Curcuma zedoary oil extract, preparation method thereof and purpose thereof

A technique for warm curcuma seed oil and extract, which is applied to the field of curcuma curcuma oil extract and its preparation and use, can solve the problems of unstable quality, insufficient heat source, difficult stratification, etc., achieves remarkable effect, improves extraction rate and quality stable effect

Active Publication Date: 2012-02-29
HAINAN BIKAI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, since warm curcuma contains more starch grains, it is easy to be evaporated together with water vapor and volatile oil during the long-term heating and distillation process, resulting in a large amount of foam in the extracted volatile

Method used

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  • Curcuma zedoary oil extract, preparation method thereof and purpose thereof
  • Curcuma zedoary oil extract, preparation method thereof and purpose thereof
  • Curcuma zedoary oil extract, preparation method thereof and purpose thereof

Examples

Experimental program
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Effect test

preparation example 1

[0013] Take 1.5 kg of warm curcuma medicinal material, grind it into 20-40 mesh fine powder, and put it into an extraction kettle (HA221-50-06 supercritical CO produced by Jiangsu Nantong Huaan Supercritical Extraction Co., Ltd. 2 In the extraction device), the selection extraction pressure is 18Mpa, and the extraction temperature is 55°C; the separation kettle I pressure is 12Mpa, and the temperature is 55°C; the separation kettle II pressure is 7Mpa, and the temperature is 45°C; 2 The flow rate is 80-100kg / h, the extraction time is 2h, 210g of oil is obtained, and the extraction rate is 14.0%. Separation and analysis by high-performance liquid chromatography (see detection method 2 for analysis conditions: select HPLC method to qualitatively and quantitatively analyze active ingredients and related substances in zedoary oil), the test results are: the content of furandiene is 31.3%, and the content of gemmaketone (牻 Geranone) content is 15.5%, and curcumadione content is 11.7...

preparation example 2

[0015] Take 1.5 kg of warm curcuma medicinal material, grind it into a fine powder of 20-40 meshes, and put it into a supercritical extraction apparatus (model HA221-50-06 supercritical CO produced by Jiangsu Nantong Huaan Supercritical Extraction Co., Ltd. 2 Extraction device), choose 17Mpa as supercritical CO 2 The extraction pressure of extracting zedoary oil is 50°C; the pressure of separation kettle I is 10Mpa, and the temperature is 50°C; the pressure of separation kettle II is 7.5Mpa, and the temperature is 60°C; 2 Flow rate is 25kg / h, extracts 2.5h, obtains zedoary oil 198g, and extraction rate reaches 13.2%, and wherein the content of furandiene in warm zedoary oil is 33.8%, and the content of germanone (geranone) is 14.1%, Curcumadione content is 12.6%.

preparation example 3

[0017] Take 1.5 kg of warm curcuma medicinal material, grind it into a fine powder of 20-40 meshes, and put it into a supercritical extraction apparatus (model HA221-50-06 supercritical CO produced by Jiangsu Nantong Huaan Supercritical Extraction Co., Ltd. 2 Extraction device), choose 15Mpa as supercritical CO 2 The extraction pressure of extracting turmeric oil is 55°C; the pressure of the separation tank I is 12Mpa, and the temperature is 50°C; the pressure of the separation tank II is 8Mpa, and the temperature is 63°C; 2 Flow rate is 25kg / h, extracts 2.5h, obtains zedoary oil 191g, and extraction rate reaches 12.7%, and wherein the content of furandiene in warm zedoary oil is 30.4%, and the content of germanone (geranone) is 15.1%, Curcumadione content is 12.7%.

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Abstract

The invention relates to a Curcuma zedoary oil extract, a preparation method thereof, a detection method thereof, and a purpose thereof, and concretely relates to a CO2 supercritical extraction method for preparing the Curcuma zedoary oil extract. The Curcuma zedoary oil provided by the invention has the advantages of stable and controllable quality, no irritation, no Curzerene containing, extraction completeness of effective components, and simple preparation. The invention provides the purpose of the Curcuma zedoary oil in the preparation of anticancer medicines.

Description

technical field [0001] The present invention relates to traditional Chinese medicine warm zedoary oil extract and its preparation method and application, in particular to a kind of warm zedoary oil extract containing sesquiterpene components and its application in preparing medicine for treating cancer. Background technique [0002] Curcuma wenyujin is the dry rhizome of Curcuma wenyujin Y.H.Chen et C.Ling, a plant of the Zingiberaceae family, commonly known as "Ezhu warmer". The warmed curcuma medicinal material, warmed curcuma oil and warmed curcuma oil injection are listed in the Chinese Pharmacopoeia, and the warmed curcuma oil is a clinically proven antiviral and anticancer drug (Chinese Pharmacopoeia 2005 edition). The warm zedoary oil recorded in the Chinese Pharmacopoeia has always been extracted by steam distillation. Due to the long heating time and high heating temperature of the traditional production process, the obtained zedoary oil contains many impurities, es...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P35/00
Inventor 孙秀燕
Owner HAINAN BIKAI PHARM CO LTD
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