Chimeric virus of complete structural protein of hepatitis C virus and GB virus B

A hepatitis C virus, structural protein technology, applied in the direction of virus/bacteriophage, biochemical equipment and methods, applications, etc. Status, inability to indicate HCV-host interaction, etc.
CN102154227AActive Publication Date: 2011-08-17SOUTHERN MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
SOUTHERN MEDICAL UNIVERSITY
Publication Date
2011-08-17

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Abstract

The invention relates to a virus, a composition and the field of preparation or purification thereof, in particular to a chimeric virus of the complete structural protein of a hepatitis C virus and a GB virus B. The chimeric virus is formed by connecting the sequence of a non-coding region on the 5' terminal of the GB virus B, the gene sequence of the complete structural protein of the hepatitis C virus, a nonstructural protein of the GB virus B and the sequence of a non-coding region on a 3' terminal in turn, wherein the gene sequence of the complete structural protein of the hepatitis C virus is the gene sequence of the complete structural protein of 1b genotype hepatitis C virus. The chimeric virus can be used to infect marmoset effectively through the intrahepatic or intravenous injection of the chimeric virus-containing serum of a primary marmoset. The chimeric virus simulates the infection and immune state of the hepatitis C virus in bodies of primates, a platform for testing and evaluating the immunity to the complete structural protein of the hepatitis C virus is provided, and the scientific problems such as limitation on the research on immunity, prevention and control ofhepatitis C virus and vaccine evaluation due to lack of small infected models of primates are solved.
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Description

technical field

[0001] The present invention relates to the field of virus, composition and its preparation or purification, in particular to the field of virus modified by introducing foreign gene material. Background technique

[0002] At present, there are about 170 million people infected with hepatitis C virus (Hepatitis C Virus, HCV) worldwide. Hepatitis C virus is one of the main pathogenic factors of acute / chronic hepatitis transmitted by blood. The prevalence of HCV infection varies greatly around the world, especially in developing countries. 50-85% of hepatitis C virus infected patients develop into chronic hepatitis, 10-20% of them further develop into complex chronic liver diseases such as liver cirrhosis, and 1-5% develop into liver cancer after 20 or 30 years. However, there is still a lack of very effective therapeutic drugs for hepatitis C virus infection at present, and what is more serious is that there is no hepatitis C preventive vaccine in the world so...

Claims

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