissue in the cervix. Although physical therapy can make the inflammatory tissue fall off and the cervical mucous membrane can be regenerated and repaired, it has side effects such as bleeding and watery exudation; it can also cause cervical canal stenosis and adhesion due to lymphatic tissue contraction; and it must be treated in a hospital, which is expensive and expensive. trouble. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/756A61K9/06A61P15/00
Inventor 刘青
Owner 贵州远程制药有限责任公司
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