Preparation technology and purpose of citrus grandis peel flavones

A technology for flavonoids from grapefruit peel and a preparation process is applied in the field of preparation technology of flavonoids from grapefruit peel to achieve the effects of enhancing cardiovascular function, reducing blood lipids and improving utilization rate

Inactive Publication Date: 2012-01-04
ZHEJIANG CHINESE MEDICAL UNIVERSITY
View PDF0 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no literature report on whether citrus flavonoids (Pure Total Flavonoids Citrus, PTFC) can

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation technology and purpose of citrus grandis peel flavones
  • Preparation technology and purpose of citrus grandis peel flavones
  • Preparation technology and purpose of citrus grandis peel flavones

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0059] Example 1

[0060] The preparation process of Huyou peel flavone, the preparation process includes the following steps:

[0061] (1) Pre-treatment: sorting and washing the huyou, and then separating the peel and pulp of the washed huyou, and take the fresh ripe peel and cut it into silk, set aside;

[0062] (2) Extraction: Precisely weigh 500g of Huyou peel shreds, add 6 times ethanol solution to the peel, soak for 0.5 hours, heat to boiling, extract 2 times, each extraction interval is 30min to obtain the extract, the ethanol The mass concentration is 25%;

[0063] (3) Concentration: the extract is concentrated under vacuum and reduced pressure at a temperature of 40°C and a vacuum of -0.08Mpa, and concentrated to 40% of the original volume of the concentrated solution. Add 92% ethanol to the concentrated solution and stand still Primary alcohol precipitation for 12 hours, the volume ratio of concentrated solution and ethanol is 1:2, take the supernatant of primary alcohol pr...

Example Embodiment

[0068] Example 2

[0069] The preparation process of Huyou peel flavone, the preparation process includes the following steps:

[0070] (1) Pre-treatment: sorting and washing the huyou, and then separating the peel and pulp of the washed huyou, and take the fresh ripe peel and cut it into silk, set aside;

[0071] (2) Extraction: accurately weigh 500g of Huyou peel shreds, add 10 times ethanol solution to the peel, soak for 1.5 hours, heat to boiling, extract 3 times, each extraction interval is 30min to obtain the extract, the ethanol The mass concentration is 50%;

[0072] (3) Concentration: The extract is concentrated under reduced pressure at a temperature of 50°C and a vacuum of -0.06Mpa, and concentrated to 50% of the original volume to obtain a concentrated solution. Add edible ethanol with a mass concentration of 94% to the concentrated solution and leave it still. Leave the primary alcohol precipitation for 16 hours, the volume ratio of the concentrated solution to the edibl...

Example Embodiment

[0079] Example 3

[0080] The preparation process of Huyou peel flavone, the preparation process includes the following steps:

[0081] (1) Pre-treatment: sorting and washing the huyou, and then separating the peel and pulp of the washed huyou, and take the fresh and ripe peel for later use;

[0082] (2) Extraction: accurately weigh 500g of Huyou peel shreds, add 16 times the ethanol solution to the peel, soak for 3 hours, heat to boiling, extract 3 times, each extraction interval is 48min to obtain the extract, the ethanol The mass concentration is 60%;

[0083] (3) Concentration: The extract is concentrated under vacuum and reduced pressure at a temperature of 55°C and a vacuum of -0.08Mpa, and concentrated to 50% of the original volume to obtain a concentrated solution. Add ethanol with a mass concentration of 96% to the concentrated solution and leave it to stand. Preliminary alcohol precipitation for 20 hours, the volume ratio of concentrate to ethanol is 1:4, take the supernata...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Weightaaaaaaaaaa
Login to view more

Abstract

The invention belongs to the technical field of the preparation of active substances in traditional Chinese medicines, and especially relates to a preparation technology and a purpose of citrus grandis peel flavones. The preparation technology comprises steps of (1) pre-treating, wherein peels of fresh ripe fruits are cut into strips for later use; (2) extracting, wherein an ethanol solution is added to the citrus grandis peel strips, the peels are dipped, heated until boiled, and an extract is obtained; (3) condensing, wherein the extract is condensed until a total flavonoid content is higher than 38.33mg/mL, and the condensate is obtained; (4) separating and purifying; and (5) drying. The invention is advantaged in that: the preparation technology of citrus grandis peel flavones provided by the invention is stable and applicable; the flavones content of the product is higher than that obtained with prior technologies; the utilization rate of the raw materials is improved, and the extraction rate of effective components is improved; the citrus grandis peel flavones can be used for treating hyperlipidemia, reducing blood fat, treating cardiovascular diseases and enhancing cardiovascular functions.

Description

technical field [0001] The invention belongs to the technical field of preparation technology of active substances of traditional Chinese medicines, and in particular relates to a preparation technology of citrus peel flavone and its application. Background technique [0002] Changshan Huyou (Citrus changshan-huyou Y.B chang), also known as Huyou and Jinyu, is a hybrid of pomelo [C. grandis (Linn.) osbeek] and sweet orange [C. sinensis (Linn.) osbeek]. Changshan, Zhejiang is the key production area. Its skin is collected in late autumn and early winter, divided into 5-7 petals, hung up to dry in the sun or shade, and used as medicinal materials. It is warm in nature, sweet and bitter in taste, and non-toxic, and it is recorded in "Tang Materia Medica", "Materia Medica Qiuyuan", "Liezi", "Compendium" and other documents. Its functions and indications are: resolving phlegm, eliminating indigestion, lowering qi, and quick diaphragm; treating qi depression, chest tightness, co...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K36/752A23L1/29A61P3/06A61P9/10A61K131/00A23L33/00
Inventor 熊耀康蒋剑平张春椿徐春根
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap