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Decoquinate gel microsphere and its preparation method

A technology of decoquinate and gel microspheres, which is applied in the direction of inorganic non-active ingredients, anti-infective drugs, block delivery, etc., can solve the problem that the anticoccidial effect of decoquinate cannot be fully exerted, and the particle size cannot reach Requirements, low utilization rate and other issues, to achieve good market prospects, improve stability, the effect of simple preparation process

Inactive Publication Date: 2011-11-02
HENAN SOAR VETERINARY PHARMA
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  • Summary
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  • Claims
  • Application Information

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Problems solved by technology

Because decoquinate is insoluble in water, the utilization rate is low and the use is wasteful
And studies have shown that as the particle size of decoquinate decreases, its anti-coccidial effect is stronger, but most of the particle sizes of the existing premixes in my country cannot meet the requirements, and the anti-coccidial effect of decoquinate cannot be fully utilized. Coccidian effect

Method used

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  • Decoquinate gel microsphere and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Weigh 1.1g CaCl 2 , add distilled water to dissolve, and set the volume to 100ml to obtain CaCl 2 aqueous solution. Take another 5g of decoquinate and 1g of sodium alginate, mix, add 194ml of distilled water, stir, make it fully mixed, drop in (dropping speed is 100 drops / min) the above CaCl 2 In the aqueous solution, stirred and reacted for 10 minutes, the formed gel microspheres were taken out, rinsed with distilled water, and dried to obtain decoquinate gel microspheres with a particle size of 3.4 mm.

Embodiment 2

[0025] Weigh 8.3g CaCl 2 , add distilled water to dissolve, and set the volume to 500ml to obtain CaCl 2 aqueous solution. Take another 1g of decoquinate and 5g of sodium alginate, mix, add 494ml of distilled water, stir, make it fully mixed, drop (dropping speed is 60 drops / min) the above CaCl 2 In the aqueous solution, stirred, and reacted for 24 hours, the formed gel microspheres were taken out, rinsed with distilled water, and dried to obtain decoquinate gel microspheres with a particle size of 3.6 mm.

Embodiment 3

[0027] Weigh 4.4g CaCl 2 , add distilled water to dissolve, and set the volume to 200ml to obtain CaCl 2 aqueous solution. Take another 3g of sodium alginate and add 200ml of distilled water to obtain a 1.5% sodium alginate solution, weigh 6g of decoquinate and add it to the above-mentioned sodium alginate solution, stir, and make it fully mixed; Add CaCl at a rate of 10 drops / min 2 In the aqueous solution, after reacting for 72 hours, the formed gel microspheres were taken out, rinsed with distilled water, and dried to obtain decoquinate gel microspheres with a particle size of 4.1 mm.

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Abstract

The invention belongs to the technical field of feed additives, particularly to a decoquinate gel microsphere and its preparation method. The particle diameter of the gel microsphere is 1 - 5 mm. According to the invention, the microsphere is capable of increasing the stability of decoquinate, which has the advantages of good slow-release performance, simple preparation process, easy large-scale production and good market prospects.

Description

technical field [0001] The invention belongs to the technical field of feed additives, in particular to a decoquinate gel microsphere and a preparation method thereof. Background technique [0002] Decoquinate (decoquinate) is a very effective quinolone anticoccidiostat for livestock and poultry. It mainly works by inhibiting the development of sporozoites in the early stage and killing early schizonts in the middle stage. The chemical name of Diludine is 2,6-dimethyl-3,5-diethylcarboxylate-1,4-decyloxyquinate, and the molecular formula is C 24 h 35 N0 5 , molecular weight 417.55, very slightly soluble in chloroform or ether, insoluble in water or ethanol; melting point 242-246°C, its chemical structure is as follows: [0003] . [0004] As a new type of coccidial drug, decoquinate has been widely used. Practice has proved that decoquinate has excellent anti-coccidial effect and growth-promoting effect, and is effective against a variety of Eimeria. Because decoquina...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/47A61K47/36A61K47/02A61P33/02
Inventor 李凌峰胡帅李玮君
Owner HENAN SOAR VETERINARY PHARMA
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