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Medicinal composition for treating or preventing neuropathic pain

A composition and technology of neuropathy, applied in the field of medicine, can solve difficult and laborious problems, and achieve good therapeutic effects, good synergistic effects, and effective therapeutic results

Active Publication Date: 2012-08-29
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Finding effective single agents or combinations with minimal side effects is a difficult and laborious effort, but continues

Method used

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  • Medicinal composition for treating or preventing neuropathic pain
  • Medicinal composition for treating or preventing neuropathic pain
  • Medicinal composition for treating or preventing neuropathic pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-6

[0022] Embodiment 1-6 tablet

[0023] Table 1 Tablet Prescription

[0024]

Embodiment 1

[0025] Example 1 Preparation process: first put pregabalin and cyclodextrin into a mortar, grind and mix evenly, then add carboxymethyl starch sodium, compressible starch and mix evenly, finally add pentoxifylline and mix evenly, use an appropriate amount of 5% PVP absolute ethanol solution is used as a binder to granulate, dried at 40°C, granulated, added with magnesium stearate, mixed evenly, and compressed into tablets.

[0026] Embodiment 2-6 preparation technology is the same as embodiment 1.

Embodiment 7-12

[0027] Embodiment 7-12 tablet

[0028] Table 2 Tablet Prescription

[0029]

[0030]

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PUM

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Abstract

The invention belongs to the field of medicine, and particularly relates to a medicinal composition for treating or preventing neuropathic pain. At present, an effective medicament for treating neuropathic pain is unavailable. The invention provides a medicinal composition for treating neuropathic pain. The medicinal composition contains pregabalin and pentoxifylline, and can further contain diclofenac or a pharmaceutical salt thereof. Compared with separate application of pentoxifylline, pregabalin or diclofenac, the medicinal composition which contains pregabalin and pentoxifylline and further contains diclofenac has a synergistic action on the aspect of treatment of neuropathic pain and a particularly better effect on neuropathic pain caused by diabetes mellitus.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pharmaceutical composition for treating or preventing neuropathic pain. Background technique [0002] Neuropathic pain is a major disease that seriously threatens human life and health, with an incidence rate as high as 1%, especially in diabetic patients as high as 50%. Neuropathic pain refers to the pain caused by damage or lesions of the nervous system, including intractable pain caused by tumor compression, trigeminal neuralgia, herpes zoster neuralgia, pain caused by spinal cord or nerve root compression in patients with spinal diseases, and diabetic patients polyneuritis pain (neuropathic pain caused by diabetes), etc. In contrast to acute pain due to tissue damage, neuropathic pain is often long-term and chronic, lasting days or months. Persistent pain seriously affects people's quality of life. Neuropathic pain has a wide range of clinical causes, diverse symptoms...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/522A61P25/04A61K31/197A61K31/196
Inventor 赵志全张帅
Owner LUNAN PHARMA GROUP CORPORATION