Decoquinate gel microsphere and its preparation method

A technology of decoquinate and gel microspheres, which is applied in the direction of inorganic non-active ingredients, anti-infective drugs, block delivery, etc., can solve the problem that the anticoccidial effect of decoquinate cannot be fully exerted, and the particle size cannot reach Requirements, low utilization rate and other issues, to achieve good market prospects, improve stability, the effect of simple preparation process

Inactive Publication Date: 2011-11-02
HENAN SOAR VETERINARY PHARMA
1 Cites 3 Cited by

AI-Extracted Technical Summary

Problems solved by technology

Because decoquinate is insoluble in water, the utilization rate is low and the use is wasteful
And studies have shown that as the particle size of decoquinate decreases, its anti-coccidial effect is...
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Abstract

The invention belongs to the technical field of feed additives, particularly to a decoquinate gel microsphere and its preparation method. The particle diameter of the gel microsphere is 1 - 5 mm. According to the invention, the microsphere is capable of increasing the stability of decoquinate, which has the advantages of good slow-release performance, simple preparation process, easy large-scale production and good market prospects.

Application Domain

Inorganic non-active ingredientsAntiparasitic agents +2

Technology Topic

DecoquinateMicrosphere +3

Image

  • Decoquinate gel microsphere and its preparation method

Examples

  • Experimental program(5)
  • Effect test(1)

Example Embodiment

[0022] Example 1
[0023] Weigh 1.1g CaCl 2 , Add distilled water to dissolve, dilute to 100ml, get CaCl 2 Aqueous solution. Take another 5g of decoquinate and 1g of sodium alginate, mix, add 194ml of distilled water, stir to make it fully mixed, drop (dropping rate of 100 drops/min) above CaCl 2 After stirring and reacting for 10 minutes in an aqueous solution, the formed gel microspheres are taken out, washed with distilled water, and dried to obtain decoquine gel microspheres with a particle size of 3.4 mm.

Example Embodiment

[0024] Example 2
[0025] Weigh 8.3g CaCl 2 , Add distilled water to dissolve, dilute to 500ml, get CaCl 2 Aqueous solution. Take another 1g of decoquinate and 5g of sodium alginate, mix, add 494ml of distilled water, stir to make it fully mixed, drop (dropping rate of 60 drops/min) above CaCl 2 After stirring and reacting for 24 hours in the aqueous solution, the formed gel microspheres were taken out, washed with distilled water, and dried to obtain decoquine gel microspheres with a particle size of 3.6 mm.

Example Embodiment

[0026] Example 3
[0027] Weigh 4.4g CaCl 2 , Add distilled water to dissolve, dilute to 200ml, get CaCl 2 Aqueous solution. Add another 3g of sodium alginate to 200ml of distilled water to obtain a 1.5% sodium alginate solution. Weigh 6g of decoquinate and add it to the above sodium alginate solution, stir to make it fully mixed; then the mixture is mixed under stirring conditions Add CaCl at a rate of 10 drops/min 2 In the aqueous solution, after 72 hours of reaction, the formed gel microspheres were taken out, washed with distilled water, and dried to obtain decoquinate gel microspheres with a particle size of 4.1 mm.

PUM

PropertyMeasurementUnit
Particle size1.0 ~ 5.0mm
Particle size3.4mm

Description & Claims & Application Information

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Classification and recommendation of technical efficacy words

  • Improve stability
  • Easy to prepare
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