Application of jatrorrhizine for treating candida albicans infectious diseases

A technology for Candida albicans and infectious diseases, applied in the field of application of jatrorrhizine in treating Candida albicans infectious diseases, capable of solving skin candidiasis, mucosal candidiasis, visceral or central nervous system candidiasis and mucosal candidiasis Pneumonia, gastroenteritis, endocarditis, meningitis, encephalitis, drug resistance, and high recurrence rate caused by the spread of germs on the skin and other places

Inactive Publication Date: 2013-01-09
XIAN YUYE PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The main problems in the treatment of Candida albicans infection are: (1) there is still a lack of specific drugs; (2) the comprehensive treatment procedure is complicated and the treatment cycle is long; (3) most of the currently used therapeutic drugs are resistant to There are toxic side effects such as digestive system; (4) The disease recurrence rate is high, and there are few optional therapeutic drugs
(4) Reversal of multidrug resistance
However, research on the pharmacological effects of jatrorrhizine against Candi...

Method used

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  • Application of jatrorrhizine for treating candida albicans infectious diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: Effect of jatrorrhizine on the growth of Candida albicans in vitro

[0019] 1. Purpose of the experiment To study the killing effect of jatrorrhizine on Candida albicans, and provide experimental basis for the clinical application of jatrorrhizine.

[0020] 2Materials and methods are mainly carried out according to the method of Zhang Qifeng et al. .

[0021] 1.1 Materials

[0022] 1.1.1 The experimental reagent jatrorrhizine is prepared by our company, the purity is 98.8%, the batch number is 20110922; the concentration of the test drug is 500mg / L, and the preparation method is: accurately weigh jatrorrhizine and dissolve it in normal saline. The contrast reagent is iodophor (purchased from Dezhou Ruitai Washing and Disinfection Products Co., Ltd.), and the preparation concentration is 0.5%; the positive control reagent is cephalosporin (purchased from Guilin Dahua Pharmaceutical Co., Ltd.), using normal saline as solvent Prepare a solution, and store ...

Embodiment 2

[0037] Example 2: Effect of jatrorrhizine on macrophage function in immunosuppressed mice infected with Candida albicans

[0038] 1. Purpose of the experiment To study the effect of jatrorrhizine on the function of macrophages in immunosuppressed mice infected with Candida albicans, and to provide experimental basis for the clinical application of jatrorrhizine.

[0039] 2Materials and methods are mainly based on the method of Hu Guowei et al. (Hu Guowei, Dong Qun. Effect of jatrorrhizine on macrophage function in immunosuppressed mice infected with Candida albicans. Chinese Clinical Pharmacology and Therapeutics, 2011, 16(3): 270-273) implementation.

[0040] 1.1 Materials

[0041] 1.1.1 The experimental reagent jatrorrhizine is prepared by our company, the purity is 98.8%, the batch number is 20110922; the concentration of the test drug is 500mg / L, and the preparation method is: accurately weigh jatrorrhizine and dissolve it in normal saline. Cyclophosphamide was purchased...

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Abstract

The invention discloses a novel application of jatrorrhizine for treating candida albicans infectious diseases. The jatrorrhizine can be extracted from plants of coptis roots, amur corktree barks, caulis mahoniae and the like. The study shows that half bacteriostasis concentration of the jatrorrhizine to candida albicans is 139+/-21mg/L, and effective dose of the jatrorrhizine for enhancing body resistibility of a low immune function mouse to the candida albicans is 30mg/Kg. The jatrorrhizine and pharmaceutically acceptable salts, esters or sugars, excipients and the like are utilized for preparing medicines for treating diseases caused by the fact that the candida albicans infect human and livestock, and the jatrorrhizine can be applied to, but is not limited to, medicines for treating human skins, mucous membranes, internal organs or nervous centralis candidiasis, livestock upper digestive tract mycoses and the like. The jatrorrhizine and the pharmaceutically acceptable salts, esters or sugars and excipients and the like can be prepared to be injection, oral administration and external preparations and dosage forms thereof which are pharmaceutically acceptable such as injections, tablets, capsules, liniments, pastes, smearing agents, emulsions, nanoparticle emulsions, and the like.

Description

Technical field [0001] The present invention relates to a new application of jatrorrhizine, in particular to the application of jatrorrhizine in the preparation of medicines for the prevention and treatment of Candida albicans infectious diseases in humans, livestock and poultry, especially human skin candidiasis and mucous membranes caused by Candida albicans infection. Candidiasis, visceral or central nervous candidiasis, pneumonia, gastroenteritis, endocarditis, meningitis, encephalitis and other diseases caused by the spread of pathogens on the mucous membranes and skin, and fungal diseases of the upper gastrointestinal tract of livestock and poultry. Background technique [0002] Candida albicans (Monilia albican or canidia Albicans) is a fungus that usually exists in the oral cavity, upper respiratory tract, intestinal tract and vagina of normal people and livestock such as chickens and ducks. It generally has a small number in normal organisms and does not cause diseas...

Claims

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Application Information

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IPC IPC(8): A61K31/4375A61P31/10
Inventor 王靓叶玉茜乐凤鸣
Owner XIAN YUYE PHARMA TECH CO LTD
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