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Combination of a source of leucine and a source of omega-3 unsaturated fatty acids for the treatment of hypercalcemia

A technology of unsaturated fatty acid and leucine, applied in the field of combination of leucine source and omega-3 unsaturated fatty acid source for treating hypercalcemia, can solve the problem of not showing specificity and the like

Active Publication Date: 2014-10-29
NV NUTRICIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no experimental results were shown specifically for the treatment of subjects with hypercalcemia

Method used

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  • Combination of a source of leucine and a source of omega-3 unsaturated fatty acids for the treatment of hypercalcemia
  • Combination of a source of leucine and a source of omega-3 unsaturated fatty acids for the treatment of hypercalcemia
  • Combination of a source of leucine and a source of omega-3 unsaturated fatty acids for the treatment of hypercalcemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0099] Example 1: Inhalation formulation example

[0100] Table 1: Nutrient Composition for Suction Feeding

[0101]

Embodiment 2

[0102] Example 2: Tube Feeding Formulation Example

[0103] Table 2: Nutrient Composition for Tube Feeding

[0104]

Embodiment 3

[0105] Embodiment 3 test result

[0106] Materials and methods

[0107] animal

[0108] Male CD2F1 mice (BALB / c x DBA / 2, Harlan / Charles River, Netherlands) aged 6-7 weeks were housed individually in a temperature-controlled room (12:12 light-dark cycle, constant room temperature of 21±1°C) . After one week of acclimatization, the mice were divided into weight-matched groups: (1) a control group receiving a control diet, (2) a tumor-bearing group receiving a control diet, and (3) a tumor-bearing group receiving an experimental diet. The data shown are from the combination of several experimental sessions with the same animal characteristics and experimental procedures (unless otherwise stated) and differ only by the experimental diet employed. All experimental procedures were approved by the Animal Ethics Committee (DEC Committee, Bilthoven, The Netherlands) and followed principles of good laboratory animal care.

[0109] Experimental Diets (Type A and Type B Experiments) ...

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Abstract

The present invention relates to a combination of a leucine source and at least one unsaturated fatty acid source for prophylactic or therapeutic treatment of hypercalcaemia. The invention further relates to a combination of a leucine source and at least one unsaturated fatty acid source for reducing or avoiding a reduction in bone mineral density in a subject or for in vivo regulating of the blood plasma calcium homeostasis.

Description

technical field [0001] The present invention relates to specific combinations of at least two components for use in the treatment of hypercalcaemia, for reducing or avoiding a decrease in bone mineral density in a subject, or for regulating plasma calcium homeostasis in vivo. Background technique [0002] Calcium plays an important role in many different physiological functions, especially the conversion of excitatory stimuli to nerve and muscle tissue. In addition, calcium is involved in signaling pathways that can, for example, lead to changes in hormone balance (eg cholecystokinin balance). In healthy individuals, plasma calcium homeostasis is tightly regulated and maintained within narrow ranges (between 8.4 and 10.2 mg / dL or between 2.1 and 2.6 mM) by parathyroid hormone, vitamin D, and calcitonin (see "Strassman (1993). Mechanisms of paraneoplastic syndromes of colon-26: involvement of interleukin 6 in hypercalcaemia. Cytokine., 5, 463-8"). [0003] Hypercalcemia was...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/198A61K31/202A61P35/00A61P3/14
CPCA61K45/06A61K31/202A23L1/3051A23L1/3008A61K31/198A61K31/715A23L1/305A61K2300/00A23L33/12A23L33/17A23L33/175A61K38/02A61P1/08A61P1/14A61P19/08A61P3/02A61P3/04A61P3/14A61P35/00A61P39/00A61P7/00A23V2002/00A61K31/702
Inventor 克拉斯克·范诺伦霍伊塞·法贝尔阿德里安乌斯·拉姆贝图斯·贝特霍尔德斯·范赫尔福尔特罗伯特·约翰·约瑟夫·哈格曼
Owner NV NUTRICIA