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Use of histamine H4 antagonist for the treatment of post-operative adhesions

一种受体拮抗剂、组胺的技术，应用在使用组胺H4拮抗剂治疗术后粘连领域

Inactive Publication Date: 2011-05-11
JANSSEN PHARMA NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is worth noting that ischemia through surgical site abrasion was not performed in the model used in this study

Method used

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Examples

Experimental program
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Effect test

example

[0088] Various studies were performed using a lateral wall adhesion model to demonstrate the efficacy of histamine H4 receptor antagonists in reducing or inhibiting adhesion formation after peritoneal surgery.

[0089] Lateral peritoneal model

[0090] animal : Twenty-eight female New Zealand White rabbits, 2.4-2.7 kg, were purchased from Irish Farms and quarantined for at least 2 days before use. Rabbits were housed under a 12:12 light:dark cycle with food and water ad libitum.

[0091] Rabbits were anesthetized by intramuscular injection of a mixture of 55 mg / kg ketamine hydrochloride and 5 mg / kg lonpentine. After sterile surgical preparation, a midline laparotomy was performed. A polyethylene catheter (Clay Adams polyethylene tubing PE-60, inner diameter 0.76mm (0.030″), outer diameter 1.22mm (0.048″)) was introduced into the peritoneal cavity and sutured to the side wall with 5-0 Acheron sutures. For topical administration, an Alzet micro-osmotic pump (10 μl / hour, 2...

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Abstract

The present invention includes methods for the inhibition of post-operative adhesion formation between tissue surfaces in a body cavity having been subjected to a surgical procedure, which methods involve administering a histamine H4 receptor antagonist, systemically, directly to tissue surfaces in the body cavity, or both, and to delivery vehicles and compositions suitable for use for local, non-systemic administration of a drug to the body and directly to tissue within a body cavity having been subjected to a surgical procedure.

Description

technical field [0001] The present invention relates to the use of histamine H4 receptor antagonists to inhibit or prevent the formation of postoperative adhesions between tissue surfaces in body cavities, and to compositions comprising histamine H4 receptor antagonists for administration to the body, thereby inhibiting or preventing Postoperative adhesions. Background technique [0002] Adhesion formation, especially after eg peritoneal, thoracic, and spinal surgery, is a major source of postoperative complications and mortality. For example, appendectomy and gynecologic surgery are the most common surgical procedures involving clinically significant adhesion formation. The most serious complication of intraperitoneal adhesions is ileus. In addition, adhesions are associated with chronic or recurrent pelvic pain and infertility in women, nerve compression and pain in the spine, postoperative complications after thoracic surgery, and loss of hand mobility after reconstruct...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/395C07K16/28
CPCA61K31/497A61K45/06A61L31/16A61L2300/432A61L2300/436A61K31/506A61P41/00A61P43/00A61K2300/00A61K31/4184A61K31/417A61K9/50C07K16/28A61K31/496
Inventor R·L·瑟尔蒙德S·A·沃兹沃斯
Owner JANSSEN PHARMA NV
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