New honeysuckle chlorogenic acid ester saponin as well as preparation method and use thereof

A technology of chlorogenic ester saponins and total saponins, which is applied in the field of natural medicinal chemistry and can solve the problem that COX-2 inhibitors cannot be used in clinical cancer chemotherapy
CN102050862BActive Publication Date: 2014-09-10INST OF BOTANY JIANGSU PROVINCE & CHINESE ACADEMY OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
INST OF BOTANY JIANGSU PROVINCE & CHINESE ACADEMY OF SCI
Publication Date
2014-09-10

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Abstract

The invention relates to the field of natural pharmaceutical chemistry and discloses a chemical structure of a new honeysuckle chlorogenic acid ester saponin compound which is extracted and separated from lonicera macranthodes hand-mazz buds, and the compound has the structure as shown in the right formula. The invention further relates a preparation method of the compound and a use of the compound in the field of medicine, in particular to a use of the compound in preparation of cycloxygenase II inhibitors, matrix metalloproteinase-9 inhibitors or anti-tumor drugs.
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Description

1. Technical field:

[0001] The invention relates to the field of natural medicinal chemistry, and discloses a new honeysuckle chloro orthoester saponin compound extracted and separated from the flower buds of Lonicera cinerea, as well as the preparation method of the compound and its application in the field of medicine, especially in the preparation of cyclic Use of an oxidase II inhibitor, a matrix metalloproteinase-9 inhibitor or an antineoplastic drug. 2. Technical background:

[0002] Honeysuckle is rich in chlorogenic acid and oleanolic acid saponins. Chlorogenic acid has the functions of antibacterial, anti-virus, increasing white blood cells, protecting liver and gallbladder, anti-tumor, lowering blood pressure, lowering blood fat, scavenging free radicals and stimulating the central nervous system; in recent years, reports have shown that chlorogenic acid has a strong inhibitory matrix Activity of metalloproteinase-9 (MMP-9) (Un-Ho, J., et al. Life Sciences, 2005, ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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