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Application of Houttuynoid A in antibacterial medicine

An anti-bacterial and drug technology, applied in the direction of anti-bacterial drugs, resistance to vector-borne diseases, pharmaceutical formulations, etc., can solve the problems of digestive tract irritation, strong accumulation of toxicity, etc.

Active Publication Date: 2013-06-19
海门市知舟工业设计有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The spread of pathogenic bacteria and the enhancement of drug resistance seriously threaten human health and life. Antibacterial drugs have been widely used as routine drugs in the treatment of AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) Treatment, although antibacterial agents currently used clinically (such as ketoconazole, amikacin, gentamicin, vigorconazole, itraconazole, terbinafine, amphotericin, fluconazole, etc.) The curative effect on skin and superficial infection is good, but these antibacterial drugs have strong cumulative toxicity, often causing liver and kidney damage, gastrointestinal irritation, dizziness, allergies, etc. one of the hotspots

Method used

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  • Application of Houttuynoid A in antibacterial medicine
  • Application of Houttuynoid A in antibacterial medicine
  • Application of Houttuynoid A in antibacterial medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: the preparation of compound Houttuynoid A tablet involved in the present invention:

[0013] Get 20 grams of compound Houttuynoid A, add 180 grams of conventional adjuvants for preparing tablets, mix well, and make 1000 tablets on a conventional tablet press.

Embodiment 2

[0014] Embodiment 2: the preparation of compound Houttuynoid A capsule involved in the present invention:

[0015] Get 20 grams of compound Houttuynoid A, add conventional auxiliary materials such as starch 180 grams for preparing capsules, mix well, and pack into capsules to make 1000 tablets.

[0016] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example

[0017] Experimental example: Antibacterial activity of Houttuynoid A

[0018] The antimicrobial activity test adopts the method of concentration dilution, and each measurement is repeated three times. The test pathogens include Escherichia coli, Pseudomonas fluorescens, Staphylococcus aureus, Proteus, and Cryptococcus neoformans, and the concentration of the bacterial solution is 10 5 individual / mL. The initial concentration of Houttuynoid A was 50.0 μg / mL (5% dimethyl sulfoxide DMSO), and it was serially diluted to 0.098 μg / mL. The same volume of bacterial liquid and test samples were mixed and cultured in a 96-well plate, and the bacterial culture temperatures were respectively 37°C, observe after 24 hours of incubation time, if no colonies are found, it is the lowest antibacterial concentration of the sample, that is, the MIC value. The positive control of this experiment was amikacin sulfate, and the antibacterial results of Houttuynoid A are shown in Table 1.

[0019] T...

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PUM

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Abstract

The invention relates to application of Houttuynoid A in preparation of an antibacterial medicine, belonging to the technical field of new application of medicine. Houttuynoid A has very strong effect on inhibiting escherichia coli, pseudomonas fluorescens, staphylococcus aureus, proteusbacillus vulgaris, cryptococcus neoformans, so that Houttuynoid A can be taken as the antibacterial medicine and is expected to be applied in the preparation of the relative medicines. The application of Houttuynoid A in preparation of the antibacterial medicineis disclosed firstly. The skeleton type belongs to new skeleton type, and the bacteriostasis activity of Houttuynoid A is unexpectedly strong; and the probability that other compounds provide any revelation does not exist, Houttuynoid A has the excellent substantive features, and Houttuynoid A obviously has a remarkable progress when being used for preventing and treating bacterial infection.

Description

technical field [0001] The present invention relates to the use of Houttuynoid A, in particular to the application of Houttuynoid A in the preparation of antibacterial drugs. Background technique [0002] The spread of pathogenic bacteria and the enhancement of drug resistance seriously threaten human health and life. Antibacterial drugs have been widely used as routine drugs in the treatment of AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) Treatment, although antibacterial agents currently used clinically (such as ketoconazole, amikacin, gentamicin, vigorconazole, itraconazole, terbinafine, amphotericin, fluconazole, etc.) The curative effect on skin and superficial infection is good, but these antibacterial drugs have strong accumulation toxicity, often causing liver and kidney damage, gastrointestinal irritation, dizziness, allergies, etc. one of the hotspots. [0003] The compound Houttuynoid A involved in the present...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P31/04
CPCY02A50/30
Inventor 蒋鹤松黄晨吴俊华
Owner 海门市知舟工业设计有限公司