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Compound fingerprint atlas model used in early-stage gastric cancer diagnosis/early warning, and establishing method thereof

A fingerprint and early gastric cancer technology, which is applied in biological systems, bioinformatics, and special data processing applications, can solve problems such as fingerprint models for diagnosis and early warning of gastric cancer, and achieve the effect of simple operation and abundant resources

Active Publication Date: 2012-06-13
SHANGHAI JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the search, there is no report closely related to the detection of trace volatile organic compounds in the metabolites of gastric cancer cells, and there is no fingerprint model for the diagnosis and early warning of early gastric cancer

Method used

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  • Compound fingerprint atlas model used in early-stage gastric cancer diagnosis/early warning, and establishing method thereof
  • Compound fingerprint atlas model used in early-stage gastric cancer diagnosis/early warning, and establishing method thereof
  • Compound fingerprint atlas model used in early-stage gastric cancer diagnosis/early warning, and establishing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Such as image 3 As shown, take the cells to be tested, detect the concentration of 4-isopropoxybutanol (Peak5), nonanal (peak6) and 4-butoxy n-butanol (peak9) in the volatile metabolites therein, and detect The result is compared with the organic compound fingerprint model of the present invention, 4-isopropoxybutanol [gastric cancer cell] / [normal gastric mucosal cell]≤0.31, nonanal [gastric cancer cell] / [normal gastric mucosal cell] ≤0.36, 4-butoxy n-butanol [gastric cancer cells] / [normal gastric mucosal cells] ≤0.40, can be initially screened for early gastric cancer.

Embodiment 2

[0039] Such as Figure 4 As shown, take the subject’s cells to be tested, detect the volatile metabolites therein, compare the detection results with the organic compound fingerprint model of the present invention, and analyze according to the process shown in the model: 4-isopropyl Oxybutanol[gastric cancer cells] / [normal gastric mucosal cells]≤0.31, nonanal[gastric cancer cells] / [normal gastric mucosal cells]≤0.36, 4-butoxy n-butanol[gastric cancer cells] / [normal gastric Mucosal cells] ≤ 0.40, can be initially screened for early gastric cancer. Further detected the presence of characteristic peaks in volatile organic metabolites: 3-octanone (peak2), 2-butanone (peak8). Then the effect of prompting early gastric cancer can be further strengthened.

[0040] The present invention uses the above-mentioned model to perform early warning of gastric cancer at the cell level in vitro. When the fingerprint model is used in the detection of melanoma cells, lung cancer cells, gastri...

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Abstract

The invention discloses a compound fingerprint atlas model used in early-stage gastric cancer diagnosis / early warning, and an establishing method thereof. According to the invention, the concentration of a trace amount of volatile organic compound in a gastric cancer cell metabolic product is separated and detected by using a gas chromatograph-mass spectrometer, and the atlas model is drawn. A mass volume concentration ratio of 4-isopropoxy butanol to nonanal to 4-butoxyl n-butanol is represented by that: 4-isopropoxy butanol [gastric cancer cell] / [normal gastric mucosa cell] is no higher than 0.31, nonanal [gastric cancer cell] / [normal gastric mucosa cell] is no higher than 0.36, and 4-butoxyl n-butanol [gastric cancer cell] / [normal gastric mucosa cell] is no higher than 0.40. The gastric cancer cell metabolic product has characteristic peaks of 3-octanone and 2-butanone. Volatile organics in a cell metabolic product requiring detection are compared with the fingerprint atlas model provided by the invention, such that the fingerprint atlas model can be used in early-stage gastric cancer diagnosis and early warning.

Description

technical field [0001] The invention relates to a compound fingerprint model and establishment method for early gastric cancer diagnosis / early warning, providing help for early warning of gastric cancer. Background technique [0002] The incidence of gastric cancer ranks second among malignant tumors in my country, and its case fatality rate ranks first. In recent years, the proportion of young patients has been increasing year by year. At present, gastric cancer is mainly detected clinically based on one or more techniques such as X-ray barium meal method, fiber optic endoscopy (including endoscopic ultrasound), histopathological examination, and serum tumor markers. The radiation and medicines taken by the patient during the examination process of the above methods bring certain side effects, and the applicable objects are limited. Moreover, these methods are based on tumor size to diagnose gastric cancer, and the confirmation rate for early or microscopic gastric cancer...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
CPCG01N30/02G06F19/12G01N30/8686G01N33/5091G01N2030/8831G16B5/00
Inventor 张益霞崔大祥
Owner SHANGHAI JIAOTONG UNIV
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