A pharmaceutical composition of Panax notoginseng extract and its preparation method
The technology of extract and composition is applied in the field of pharmaceutical composition of Panax notoginseng extract, and achieves the effects of uniform and stable curative effect, convenient use and little irritation.
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preparation Embodiment 1
[0017] Get dry Radix Notoginseng and rhizome 20.0kg, use Chinese herbal medicine pulverizer (purchased from Tianjin Tester Instrument Co., Ltd.) to pulverize, be 40% ethanol solution reflux extraction 3 times with the concentration of 8 times medicinal material weight, each 1.0 hour, Combine the extracts, recover ethanol to the maximum, put the concentrated solution on a D101 macroporous adsorption resin (purchased from Cangzhou Baoen Adsorption Material Technology Co., Ltd.) column, first elute with 6 times the column volume of deionized water, and discard the eluent , then eluted with 5% ethanol solution, controlled the elution end point with thin-layer chromatography, discarded the eluent, and then eluted with 50% ethanol solution of 3 times the column volume, collected the eluent, concentrated under reduced pressure, and dried 2153.6 g of Panax notoginseng saponins extract was obtained (the content of Panax notoginseng total saponins was 90.6%).
[0018] Get 20.0kg of Pana...
preparation Embodiment 2
[0023] Take 20.0 kg of dried Radix Notoginseng, use a Chinese herbal medicine pulverizer (purchased from Tianjin Test Instrument Co., Ltd.) to pulverize, and use a concentration of 6 times the weight of medicinal materials to reflux extract 60% ethanol solution for 3 times, each time for 1.5 hours, and combine the extractions solution, recover ethanol to the end, put the concentrated solution on AB-8 macroporous adsorption resin (purchased from Cangzhou Baoen Adsorption Material Technology Co., Ltd.) column, first elute with 8 times the column volume of deionized water, and discard the eluent , then eluted with 10% ethanol solution, controlled the elution end point with thin-layer chromatography, discarded the eluent, and then eluted with 30% ethanol solution of 5 times the column volume, collected the eluate, concentrated under reduced pressure, and dried Get 2009.2g of Panax notoginseng total saponins extract (the Panax notoginseng total saponins content is 89.4%);
[0024] ...
preparation Embodiment 3
[0026] Take 20.0 kg of dried Panax notoginseng roots, use a Chinese herbal medicine pulverizer (purchased from Tianjin Test Instrument Co., Ltd.) to pulverize, and use 4 times the concentration of the medicinal material to reflux extract 2 times with an 80% ethanol solution, each time for 2.0 hours, and combine Extract the solution, recover the ethanol to the maximum, put the HPD-100 macroporous adsorption resin (purchased from Cangzhou Baoen Adsorption Material Technology Co., Ltd.) column on the concentrated solution, first elute with 6 times the column volume of deionized water, and discard the eluted solution. solution, and then eluted with 15% ethanol solution, and the elution end point was controlled by thin-layer chromatography. The eluent was discarded, and then eluted with 7 times column volume of 80% ethanol solution. 2108.3 g of Panax notoginseng saponins extract was obtained (the content of Panax notoginseng total saponins was 88.1%).
[0027] Get 20.0kg of dried R...
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