Croton processing method for treatment of tuberculosis

Abstract

The present invention relates to a croton processing method for treatment of tuberculosis, and specific relates to a high temperature processing attenuation method of a traditional Chinese medicine croton and the role thereof in the treatment of tuberculosis. The croton processed product is obtained through three methods of high-temperature stir-frying, high temperature baking, and microwave heating. The processed croton has no toxic protein detected. LD50 increases significantly. The relative content of each component in the croton is essentially unchanged, and the croton oil content is relatively elevated. The processed croton is mixed with other traditional Chinese medicines to make pills which have significant role in resisting mycobacterium tuberculosis in vitro and in vivo. The croton processing method for treatment of tuberculosis disclosed by the invention has effects of reducing toxicity and enhancing efficacy, and has very prominent advantages compared with conventional croton processing methods such as baking, boiling, steaming, etc.

Description

technical field [0001] The invention relates to a processing method of Chinese medicinal materials, in particular to a processing method of croton for treating tuberculosis. Background technique [0002] Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis infection. Mycobacterium tuberculosis invades the lungs and causes tuberculosis, which has been an infectious disease since ancient times and has become the number one infectious disease in the world in recent years. According to the report of the World Health Organization, nearly 1 / 3 of the people in the world have been infected with Mycobacterium tuberculosis, that is, 2 billion people have been infected with Mycobacterium tuberculosis, and about 3 million people die of tuberculosis every year. Tuberculosis has become one of the leading causes of death from infectious diseases in adults worldwide. my country is one of the 22 countries with a high burden of tuberculosis in the world, and the...

AI Technical Summary

Problems solved by technology

The above-mentioned Bawa pills are prepared by the traditional wax method, which is cumbersome and complicated for modern applications, and the controllability is poor, and the safety of medication cannot be guaranteed.

The 2010 edition of "Chinese Pharmacopoeia" adopts two methods of making croton cream. The croton oil removed by the pressing method is the active ingredient, which is a waste of resources. The pressing method uses slight heat, and the dilution method does not have a heating process, so the croton toxin cannot be removed. Toxicity will increase the risk of clinical safety medication

In the patent application number 200410038035.0, the croton is fried with beeswax until the kernels are burnt yellow, and then 60-80% ethanol is used to extract the croton kernels. This method cannot fully extract the active ingredient croton oil, resulting in a large proportion of croton in the formulation. The use of croton in the patent will cause a waste of medicinal resources

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