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Eye drops containing vitamin E derivatives and preparation method thereof

A technology of eye drops and derivatives, applied in the field of medicine, can solve the problems of inability to achieve therapeutic effect, low local concentration, low bioavailability, etc., and achieve unique antioxidant effect and increase the effect of action time.

Active Publication Date: 2011-06-22
广州智园生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This type of eye drops is often quickly drained on the eye surface, and is blocked by the tear film, cornea, and conjunctival epithelial barrier at the same time, resulting in short drug absorption time, low local concentration, low bioavailability, and short duration of effect. The therapeutic effect of

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Weigh 0.01g of polyethylene glycol 1000 vitamin E succinate and dissolve it in 50ml of water for injection at 90°C, cool to room temperature for later use; weigh 0.1g of sodium hyaluronate and dissolve it in 100ml of water for injection at 80°C, cool to room temperature for later use Weigh 0.1 g of phosphoric acid-phosphate buffer reagent and 5.8 g of sodium chloride and dissolve it in 700 ml of water for injection, add cooled polyethylene glycol 1000 vitamin E succinate solution and sodium hyaluronate solution, add water for injection Set the volume to 1000ml, adjust the pH to 6.5-7.4, and sterilize with high-pressure steam to obtain the eye drops of the present invention.

Embodiment 2

[0027] Weigh 0.1g of polyethylene glycol 1000 vitamin E succinate and dissolve it in 50ml of water for injection at 80°C, cool to room temperature for later use; weigh 0.2g of sodium hyaluronate and dissolve it in 100ml of water for injection at 80°C, cool to room temperature for later use Take by weighing 5 grams of phosphoric acid-phosphate buffer reagent and 6.5 grams of potassium chloride and dissolve in 700ml water for injection, add cooled polyethylene glycol 1000 vitamin E succinate solution and sodium hyaluronate solution, add water for injection Set the volume to 1000ml, adjust the pH to 6.5-7.4, and sterilize with high-pressure steam to obtain the eye drops of the present invention.

Embodiment 3

[0029] Weigh 0.2 g of polyethylene glycol 1000 vitamin E succinate and dissolve it in 100 ml of water for injection at 85°C, cool to room temperature for later use; weigh 0.5 g of hydroxypropyl methylcellulose and dissolve it in 100 ml of water for injection at 4°C; weigh Phosphate-phosphate buffered reagent 6 g and sodium chloride 5.8 g were dissolved in 700 ml of water for injection, added cooled polyethylene glycol 1000 vitamin E succinate solution and hydroxypropyl methylcellulose solution, added water for injection Make up to 1000ml, adjust the pH to 6.5-7.4, filter and sterilize with a 0.2 μm filter membrane to obtain the eye drops of the present invention.

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PUM

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Abstract

The invention discloses eye drops containing vitamin E derivatives and a preparation method thereof. The eye drops comprise main components of water soluble vitamin E derivatives, a thickening agent, a pH regulator, an isotonic agent and water for injection. The eye drops are mainly used for treating dry eye syndrome, and active pharmacological components can be added according to the need and are used for adjuvant treatment of cataract, retinopathy, macular degeneration, keratitis, conjunctivitis and other various ocular diseases. The eye drops have good effects of moisturizing and lubricating, have antioxidation function, can inhibit lipid peroxide reactions in eyes, have effects of expanding peripheral blood vessels, improving blood circulation, protecting, and accelerating injuries to heal, and have good curative effects on various ocular diseases.

Description

technical field [0001] The invention belongs to the technical field of medicines. The invention relates to an eye drop and a preparation method thereof, in particular to an eye drop containing a vitamin E derivative and a preparation method thereof. The eye drops of the present invention are mainly used for the treatment of dry eye, and can also be used as an auxiliary treatment for various ophthalmic diseases such as cataract, retinopathy, macular degeneration, keratitis and conjunctivitis. Background technique [0002] Eye diseases mainly include dry eye, cataract, glaucoma, ocular infectious inflammation, macular degeneration, retinopathy and other diseases. Among them, dry eye syndrome refers to a class of diseases that cause symptoms such as eye discomfort due to tear film instability and ocular surface damage caused by abnormal tear quality or quantity, or abnormal tear dynamics. Environmental pollution, wearing contact lenses, unhygienic eye use, taking certain medi...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/355A61K45/06A61P9/10A61P27/02A61P27/12
Inventor 魏坤凌友张婕
Owner 广州智园生物科技有限公司
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