Preparation process and production method for Magnolia Officinalis Seven-Ingredient Decoction preparation in an integrated new dosage form

A production method and new dosage form technology, applied in the field of preparation of new integrated dosage forms of Houpu Qiwu Decoction, to achieve the effect of wide target distribution and strong slow and controlled release performance

Inactive Publication Date: 2013-01-02
SUZHOU ZHIWEITANG BIOLOGICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The domestic and foreign databases were used to search for novelties, and the following conclusions were drawn based on the reading, analysis and comparison of domestic and foreign literature: the innovation of the project of "developing new integrated dosage forms of nano-drugs with combined technology": 1) the use of nano-scale traditional Chinese medicine rich in trace elements Nanospheres, nanocapsules, polymer micelles, and solid ester nanoparticles of different particle sizes are prepared with different drug carriers such as powder, drug monomer, effective part, effective part group, traditional Chinese medicine extract, decoction concentrate, etc. , magnetic nanoparticles, immune nanoparticles, nanoemulsions, suspensions, vesicles, drug plasmids, microcapsules, nanoparticles, nanospheres, nanocapsules, etc., and then mix them and put them into soft and hard capsules at the same time Combined use and preparation of an integrated new dosage form or other types of integrated new dosage forms according to the above method; 2) Research and development of "nano-drug integrated new dosage form" by using nano-carrier combination technology and the theory of integrated traditional Chinese and Western medicine. The product has target It has the characteristics of wide distribution and strong slow and controlled release performance; there is no public report in the domestic literature, and the comprehensive technical characteristics of this project have certain novelty and innovation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The following raw materials are prepared according to the aforementioned method: extract, nanoparticle, microcapsule and nanoparticle.

[0046] The raw materials for making active ingredients are as follows: 24 parts of magnolia officinalis, 9 parts of licorice, 9 parts of rhubarb, 10 parts of jujube, 5 parts of citrus aurantium, 6 parts of cassia twig and 15 parts of ginger.

[0047] The manufacturing process is as follows: in a GMP10000 class clean room, the extract, nanoparticles, microcapsules, and nanoparticles are mixed in a ratio of 4:2:2:2, and part of the hard capsules are used in the first part of the "Chinese Pharmacopoeia" of the 2010 edition. Standard, no auxiliary materials and preservatives are added, and hard capsules are filled with automatic capsule filling machines to make hard capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally, according to the production batch u...

Embodiment 2

[0049]The following raw materials are prepared according to the aforementioned method: water decoction concentrate, nanoliposome, nanoemulsion, and microemulsion.

[0050] The raw materials for making active ingredients are as follows: 24 parts of magnolia officinalis, 9 parts of licorice, 9 parts of rhubarb, 10 parts of jujube, 5 parts of citrus aurantium, 6 parts of cassia twig and 15 parts of ginger.

[0051] The manufacturing process is as follows: in a GMP10000 class clean room, the decoction concentrate, nanoliposome, nanoemulsion, and microemulsion are mixed according to the ratio of 4:2:2:2, and a preparation of the 2010 edition of "Chinese Pharmacopoeia" is used. Part of the soft capsule standard, without adding auxiliary materials and preservatives, adopts a fully automatic soft capsule filling machine to sub-pack soft capsules to make soft capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packin...

Embodiment 3

[0053] The following raw materials are prepared according to the aforementioned method: extract, nanoparticle, and nanoemulsion.

[0054] The raw materials for making active ingredients are as follows: 24 parts of magnolia officinalis, 9 parts of licorice, 9 parts of rhubarb, 10 parts of jujube, 5 parts of citrus aurantium, 6 parts of cassia twig and 15 parts of ginger.

[0055] The manufacturing process is as follows: After mixing the extract, nanoparticles, and nanoemulsions in a 4:3:3 ratio in a GMP10000 clean room, the 2010 edition of the "Chinese Pharmacopoeia" Part I of the film preparation standard is used, and the film-forming material is made of Polyvinyl alcohol, made into film. Cartoning, sealing, sticking labels, printing codes, packing and other internal and external packaging. Finally, according to the production batch uniform instant sterilization, and issue a sterilization report. The size of each film is 2-40 square centimeters, and each film is applied for ...

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Abstract

The invention relates to preparation process and production method for a Magnolia Officinalis Seven-Ingredient Decoction preparation in an integrated new dosage form, comprising raw materials of effective component including (by weight parts) Magnolia officinalis 24, Radix Glycyrrhizae 9, Radix Et Rhizoma Rhei 9, Ziziphus jujuba (Fructus Jujubae) 10, Fructus Aurantii Immaturus (Citrus aurantium and / or Citrus sinensis) 5, Cinnamomum cassia twig 6, and Zingiber officinale 15. The production method includes: supersonic air flow comminution, alcohol / water extraction, ultrasonic pulverization and extraction, water decoction and concentration, supersonic spray-drying, nanometer grinding, high-pressure homogenization, and nanoparticle preparation. The invention utilizes the advantages such as multi-cooperation and multi-target of the nano-carrier coupling technique. The invention can greatly reduce production cost and greatly increase product quality after large-scale production, and enhance the targeting effect and slow-controlled release effect of drug. The preparation can be administered orally and externally in four periods of time according to midnight-noon ebb-flow and human qi and blood flow rule. The preparation may also be prepared into pellicle and transdermal agent, which can be attached to different parts of human body according to midnight-noon ebb-flow and human qi and blood flow rule or be directly absorbed transdermally.

Description

technical field [0001] The invention relates to a preparation technology of a new integrated dosage form of Houpu Qiwu Decoction, and also relates to a preparation technology of a new integrated dosage form of Houpu Qiwu Decoction and a production method thereof. Background technique [0002] Due to too many chemical components, the chemical reaction of compound decoction of traditional Chinese medicine has not yet been revealed its mysterious veil, but some mysterious black boxes of medicinal effects in traditional Chinese medicine prescriptions are hidden in the decoction of traditional Chinese medicine. Traditional Chinese medicine is modernized and only uses monomers and effective parts. Chinese herbal decoction concentrate cannot be discarded! When the traditional Chinese medicine prescription is decocted in water, due to the high temperature when the prescription is decocted together and the complex chemical environment in the solution, complexation, hydrolysis, oxida...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/00A61P1/00A61P1/04A61P1/10A61P9/06A61P9/10A61P9/14A61P17/00
Inventor 杨洪舒
Owner SUZHOU ZHIWEITANG BIOLOGICAL TECH
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