Systems and methods for producing hyperpolarized materials and mixtures thereof
A technology of hyperpolarization and mixing device, which can be used in preparations for in vivo experiments, pharmaceutical formulations, MRI/MRI contrast agents, etc., and can solve problems such as difficulty in material handling
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example 1
[0097] It was frozen into high surface area pellets by introducing deuterated acetic acid into LN2 in finely divided form as droplets. The surface area of the pellets was measured by BET to be about 5m 2 / g. The pellet was placed in the sample chamber of a dilution freezer and cooled to T 3 He is added to the sample chamber to accelerate magnetic relaxation. After polarizing the sample (which can be monitored using NMR), the 4 He is added to the sample chamber to be removed from the sample surface 3 He. The sample is heated to T approximately equal to 5K and the helium is removed. The pellets were removed from the chamber of the polarizing cryostat while maintained at a temperature of T<10K and in a magnetic field greater than 0.1 Tesla. The pellet was transferred to a transport cryostat where similar field / temperature conditions were maintained. After transport, the temperature of the pellet is rapidly raised from T < 10K to T about 77K by, for example, immersing the ...
example 2
[0137] By making liquid 1- 13 C-labeled acetic acid was frozen into pellets by dropping them into liquid nitrogen ("LN2"). The pellet is harvested and introduced into a high B / T environment (such as a low temperature environment at about 150 mK in a background field of 8-10 Tesla). Keep it in a high B / T environment until the methyl group in acetic acid ("CH 3 ”) has fully relaxed, this can be done using NMR or by pre-measurement of the proton T under the conditions described 1 Come and observe. The pellets are then directed / expelled from the high B / T environment through a catheter using high pressure helium. It will be appreciated that the practice of accelerating photofrozen pellets is generally known, for example, in the art of introducing frozen hydrogen pellets into a fusion tokamak at a velocity of about 1000 m / sec. As the agglomerate is expelled, it is transported out of the polarization field and into the very low field region, whereby the polarization flows from th...
example 3
[0139] Liquid 1- 13 C Acetic acid pellets and cooled to high B / T conditions. When CH 3 When the protons in the group are already polarized, the pellet is heated above T min But still well below its melting temperature (Tmelting of acetic acid is about 17°C), while still in the polarizing field. It can then be directed / expelled from the polarizing cryostat, whereupon it can be collected for storage / transportation or melted for immediate use.
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