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Prostaglandin based compositions and method of use thereof

A prostaglandin and composition technology, which can be used in pharmaceutical formulations, cosmetic preparations, cosmetic preparations and other directions, and can solve problems such as damage to efficacy and the like

Inactive Publication Date: 2011-06-15
PETER THOMAS ROTH LABS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, many prostaglandin-type compounds are not stable, and this instability can impair their utility

Method used

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  • Prostaglandin based compositions and method of use thereof
  • Prostaglandin based compositions and method of use thereof
  • Prostaglandin based compositions and method of use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0091] Example 1. Pre-blended compositions

[0092]

[0093] List of pre-blended ingredients:

[0094] Cetiol AB (including C12-15 alkyl benzoate) may be present in appropriate amounts (QS).

[0095] Prostaglandin E 2 The content of its derivatives may be in the range of about 0.001% or less to about 15% or more, such as about 0.01% to about 12%, including about 0.1% to about 10%, such as about 1% to about 5%, Including about 4-4.5%.

[0096] The content of SDA 40B (e.g., ethanol) may range from about 0.001% or less to about 15% or more, such as from about 0.01% to about 10%, including from about 0.1% to about 9%, such as from about 1% to about 8% %. The blend can then be mixed in the final formulation, for example at about 0.34%.

[0097] Exemplary methods of preparing premixes:

[0098] 1. In a small container, weigh the prostaglandin type compound of the present invention.

[0099] 2. Add ethanol.

[0100] 3. Add the C12-15 Alkyl Benzoate and mix for 10 minutes, ...

Embodiment 2

[0102] Example 2. Direct Blend Compositions

[0103]

[0104] Direct Blend Ingredients List:

[0105] In certain embodiments, prostaglandin E 2 The content of its derivatives may be in the range of about 0.001% or less to about 15% or more, such as about 0.01% to about 12%, including about 0.1% to about 10%, such as about 1% to about 5%, Including about 4-4.5%. The direct blend can be mixed, eg, at about 0.30%, directly into the final formulation, eg, without prior blending with the C12-15 alkyl benzoate and / or ethanol.

[0106] Exemplary methods of preparing premixes:

[0107] 1. In a small container, weigh the prostaglandin type compound of the present invention.

[0108] 2. Add directly to eyelash shine improving composition.

Embodiment 3

[0109] Example 3. Eyelash Shine Improvement Composition

[0110]

[0111]

[0112] Exemplary methods of making eyelash shine improving compositions:

[0113] 1. Add Phase B to a small container.

[0114] 2. Add phase C.

[0115] 3. Add phase A and mix for about 10 minutes, the solution should be clear.

[0116] final recipe

[0117] A-water-appropriate amount

[0118] A-Cavamax-0-5%

[0119] A-Pemulen-0-1%

[0120] A-Panthenol - 0-1%

[0121] A-Ritaloe 200M-0-1%

[0122] B-AMS Leucidal Liquid - 0-2.5%

[0123] C-TEA 99%-0-1%

[0124] D-Liposome ACE-0-1%

[0125] D-Actiglide-0-20%

[0126] D-Lash Premix - 0-5%

[0127] Specifically, fill the mains with water and start propeller mixing. Sift each ingredient of Phase A and mix until completely dispersed. Switch to sweep mixing. Add phase B. Add phase C. And add phase D.

[0128] The final pH of the formulation can be adjusted to be in the range of about pH 5.0-6.5.

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Abstract

The present invention discloses particular prostaglandin based compounds that are relatively more stable in aqueous environments than other such compounds; and further that by complexing such a prostaglandin based compound of the disclosure with an agent, such as cyclodextrin, the prostaglandin based compound may be stabilized and provided in a cosmetic composition that can be used to enhance the appearance of hair.

Description

[0001] Cross References to Related Applications [0002] This application claims under 35 U.S.C. Section 119(e) of U.S. Provisional Application No. 61 / 2008 entitled "Prostaglandin Based Composition and Method of Use Therefore" 127,686, which provisional application is hereby incorporated by reference in its entirety. technical field [0003] The present invention relates to a prostaglandin-type compound, such as prostaglandin, prostamide and / or derivatives or analogs thereof, alone or in combination with stabilizers and / or topical cosmetic vehicles, to improve communication with a subject. Methods and compositions for the appearance of one or more properties related to hair follicles, such as luster, shine, shine, luster, vibrancy, shine, patina, length, thickness, density, or overall appearance of hair. Background technique [0004] Prostaglandin-type compounds, such as prostaglandins, prostamides, and derivatives and analogs thereof, have been reported to be useful in imp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/365A61Q5/00
CPCA61Q5/00A61Q1/10A61K8/42A61K8/365
Inventor 彼得·托马斯·罗思B·布莱克
Owner PETER THOMAS ROTH LABS