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Bladder cancer patient urine specific metabolite spectrum, establishing method and application

A bladder cancer and application technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of invasiveness, and achieve the effect of high specificity, good application prospects, and low cost

Active Publication Date: 2014-12-10
BGI GENOMICS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Aiming at the shortcomings of existing bladder cancer diagnosis methods such as traumaticity and invasiveness, the problem to be solved by the present invention is to provide a metabolomics technology to provide a basis for the early diagnosis of bladder cancer. The method has high sensitivity, good specificity, and non-invasive Etc

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  • Bladder cancer patient urine specific metabolite spectrum, establishing method and application
  • Bladder cancer patient urine specific metabolite spectrum, establishing method and application
  • Bladder cancer patient urine specific metabolite spectrum, establishing method and application

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Embodiment Construction

[0017] Embodiments of the present invention will be described in detail below in conjunction with examples, but those skilled in the art will understand that the following examples are only used to illustrate the present invention, and should not be considered as limiting the scope of the present invention.

[0018] One aspect of the present invention provides a method for establishing a subject's urine metabolite profile, comprising the following steps:

[0019] (1) Collection and processing of samples: collect urine samples from subjects, and remove macromolecules such as proteins after processing;

[0020] (2) Analysis and determination by liquid chromatography-mass spectrometry: the metabolite profile in urine is obtained by means of liquid chromatography and mass spectrometry, and the metabolic profile is analyzed.

[0021] Another aspect of the present invention provides a method for establishing urine-specific metabolite profiles of patients with bladder cancer, compris...

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Abstract

The invention provides a bladder cancer patient urine specific metabolite spectrum, an establishing method and an application, and especially provides a method for establishing a spectrum of specific metabolites in urine of bladder cancer patients, and a method for screening a related specific biomarker. Through metabonomics, especially metabonomics based on liquid chromatography-mass spectrometry combined technology, the invention establishes a bladder cancer patient urine specific metabolite spectrum. The invention provides a basis for early diagnosis of bladder cancer and bladder cancer diseases with different pathological stages, and also provides a spectrum of specific metabolites in urine of bladder cancer patients and a related specific biomarker. The method provided by the invention has the characteristics of noninvasiveness, convenience, and rapidness, can accurately reflect the difference of metabolite spectra of bladder cancer patients and normal people, and has high specificity.

Description

technical field [0001] The present invention relates to cancer, especially bladder cancer. The present invention also relates to metabolomics, especially metabolomics based on liquid chromatography mass spectrometry analysis technology. The invention provides a basis for early diagnosis of bladder cancer and bladder cancer diseases of different pathological stages, and provides specific metabolite profiles and related specific biomarkers in urine of bladder cancer patients. And the present invention also provides a method for establishing a specific metabolite profile in urine of bladder cancer patients and screening related specific biomarkers. Background technique [0002] Bladder cancer is one of the most common clinical tumors, and the incidence of bladder cancer ranks ninth among malignant tumors in the world [1]. Bladder cancer can occur at any age, even in children, but the main age of onset is after middle age, and its incidence increases with age. In my country, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06
Inventor 成军栾合密黄颖瑜
Owner BGI GENOMICS CO LTD
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