Method for preparing tetracaine
A technology of tetracaine and n-butyraldehyde is applied in the field of preparation of ester anesthetics, can solve the problems of difficult removal, low product purity and high production cost, reduces the time and energy consumption of the process, is conducive to popularization and application, The effect of improving the purity of the crude product
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[0013] One of the preferred specific implementations of the preparation method of the present invention, the specific steps are as follows: 1. 100ml of anhydrous methanol is added to the stirred reaction flask, 13.7g of p-aminobenzoic acid and 8g of n-butyraldehyde are added to the anhydrous methanol, and the temperature rises After reaching 50°C, heat and stir for 4 hours, then concentrate the methanol under reduced pressure to obtain 4-(n-butenylamino)benzoic acid; Add sodium oxide into the high-pressure reactor, then add 1.0g palladium carbon (10%), react under 1.5MPa hydrogen pressure and 90°C temperature, the material stays for 4 hours, release the pressure, and filter with suction, and the filtrate is adjusted to PH=2 with 10% hydrochloric acid , filtered with suction, and the resulting solid was dried at 50°C for 4 hours to obtain 4-(n-butylamino)benzoic acid; ③Add the 4-(n-butylamino)benzoic acid obtained in step ② into another reaction flask, Add 100ml of toluene as a...
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