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Raman spectrum accurate quantitative analysis method of powder mixture

A technology of powder mixture and Raman spectroscopy, which is applied in the field of Raman spectroscopy analysis and detection, can solve the problems that the reliability of the results cannot be theoretically guaranteed, and it is difficult to meet the requirements

Inactive Publication Date: 2012-06-13
HUNAN UNIV
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  • Application Information

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Problems solved by technology

These requirements are difficult to meet in practical applications
In addition, except for EMSC, these spectral preprocessing methods are all empirical methods, and they cannot theoretically guarantee the reliability of their results

Method used

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  • Raman spectrum accurate quantitative analysis method of powder mixture
  • Raman spectrum accurate quantitative analysis method of powder mixture
  • Raman spectrum accurate quantitative analysis method of powder mixture

Examples

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Embodiment

[0048] Embodiment: Raman spectroscopy is used for the determination of barium nitrate content in two-component powder mixed samples of barium nitrate and potassium chromate.

[0049]In this example, the Raman spectrum data recorded during the two-component powder mixing process of potassium chromate and barium nitrate is used to test the performance of the present invention for quantitative determination of the powder mixing system when the physical properties of the sample change. First, use a mortar to grind analytically pure potassium chromate and barium nitrate solids into powder, pass through standard sieves of 40, 60, 80, 100, 120, 140, 160, and 200 meshes respectively, and sieve them according to particle size, and divide them into 8 types Powders with different particle sizes (the corresponding average particle sizes are 425, 250, 180, 150, 125, 109, 96 and 75 μm, respectively). Then potassium chromate and barium nitrate powders with the same particle size are 1:0, 0.9...

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Abstract

The invention discloses a Raman spectrum accurate quantitative analysis method of a powder mixture, which includes the following main steps: 1 collecting Raman spectrum data Ica1 of k correction samples, 2 adopting a model to describe the Raman spectral intensity 1k (v) of the kth sample at the position of Raman displacement v and the relationship between mass percents wk and j of J chemical components in the sample, 3 utilizing Ica1 and the content vector wj of the target chemical components of a correction sample set to estimate the multiplier effect vector q of the correction sample set, 4 respectivley establishing a linear correction model between Ica1 and diag (wj) q and between Ica1 and q, and 5 accurately predicting the content of the to-be-detected component from Raman spectrum Itest of an unknown to-be-detected sample by utilizing the established double-correction model. The Raman spectrum accurate quantitative analysis method of the powder mixture resolves the common problem that degree of accuracy of quantitative analysis results of powder samples is poor by the adoption of the Raman spectrum technique and makes it possible to achieve accurate quantitative analysis for a powder mixture system by the adoption of the Raman spectrum technique.

Description

technical field [0001] The invention relates to the field of Raman spectrum analysis and detection in chemical industry, food, pharmacy and other industries, in particular to a method for accurate and quantitative analysis of Raman spectrum of powder mixture. Background technique [0002] Pharmaceutical powder mixing is one of the key links in the quality control of the production process of many pharmaceutical products. Raman spectroscopy has a wide range of applications in the field of pharmaceutical analysis due to its advantages of non-destructive, fast, simple sample preparation (seldom or even no need for sample pretreatment), strong spectral characteristics, and online analysis. prospect. The application of Raman spectroscopy in industrial process analysis and quality control is one of the hotspots studied by spectroscopic process analysis researchers, and is also closely watched by many international pharmaceutical companies. With the development of laser technolog...

Claims

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Application Information

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IPC IPC(8): G01N21/65
Inventor 陈增萍李丽梅金竞文
Owner HUNAN UNIV
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