Compound fingerprint atlas model used in early-stage gastric cancer diagnosis/early warning, and establishing method thereof
一种指纹图谱、早期胃癌的技术,应用在生物系统、生物信息学、特殊数据处理应用等方向,能够解决未见胃癌诊断和预警的指纹图谱模型等问题,达到操作简单、资源丰富的效果
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Embodiment 1
[0037] like image 3 As shown, take the cells to be tested, and detect the concentration of 4-isopropoxybutanol (Peak5), nonanal (peak6) and 4-butoxyn-butanol (peak9) in the volatile metabolites, and detect The result is compared with the organic compound fingerprint model of the present invention, 4-isopropoxybutanol [gastric cancer cell] / [normal gastric mucosal cell]≤0.31, nonanal [gastric cancer cell] / [normal gastric mucosal cell] ≤0.36, 4-butoxy n-butanol [gastric cancer cells] / [normal gastric mucosal cells] ≤0.40, can be initially screened for early gastric cancer.
Embodiment 2
[0039] like Figure 4 As shown, take the subject’s cells to be tested, detect the volatile metabolites therein, compare the detection results with the organic compound fingerprint model of the present invention, and analyze according to the process shown in the model: 4-isopropyl Oxybutanol[gastric cancer cells] / [normal gastric mucosal cells]≤0.31, nonanal[gastric cancer cells] / [normal gastric mucosal cells]≤0.36, 4-butoxy n-butanol[gastric cancer cells] / [normal gastric Mucosal cells] ≤ 0.40, can be initially screened for early gastric cancer. It was further detected that there were characteristic peaks in volatile organic metabolites: 3-octanone (peak2), 2-butanone (peak8). Then the effect of prompting early gastric cancer can be further strengthened.
[0040] The present invention uses the above-mentioned model to perform early warning of gastric cancer at the cell level in vitro. The fingerprint model is used in the detection of melanoma cells, lung cancer cells, gastric...
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