Expandable biological adhesive sustained and controlled release preparation for preventing and curing oral diseases and preparation method thereof
A technology of bioadhesive and controlled-release preparations, which is applied in the direction of non-active ingredient medical preparations, drug combinations, and pharmaceutical formulations. Effect of good bioadhesion
Active Publication Date: 2013-11-27
PIVOT PHARMA TECH SHANGHAI
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- Abstract
- Description
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- Application Information
AI Technical Summary
Problems solved by technology
The oral gum preparation method disclosed in the Chinese patent application (patent application number: 91105673.4) is still unsatisfactory in terms of sustained release performance
Method used
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Experimental program
Comparison scheme
Effect test
Embodiment 1-1
[0061]
[0062] Preparation:
[0063] a) mixing the oil phase and the surfactant evenly;
[0064] b) mixing the components of the aqueous phase with the active ingredients, and continuously stirring to ensure that the ingredients are evenly dispersed;
[0065] c) Slowly add the prepared water phase to the oil phase under stirring conditions (200~600rpm), and stir until the end, and then stir at a high speed (above 1000rpm) for 2min to obtain a cream preparation with a viscosity of about 4Pa·S. Just install it.
Embodiment 1-2
[0067]
[0068] The preparation method is the same as that in Example 1-1, and the obtained cream has a viscosity of about 68 Pa·S.
Embodiment 1-3
[0070]
[0071] The preparation method is the same as in Example 1-1, and the obtained cream has a viscosity of about 230 Pa·S.
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The invention discloses an expandable biological adhesive sustained and controlled release preparation for preventing and curing oral diseases, which consists of a water phase, a surfactant and an oil phase. Active ingredients for preventing and curing the oral diseases exist in the water phase and / or the oil phase, wherein the water phase is an inner phase, the oil phase is an outer phase, the boundary of the water phase and the oil phase is constructed and maintained by the surfactant, and the water phase and the oil phase are in a uniform and fully osculatory state. The invention also discloses a preparation method of the biological adhesive sustained and controlled release preparation. Through the preparation, a drug sustained and controlled release mode is formed, a product is lasting and effective, the frequency of usage of the product is reduced, the compliance of the product is increased, and the use cost is reduced; and the release preparation exists at drug administration target positions in a plastic physical form, so that the active ingredients in the product effectively cover the drug administration target positions, even the drug administration target positions with complex physiological structures, such as teeth in an oral cavity and periodontal pocket between gingivae.
Description
technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a bioadhesive sustained-controlled release preparation, in particular to an expandable bioadhesive sustained-controlled release preparation for preventing and treating oral diseases and a preparation method thereof; the present invention can be applied to include but not limited to : Medical devices for topical drug delivery, non-local form of drug delivery, hole filling or tissue repair and surface treatment thereof. Background technique [0002] Emulsions generally consist of two immiscible phases, one of which is uniformly dispersed in the other in the form of fine particles. According to which phase is the dispersed phase (internal phase) or which phase is the continuous phase (external), it can be roughly divided into two basic types: oil-in-water and water-in-oil. The system constructed by the present invention is the latter. At present, when the water-in-oil syst...
Claims
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IPC IPC(8): A61K9/06A61K47/14A61K47/32A61K47/34A61K47/36A61K47/38A61K47/44A61P1/02
Inventor 王建达石宗丰刘岐慕晓军
Owner PIVOT PHARMA TECH SHANGHAI
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