Biodegradable filling for restoration of alveolar bone

A bone repair and decomposing technology, applied in medical science, dentistry, dental preparations, etc., can solve problems such as alveolar bone cannot be restored, teeth are skewed, and cannot grow enough

Active Publication Date: 2013-05-29
SUNMAX BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, in such a short period of time, the bone cells in the patient's alveolar cannot grow enough bone tissue, so that the new alveolar bone cannot return to its original integrity, and because the new alveolar bone tissue does not need support around it. Tooth, so these tissues will be absorbed by the patient's body over time, which is the so-called alveolar bone atrophy, which will exacerbate the lack of height or width of the alveolar bone, which may cause the normal teeth around the missing tooth to be skewed

Method used

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  • Biodegradable filling for restoration of alveolar bone
  • Biodegradable filling for restoration of alveolar bone
  • Biodegradable filling for restoration of alveolar bone

Examples

Experimental program
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Effect test

preparation example Construction

[0046] Preparation of cross-linked collagen fiber

[0047] Take the concentration of 3.0±0.5mg / mL Atelocollagen and add 0.2M phosphate buffer solution, adjust the pH to 7.0±0.2, continue stirring for 4 hours, add the final concentration of 0.003% glutaraldehyde, Or use 1-ethyl-3-(dimethylaminopropyl)carbodiimide (EDC) with a final concentration of 0.004% and N-hydroxysuccinimide (NHS) with a final concentration of 0.0016% as cross-linking And adjust the pH to 5.5±0.2, control the temperature at 35±5℃ and continue to stir for 16 hours to carry out the chemical crosslinking reaction.

[0048] After the chemical cross-linking reaction, the cross-linked collagen fibers are reduced by a homogenizer. After homogenizing at 10000 ± 200 rpm for 10 ± 2 minutes, the cross-linked collagen fibers are collected by centrifugation at 14000 G for 1 hour. The concentration of the resulting cross-linked collagen fibers is generally in the range of 65.0 to 100.0 mg / ml.

[0049] The cross-linked collag...

Embodiment 1

[0056] Biphasic phosphate is used as supporting particles, in which tricalcium phosphate (β-TCP) with a particle size of 0.5 to 2.0 mm and hydroxylapatite (HAP) with a particle size of 0.075 to 0.150 mm are used to 60%:40% by weight ratio is mixed.

[0057] Take the 30±0.2mg / mL cross-linked collagen fiber slurry prepared above, and mix the above-mentioned HAP / β-TCP complex into the cross-linked collagen fiber slurry, wherein the cross-linked collagen fiber slurry: HAP The / β-TCP complex is mixed in a weight ratio of 30%:70%.

[0058] For the molding method of the biodegradable filling material for alveolar bone repair in this embodiment, please refer to Figure 1A to 1C . First, like Figure 1A As shown, a forming mold 10 is prepared, which has a forming groove 101. The inner diameter of the forming groove 101 is gradually reduced from the opening to the inside like a horn, and its bottom is arc-shaped, so that the subsequently manufactured fillings are formed as a whole Dome cone...

Embodiment 4

[0068] HAP / β-TCP composite and bioactive glass are used as supporting particles, among which tricalcium phosphate (β-TCP) / hydroxyapatite (HAP) with particle size ranging from 0.5 to 1.0 mm and particle size are used. In 150 to 600μm bioactive glass.

[0069] Take the 30±0.2mg / mL cross-linked collagen fiber slurry prepared above, and mix the HAP / β-TCP complex and bioactive glass into the cross-linked collagen fiber slurry, wherein the cross-linked collagen fiber Slurry: HAP / β-TCP complex: Bioactive glass is mixed in a weight ratio of 30%: 35%: 35%.

[0070] For the molding method of the biodegradable filling material for alveolar bone repair in this embodiment, please refer to Figure 6A to 6G . First, like Figure 6A As shown, a forming mold 12 is prepared, which has a forming groove 112. The inner diameter of the forming groove 112 is approximately the same from the opening to the inside, but the inner diameter is gradually reduced until the bottom, so that the subsequently manuf...

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Abstract

The invention relates to a biodegradable filling for the restoration of an alveolar bone, comprising first crosslinking type collagen fibers and supporting granules, wherein the first crosslinking type collagen fibers are prepared by reacting a crosslinking agent with non-crosslinked collagen fibers; and the supporting granules are biomedical ceramic granules, bioactive glasses or combinations ofthe biomedical ceramic granules and the bioactive glasses and distributed in the first crosslinking type collagen fibers.

Description

Technical field [0001] The present invention relates to a biodegradable filling material for alveolar bone repairing, in particular to a biodegradable filling material for alveolar bone repairing that delays degradation and has plasticity. Background technique [0002] In the past, when the patient’s teeth were unable to maintain their original functions due to external force fracture, tooth decay, periodontal disease or periapical lesions, the tooth was removed and the cavity and trauma area caused by the tooth extraction were used to stop bleeding with sterile fiber gauze And repair wounds. However, the disadvantage of using fiber gauze is that it can only stop bleeding, is not absorbed by the patient, and is easy to embed food residues, so it is easy to cause wound infection, and it takes longer to repair the wound. [0003] In recent years, collagen dental filling materials have appeared. This type of collagen dental filling materials are only composed of collagen, which can b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K6/033A61K6/027A61K6/02A61K6/838
Inventor 林建兴林育德卢香吟王进富谢达仁
Owner SUNMAX BIOTECH
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