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Ophthalmic composition for silicone hydrogel contact lenses

A technology for hydrogel contact lenses and contact lenses is applied in the field of inhibiting the adsorption of chlorobutanol on silicone hydrogel contact lenses, and inhibiting the adhesion of bacteria on silicone hydrogel contact lenses, which can solve problems that are not fully understood and easy to use. Adsorption, inability to guess the impact and other problems, to achieve the effect of preventing residues and safe application

Inactive Publication Date: 2011-07-13
ROHTO PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

It is also known that chlorobutanol is very easily adsorbed to conventional soft contact lenses (Patent Document 1)
[0006] However, to date, the effects of chlorobutanol on silicone hydrogel contact lenses have not been fully understood
Moreover, the current situation is that it is completely impossible to predict the effect of using chlorobutanol in combination with other specific ingredients on silicone hydrogel contact lenses

Method used

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  • Ophthalmic composition for silicone hydrogel contact lenses
  • Ophthalmic composition for silicone hydrogel contact lenses
  • Ophthalmic composition for silicone hydrogel contact lenses

Examples

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Embodiment

[0147] Hereinafter, although an Example demonstrates this invention in detail, this invention is not limited to these Examples.

[0148] Reference Test Example 1: Comparison of Adsorption and Residual Amounts of Chlorobutanol on Various SCLs Evaluation

[0149] Using the five types of soft contact lenses shown in Table 1, the amount of chlorobutanol adsorbed on the soft contact lenses and the amount of chlorobutanol remaining after the elution treatment with physiological saline were evaluated.

[0150] First, wash each soft contact lens with physiological saline to wipe off the liquid. Next, as a sample group, each soft contact lens was immersed in 10 mL of the chlorobutanol-containing test solution (Comparative Example 1) shown in Table 2, and shaken at 120 rpm and 34° C. for 24 hours. In addition, as a blank group, all the soft contact lenses were not dipped, and the test solution was shaken under the same conditions as the sample group. Next, the chlorobutanol contai...

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Abstract

The invention provides an ophthalmic composition for SHCL (silicone hydrogel contact lenses), comprising (A) chloretone, and (B) at least one substance selecting from hyaluronic acid, chondroitin sulfate, alginic acid, hydroxypropyl methylcellulose, and a group consisting of salt composition of the above substances in (B). The ophthalmic composition for the silicone hydrogel contact lenses comprises chloretone, can prevent chloretone from remaining and accumulating on SHCL, and can be suitably and safely applied in SHCL.

Description

Technical field [0001] The present invention relates to an ophthalmic composition for silicone hydrogel contact lenses, which contains chlorobutanol. At the same time, even if it is applied to a silicone hydrogel contact lens, it can inhibit the adsorption of chlorobutanol on the lens, and even if the chlorobutanol is Once alcohol is adsorbed on the silicone hydrogel contact lens, it can be easily dissolved by dissolution treatment with physiological saline or the like, making it safe to use. In addition, the present invention relates to a method for inhibiting the adsorption of chlorobutanol on silicone hydrogel contact lenses. Furthermore, the present invention relates to a method for inhibiting bacterial adhesion on silicone hydrogel contact lenses. Background technique [0002] In recent years, the number of wearers of contact lenses (CL) has been increasing, and the number of wearers of soft contact lenses (SCL) is increasing. Generally, when wearing soft contact lens...

Claims

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Application Information

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IPC IPC(8): A61K31/4415A61K31/4174A61K31/4166A61K31/045A61K47/36A61K47/38A61K9/00A61P27/02
Inventor 中田温子
Owner ROHTO PHARM CO LTD
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