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Application of SB-3CT (2-[(4-phenoxyphenyl) sulfonylmethyl] thiirane) in treating cerebrovascular spasm (CVS)

A technology of cerebral vasospasm and drugs, which is applied in the field of new drug use research, can solve the problems of cerebral vasospasm that have not yet been studied, and achieve the effect of reducing the thickening degree of the spasm blood vessel wall and reducing the degree of stenosis of the lumen

Inactive Publication Date: 2012-11-21
THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no research on the relationship between SB-3CT and cerebral vasospasm in cerebrovascular disease, so the present invention comes from

Method used

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  • Application of SB-3CT (2-[(4-phenoxyphenyl) sulfonylmethyl] thiirane) in treating cerebrovascular spasm (CVS)
  • Application of SB-3CT (2-[(4-phenoxyphenyl) sulfonylmethyl] thiirane) in treating cerebrovascular spasm (CVS)
  • Application of SB-3CT (2-[(4-phenoxyphenyl) sulfonylmethyl] thiirane) in treating cerebrovascular spasm (CVS)

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Experimental program
Comparison scheme
Effect test

Embodiment

[0033] 1. Materials and methods

[0034] 1. Materials

[0035] 1.1 Reagents and experimental equipment

[0036] 1.1.1 Main Drugs and Reagents

[0037] SB-3CT, purchased from Sigma, USA; paraformaldehyde, PBS, DAB chromogen, hematoxylin, eosin, glacial acetic acid (analytical grade), normal saline, distilled water, 10% chloral hydrate. Rabbit Anti-MMP-9 was purchased from Beijing Boaosen Biotechnology Co., Ltd., China.

[0038] 1.1.2 Main instruments

[0039] Paraffin slicer (Leica 3215, Germany), automatic dehydrator (Leica 1020, Germany), paraffin embedding machine (BMJ-III, Changzhou, China), Olympus BX40 optical microscope, image photography software (LOGENE-I Path PRT diagnostic report Workstation), a set of surgical instruments, etc.

[0040] 1.2 Experimental animals

[0041] Adult healthy male SD rats were provided by the Experimental Animal Research Center of Soochow University School of Medicine (Su SYXK2002-2010, clean level: level 2), weighing 250-300 g. Befor...

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Abstract

The invention discloses application of the compound (I) as shown in formula (I) in preparing a pharmaceutical composition for treating cerebrovascular spasm. Animal experiments confirm that: SB-3CT has certain curative effect to CVS after SAH (subarachnoid hemorrhage), and can mitigate the thickening degree of spastic vessel walls and the lumen stenosis, thus providing a new treatment approach for CVS after SAH.

Description

technical field [0001] The invention belongs to the field of new application research of medicines, and in particular relates to an application of SB-3CT in treating cerebral vasospasm. Background technique [0002] Cerebral vasospasm is an important complication of aneurysmal subarachnoid hemorrhage, and an important factor affecting the survival rate and quality of life of patients. Studies have reported that angiography can reveal CVS in 70% of SAH patients, and about 17% to 40% of them have symptoms of cerebral ischemia. The cause and mechanism of CVS after SAH have been studied for decades, but they have not been fully elucidated so far, and the treatment is therefore lack of pertinence. [0003] At present, various calcium ion antagonists such as nimodipine, nicardipine, papaverine, etc. are mainly researched on the contraction of vascular smooth muscle, as well as the treatment of NO agonists for the weakening of vasodilation, including intravenous infusion. Injecti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/38A61P9/00
Inventor 王中陈罡党宝齐
Owner THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
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