Preparation method of common turnip extract

A technology of extracts and coriander root, applied in the field of medicine, can solve the problems such as the anti-hypoxia application that has not yet been seen, and achieve the effects of improving hypoxia tolerance, promoting anti-oxidative damage, and promoting utilization.

Inactive Publication Date: 2012-04-18
西藏缘苍工贸有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

1) Only experiments have shown that total flavonoids have anti-tumor effects! There is no test to show that the total flavonoids extract of coriander root has anti-hypoxia effect! Amo

Method used

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  • Preparation method of common turnip extract
  • Preparation method of common turnip extract
  • Preparation method of common turnip extract

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Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0012] Specific embodiment one: this specific embodiment adopts the following technical scheme: its preparation method is: 1.60% alcohol extraction: take the dry Radix Coriander root, pulverize with pulverizer, be 1: 3 volume ratio with Radix Radix Radix Radix Radix Radix: ethanol Add 65% ethanol, stir at 100°C for 8 hours, filter with suction, discard the residue, and obtain the filtrate. Repeat 3 times. 2. Water extraction of residue after 60% alcohol extraction: dry the residue after 60% alcohol extraction, add high water with residue:ethanol at a volume ratio of 1:10, and boil. Boil under boiling water for 6 hours, filter with suction, discard the precipitate, and obtain the filtrate. Repeat 2 times. 3. Evaporating and concentrating the combined filtrates: combining three times of 60% alcohol-extracted filtrates and two times of water-extracted filtrates, and concentrating and drying the filtrates to obtain the Radix Coriander root extract.

specific Embodiment approach 2

[0013] Specific embodiment two: 1, 60% alcohol extraction: take the dry coriander root, pulverize with pulverizer, add 65% ethanol with coriander root: ethanol as 1: 10 volume ratio, stir 2 hours at 60 ℃, suction filtration , discard the residue to obtain the filtrate. Repeat 5 times. 2. Water extraction of residue after 60% alcohol extraction: dry the residue after 60% alcohol extraction, add high water with residue:ethanol at a volume ratio of 1:2, and boil. Boil under boiling water for 2 hours, filter with suction, discard the precipitate, and obtain the filtrate. Repeat 2 times. 3. Evaporating and concentrating the combined filtrates: combining five 60% alcohol-extracted filtrates and two water-extracted filtrates, and concentrating and drying the filtrates to obtain the Radix Coriander root extract.

Embodiment 1

[0014] Embodiment 1: Tolerance test of normal pressure and hypoxia in mice

[0015] experimental method:

[0016] 100 Kunming male mice, weighing (20±2) g, were randomly divided into 5 groups. The negative control group was administered with distilled water at a dose of 0.15ml / 10g; the positive control group was administered with propranolol hydrochloride at a dose of 0.03g / kg; Coriander root extract group B, orally administered at a dose of 15g / kg; Coriander root extract group C, administered orally at a dose of 20g / kg; with the prepared medicinal solution, mice in each group were administered intragastrically, every day Once, for 5 consecutive days, the hypoxia experiment used a 150ml Erlenmeyer flask, airtight hypoxia, and observed the survival time of the mice. The results are shown in figure 1 (repeat 5 times).

[0017] The results showed that: Coriander root extract showed obvious anti-hypoxic effect at a dose of ≥10g / kg, and it increased with the increase of the dose...

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Abstract

A preparation method of a common turnip extract relates to the technical field of medicine. The method comprises steps of: 1. weighing dry common turnip, crushing by a crusher, adding 65% ethanol according to a volume ratio of common turnip to ethanol being 1-10, stirring for 1-8 h at 60-100 DEG C, carrying out extraction filtration, discarding residue to obtain a filtrate; and repeating for 3-5 times; 2. carrying out 60% alcohol extraction, drying the residue, adding high water according to a volume ratio of residue to ethanol being 1-10 and boiling; boiling for 1-6 h, carrying out extraction filtration, discarding precipitate to obtain a filtrate; repeating twice; 3. mixing filtrates from 3-5 tomes of 60% alcohol extraction and filtrates from the two times of water extraction, concentrating and drying a filtrate to obtain the common turnip extract. The common turnip extract can enhance anoxia resistance ability of body, promote utility rate of oxygen by body and oxidation and damage resistance of body under a hypoxia condition.

Description

Technical field: [0001] The invention relates to the technical field of medicines, in particular to a preparation method of coriander root extract and its anti-hypoxia application. Background technique: [0002] Oxygen is necessary for the existence of most life forms. Many pathological processes, such as heart disease, severe asthma, carbon monoxide poisoning, suffocation, anesthesia, and poisoning, can cause hypoxia or insufficient oxygen supply in the body. Aerospace, diving, and plateau operations are all prone to hypoxia. Even a short-term partial oxygen deficiency may cause irreversible damage to cells, tissues, and organs, causing some important physiological and pathological changes. How to improve human's ability to tolerate hypoxia and how to effectively intervene the damage of hypoxia to human body is a major problem that we must face and solve. [0003] At present, the commonly used anti-hypoxia method is through acclimation exercise, that is, to fall in a tole...

Claims

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Application Information

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IPC IPC(8): A61K36/83A61P39/06A61P39/00A61K125/00
Inventor 白涛蒋思萍达瓦尼玛马朝
Owner 西藏缘苍工贸有限责任公司
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